This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002; 420:860–7.CoussensLMWerbZInflammation and cancer2002420860710.1038/nature01322Search in Google Scholar
Oeckinghaus A, Ghosh S. The NF-κB family of transcription factors and its regulation. Cold Spring Harb Perspect Biol. 2009; 1:a000034. doi: 10.1101/cshperspect.a000034OeckinghausAGhoshSThe NF-κB family of transcription factors and its regulation20091a00003410.1101/cshperspect.a000034Open DOISearch in Google Scholar
Héron E, Deloukas P, van Loon APGM. The complete exon-intron structure of the 156-kb human gene NFKB1, which encodes the p105 and p50 proteins of transcription factors NF-κB and IκB-γ: implications for NF-κB-mediated signal transduction. Genomics. 1995; 30:493–505.HéronEDeloukasPvan LoonAPGMThe complete exon-intron structure of the 156-kb human gene NFKB1, which encodes the p105 and p50 proteins of transcription factors NF-κB and IκB-γ: implications for NF-κB-mediated signal transduction19953049350510.1006/geno.1995.1270Search in Google Scholar
Le Beau MM, Ito C, Cogswell P, Espinosa R 3rd, Fernald AA, Baldwin AS Jr. Chromosomal localization of the genes encoding the p50/p105 subunits of NF-κB (NFKB2) and the IκB/MAD-3 (NFKBI) inhibitor of NF-κB to 4q24 and 14q13, respectively. Genomics. 1992; 14:529–31.Le BeauMMItoCCogswellPEspinosaR3rdFernaldAABaldwinASJrChromosomal localization of the genes encoding the p50/p105 subunits of NF-κB (NFKB2) and the IκB/MAD-3 (NFKBI) inhibitor of NF-κB to 4q24 and 14q13, respectively1992145293110.1016/S0888-7543(05)80261-7Search in Google Scholar
Karban AS, Okazaki T, Panhuysen CI, Gallegos T, Potter JJ, Bailey-Wilson JE, et al. Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis. Hum Mol Genet. 2004; 13:35–45.KarbanASOkazakiTPanhuysenCIGallegosTPotterJJBailey-WilsonJEFunctional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis200413354510.1093/hmg/ddh00814613970Search in Google Scholar
Zhou Y, Eppenberger-Castori S, Marx C, Yau C, Scott GK, Eppenberger U, Benz CC. Activation of nuclear factor-κB (NFκB) identifies a high-risk subset of hormone-dependent breast cancers. Int J Biochem Cell Biol. 2005; 37:1130–44.ZhouYEppenberger-CastoriSMarxCYauCScottGKEppenbergerUBenzCCActivation of nuclear factor-κB (NFκB) identifies a high-risk subset of hormone-dependent breast cancers20053711304410.1016/j.biocel.2004.09.00615743683Search in Google Scholar
Li R-N, Hung Y-H, Lin C-H, Chen Y-H, Yen J-H. Inhibitor IκBα promoter functional polymorphisms in patients with rheumatoid arthritis. J Clin Immunol. 2010; 30:676–80.LiR-NHungY-HLinC-HChenY-HYenJ-HInhibitor IκBα promoter functional polymorphisms in patients with rheumatoid arthritis2010306768010.1007/s10875-010-9439-920563630Search in Google Scholar
Chen F, Castranova V, Shi X, Demers LM. New insights into the role of nuclear factor-κB, a ubiquitous transcription factor in the initiation of diseases. Clin Chem. 1999; 45:7–17.ChenFCastranovaVShiXDemersLMNew insights into the role of nuclear factor-κB, a ubiquitous transcription factor in the initiation of diseases19994571710.1093/clinchem/45.1.7Search in Google Scholar
Dong QG, Sclabas GM, Fujioka S, Schmidt C, Peng B, Wu T, et al. The function of multiple IκB: NF-κB complexes in the resistance of cancer cells to Taxol-induced apoptosis. Oncogene. 2002; 21:6510–19.DongQGSclabasGMFujiokaSSchmidtCPengBWuTThe function of multiple IκB: NF-κB complexes in the resistance of cancer cells to Taxol-induced apoptosis20022165101910.1038/sj.onc.120584812226754Search in Google Scholar
Hayden MS, Ghosh S. Shared principles in NF-κB signaling. Cell. 2008; 132:344–62.HaydenMSGhoshSShared principles in NF-κB signaling20081323446210.1016/j.cell.2008.01.02018267068Search in Google Scholar
Karin M. NF-κB as a critical link between inflammation and cancer. Cold Spring Harb Perspect Biol. 2009; 1:a000141. doi: 10.1101/cshperspect.a000141KarinMNF-κB as a critical link between inflammation and cancer20091a00014110.1101/cshperspect.a000141277364920066113Open DOISearch in Google Scholar
