<abstract xmlns="http://www.w3.org/1999/xhtml"><p> New photosensitizers are needed for photodynamic antimicrobial and anticancer chemotherapy. Two new groups of proflavine derivatives have been recently prepared and their action on the cancer cells has been investigated by our research team. In this paper, we studied an effect of UV-A irradiation of two groups of proflavines: 3,6-bis((1-alkyl-5-oxo-imidazolidin-2-yliden)imino)acridine hydrochlorides (AcrDIMs) and 1’,1”-(acridin-3,6-diyl)-3’,3”-dialkyldithiourea hydrochlorides (AcrDTUs) on a plasmid DNA (pDNA). These compounds induced a photocleavage of pDNA characteristic by generation of free radicals, single strand DNA breaks and formation of an open circular form of pDNA.</p></abstract>

New photosensitizers are needed for photodynamic antimicrobial and anticancer chemotherapy. Two new groups of proflavine derivatives have been recently prepared and their action on the cancer cells has been investigated by our research team. In this paper, we studied an effect of UV-A irradiation of two groups of proflavines: 3,6-bis((1-alkyl-5-oxo-imidazolidin-2-yliden)imino)acridine hydrochlorides (AcrDIMs) and 1’,1”-(acridin-3,6-diyl)-3’,3”-dialkyldithiourea hydrochlorides (AcrDTUs) on a plasmid DNA (pDNA). These compounds induced a photocleavage of pDNA characteristic by generation of free radicals, single strand DNA breaks and formation of an open circular form of pDNA.

Photocleavage of pDNA by bis-imidazolidino and bis-thioureido proflavines

Department of Biochemistry and Microbiology, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, Radlinského 9, 812 37 Bratislava, Slovak Republic

Department of Organic Chemistry, Pavol Jozef Šafárik University, Moyzesova 11, 041 57 Košice, Slovak Republic

Acta Chimica Slovaca

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Photocleavage of pDNA by bis-imidazolidino and bis-thioureido proflavines"}

New photosensitizers are needed for photodynamic antimicrobial and anticancer chemotherapy. Two new groups of proflavine derivatives have been recently...

Photocleavage of pDNA by bis-imidazolidino and bis-thioureido proflavines

Online veröffentlicht: 05. Dez. 2015

Seitenbereich: 97 - 100

DOI: https://doi.org/10.1515/acs-2015-0017

Schlüsselwörter
photocleavage of DNA, photodynamic therapy, proflavine derivatives

© Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Photocleavage of pDNA by bis-imidazolidino and bis-thioureido proflavines

Online veröffentlicht: 05. Dez. 2015

Seitenbereich: 97 - 100

DOI: https://doi.org/10.1515/acs-2015-0017

Schlüsselwörterphotocleavage of DNA, photodynamic therapy, proflavine derivatives

© Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Schlüsselwörter
photocleavage of DNA, photodynamic therapy, proflavine derivatives