Madrid LV, Mayo MW, Reuther JY, Baldwin AS Jr. Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-κB through utilization of the IκB kinase and activation of the mitogen-activated protein kinase p38. J Biol Chem. 2001; 276:18934–40.MadridLVMayoMWReutherJYBaldwinASJrAkt stimulates the transactivation potential of the RelA/p65 Subunit of NF-κB through utilization of the IκB kinase and activation of the mitogen-activated protein kinase p382001276189344010.1074/jbc.M10110320011259436Search in Google Scholar
Gupta SC, Sundaram C, Reuter S, Aggarwal BB. Inhibiting NF-κB activation by small molecules as a therapeutic strategy. Biochim Biophys Acta. 2010; 1799:775–87.GuptaSCSundaramCReuterSAggarwalBBInhibiting NF-κB activation by small molecules as a therapeutic strategy201017997758710.1016/j.bbagrm.2010.05.004295598720493977Search in Google Scholar
Saggu R, Schumacher T, Gerich F, Rakers C, Tai K, Delekate A, Petzold GC. Astroglial NF-kB contributes to white matter damage and cognitive impairment in a mouse model of vascular dementia. Acta Neuropathol Commun. 2016; 4:76. doi: 10.1186/s40478-016-0350-3SagguRSchumacherTGerichFRakersCTaiKDelekateAPetzoldGCAstroglial NF-kB contributes to white matter damage and cognitive impairment in a mouse model of vascular dementia201647610.1186/s40478-016-0350-3497306127487766Open DOISearch in Google Scholar
Best KT, Lee FK, Knapp E, Awad HA, Loiselle AE. Deletion of NFKB1 enhances canonical NF-κB signaling and increases macrophage and myofibroblast content during tendon healing. Sci Rep. 2019; 9:10926. doi: 10.1038/s41598-019-47461-5BestKTLeeFKKnappEAwadHALoiselleAEDeletion of NFKB1 enhances canonical NF-κB signaling and increases macrophage and myofibroblast content during tendon healing201991092610.1038/s41598-019-47461-5666278931358843Open DOISearch in Google Scholar
Stone S, Jamison S, Yue Y, Durose W, Schmidt-Ullrich R, Lin W. NF-κB activation protects oligodendrocytes against inflammation. J Neurosci. 2017; 20;37:9332–44.StoneSJamisonSYueYDuroseWSchmidt-UllrichRLinWNF-κB activation protects oligodendrocytes against inflammation2017203793324410.1523/JNEUROSCI.1608-17.2017560747228842413Search in Google Scholar
Gareus R, Kotsaki E, Xanthoulea S, van der Made I, Gijbels MJ, Kardakaris R, et al. Endothelial cell-specific NF-κB inhibition protects mice from atherosclerosis. Cell Metab. 2008; 8:372–83.GareusRKotsakiEXanthouleaSvan der MadeIGijbelsMJKardakarisREndothelial cell-specific NF-κB inhibition protects mice from atherosclerosis200883728310.1016/j.cmet.2008.08.01619046569Search in Google Scholar
Fontaine-Bisson B, Wolever TM, Connelly PW, Corey PN, El-Sohemy A. NF-κB–94Ins/Del ATTG polymorphism modifies the association between dietary polyunsaturated fatty acids and HDL-cholesterol in two distinct populations. Atherosclerosis. 2009; 204:465–70.Fontaine-BissonBWoleverTMConnellyPWCoreyPNEl-SohemyANF-κB–94Ins/Del ATTG polymorphism modifies the association between dietary polyunsaturated fatty acids and HDL-cholesterol in two distinct populations20092044657010.1016/j.atherosclerosis.2008.10.03719070859Search in Google Scholar
Özbilüm N, Arslan S, Berkan Ö, Yanartaş M, Aydemir EI. The role of NF-κB1A promoter polymorphisms on coronary artery disease risk. Basic Clin Pharmacol Toxicol. 2013; 113:187–92.ÖzbilümNArslanSBerkanÖYanartaşMAydemirEIThe role of NF-κB1A promoter polymorphisms on coronary artery disease risk20131131879210.1111/bcpt.1208523692311Search in Google Scholar
Oner T, Arslan C, Yenmis G, Arapi B, Tel C, Aydemir B, Sultuybek GK. Association of NFKB1A and microRNAs variations and the susceptibility to atherosclerosis. J Genet. 2017; 96:251–9.OnerTArslanCYenmisGArapiBTelCAydemirBSultuybekGKAssociation of NFKB1A and microRNAs variations and the susceptibility to atherosclerosis201796251910.1007/s12041-017-0768-928674224Search in Google Scholar
Lai H-M, Li X-M, Yang Y-N, Ma Y-T, Xu R, Pan S, et al. Genetic variation in NFKB1 and NFKBIA and susceptibility to coronary artery disease in a Chinese Uygur population. PLoS One. 2015; 10:e0129144. doi: 10.1371/journal.pone.0129144LaiH-MLiX-MYangY-NMaY-TXuRPanSGenetic variation in NFKB1 and NFKBIA and susceptibility to coronary artery disease in a Chinese Uygur population201510e012914410.1371/journal.pone.0129144Open DOISearch in Google Scholar
Seidi A, Mirzaahmadi S, Mahmoodi K, Soleiman-Soltanpour M. The association between NFKB1 -94ATTG ins/del and NFKB1A 826C/T genetic variations and coronary artery disease risk. Mol Biol Res Commun. 2018; 7:17–24.SeidiAMirzaahmadiSMahmoodiKSoleiman-SoltanpourMThe association between NFKB1 -94ATTG ins/del and NFKB1A 826C/T genetic variations and coronary artery disease risk201871724Search in Google Scholar
Vogel U, Jensen MK, Due KM, Rimm EB, Wallin H, Nielsen MR, et al. The NFKB1 ATTG ins/del polymorphism and risk of coronary heart disease in three independent populations. Atherosclerosis. 2011; 219:200–4.VogelUJensenMKDueKMRimmEBWallinHNielsenMRThe NFKB1 ATTG ins/del polymorphism and risk of coronary heart disease in three independent populations2011219200410.1016/j.atherosclerosis.2011.06.018Search in Google Scholar
Kim SK, Jang HM, Kim D-Y. The promoter polymorphism of NFKB1 gene contributes to susceptibility of ischemic stroke in Korean population. J Exerc Rehabil. 2018;14:1096–1100.KimSKJangHMKimD-YThe promoter polymorphism of NFKB1 gene contributes to susceptibility of ischemic stroke in Korean population2018141096110010.12965/jer.1836592.296Search in Google Scholar
Jin S-Y, Luo J-Y, Li X-M, Liu F, Ma Y-T, Gao X-M, Yang Y-N. NFKB1 gene rs28362491 polymorphism is associated with the susceptibility of acute coronary syndrome. Biosci Rep. 2019; 39:BSR20182292. doi: 10.1042/BSR20182292JinS-YLuoJ-YLiX-MLiuFMaY-TGaoX-MYangY-NNFKB1 gene rs28362491 polymorphism is associated with the susceptibility of acute coronary syndrome201939BSR20182292.10.1042/BSR20182292Open DOISearch in Google Scholar
Peterson JM, Wang DJ, Shettigar V, Roof SR, Canan BD, Bakkar N, et al. NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model. Nat Commun. 2018; 9:3431. doi: 10.1038/s41467-018-05910-1.PetersonJMWangDJShettigarVRoofSRCananBDBakkarNNF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model20189343110.1038/s41467-018-05910-1Open DOISearch in Google Scholar
Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004; 116:281–97.BartelDPMicroRNAs: genomics, biogenesis, mechanism, and function20041162819710.1016/S0092-8674(04)00045-5Search in Google Scholar
Chen Y, Fu LL, Wen X, Liu B, Huang J, Wang JH, et al. Oncogenic and tumor suppressive roles of microRNAs in apoptosis and autophagy. Apoptosis. 2014; 19:1177–89.ChenYFuLLWenXLiuBHuangJWangJHOncogenic and tumor suppressive roles of microRNAs in apoptosis and autophagy20141911778910.1007/s10495-014-0999-724850099Search in Google Scholar
O’Neill LA, Sheedy FJ, McCoy CE. MicroRNAs: the fine-tuners of Toll-like receptor signalling. Nat Rev Immunol. 2011; 11:163–75.O’NeillLASheedyFJMcCoyCEMicroRNAs: the fine-tuners of Toll-like receptor signalling2011111637510.1038/nri295721331081Search in Google Scholar
Winter J, Jukng S, Keller S, Gregory RI, Diederich S. Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol. 2009; 11:228–34.WinterJJukngSKellerSGregoryRIDiederichSMany roads to maturity: microRNA biogenesis pathways and their regulation2009112283410.1038/ncb0309-22819255566Search in Google Scholar
Ma Y, Wang J, Wang Y, Yang G-Y. The biphasic function of microglia in ischemic stroke. Prog Neurobiol. 2017; 157:247–72.MaYWangJWangYYangG-YThe biphasic function of microglia in ischemic stroke20171572477210.1016/j.pneurobio.2016.01.00526851161Search in Google Scholar
Bhalala OG, Srikanth M, Kessler JA. The emerging roles of microRNAs in CNS injuries. Nat Rev Neurol. 2013; 9:328–39.BhalalaOGSrikanthMKesslerJAThe emerging roles of microRNAs in CNS injuries201393283910.1038/nrneurol.2013.67375589523588363Search in Google Scholar
Zhang L, Huang J, Yang N, Greshock J, Megraw MS, Giannakakis A, et al. MicroRNAs exhibit high frequency genomic alterations in human cancer. Proc Natl Acad Sci USA. 2006; 103:9136–41.ZhangLHuangJYangNGreshockJMegrawMSGiannakakisAMicroRNAs exhibit high frequency genomic alterations in human cancer200610391364110.1073/pnas.0508889103147400816754881Search in Google Scholar
Davidson-Moncada J, Papavasiliou FN, Tam W. MicroRNAs of the immune system. Roles in inflammation and cancer. Ann N Y Acad Sci. 2010; 1183:183–94.Davidson-MoncadaJPapavasiliouFNTamWMicroRNAs of the immune system. Roles in inflammation and cancer201011831839410.1111/j.1749-6632.2009.05121.x287671220146715Search in Google Scholar
Taganov KD, Boldin MP, Chang K-J, Baltimore D. NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci USA. 2006; 103:12481–86.TaganovKDBoldinMPChangK-JBaltimoreDNF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses2006103124818610.1073/pnas.0605298103156790416885212Search in Google Scholar
Hashemi M, Eskandari-Nasab E, Zakeri Z, Atabaki M, Bahari G, et al. Association of premiRNA-146a rs2910164 and pre-miRNA-499 rs3746444 polymorphisms and susceptibility to rheumatoid arthritis. Mol Med Rep. 2013; 7:287–91.HashemiMEskandari-NasabEZakeriZAtabakiMBahariGAssociation of premiRNA-146a rs2910164 and pre-miRNA-499 rs3746444 polymorphisms and susceptibility to rheumatoid arthritis201372879110.3892/mmr.2012.117623138379Search in Google Scholar
Jazdzewski K, Murray EL, Franssila K, Jarzab B, Schoenberg DR, de la Chapelle A. Common SNP in premiR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma. Proc Natl Acad Sci USA. 2008; 105:7269–74.JazdzewskiKMurrayELFranssilaKJarzabBSchoenbergDRde la ChapelleACommon SNP in premiR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma200810572697410.1073/pnas.0802682105243823918474871Search in Google Scholar
Xiong XD, Cho M, Cai XP, Cheng J, Jing X, Cen JM, et al. A common variant in pre-miR-146 is associated with coronary artery disease risk and its mature miRNA expression. Mutat Res Fund Mol. 2014; 761:15–20.XiongXDChoMCaiXPChengJJingXCenJMA common variant in pre-miR-146 is associated with coronary artery disease risk and its mature miRNA expression2014761152010.1016/j.mrfmmm.2014.01.00124447667Search in Google Scholar
Guo M, Mao X, Ji Q, Lang M, Li S, Peng Y, et al. miR146a in PBMCs modulates Th1 function in patients with acute coronary syndrome. Immunol Cell Biol. 2010; 88:555–64.GuoMMaoXJiQLangMLiSPengYmiR146a in PBMCs modulates Th1 function in patients with acute coronary syndrome2010885556410.1038/icb.2010.1620195282Search in Google Scholar
Dalmas E, Rouault C, Abdennour M, Rovere C, Rizkalla S, Bar-Hen A, et al. Variations in circulating inflammatory factors are related to changes in calorie and carbohydrate intakes early in the course of surgery-induced weight reduction. Am J Clin Nutr. 2011; 94:450–8.DalmasERouaultCAbdennourMRovereCRizkallaSBar-HenAVariations in circulating inflammatory factors are related to changes in calorie and carbohydrate intakes early in the course of surgery-induced weight reduction201194450810.3945/ajcn.111.01377121677057Search in Google Scholar
Paepegaey AC, Genser L, Bouillot J-L, Oppert J-M, Clément K, Poitou C. High levels of CRP in morbid obesity: the central role of adipose tissue and lessons for clinical practice before and after bariatric surgery. Surg Obes Relat Dis. 2015; 11:148–54.PaepegaeyACGenserLBouillotJ-LOppertJ-MClémentKPoitouCHigh levels of CRP in morbid obesity: the central role of adipose tissue and lessons for clinical practice before and after bariatric surgery2015111485410.1016/j.soard.2014.06.01025393045Search in Google Scholar
Irvin AE, Jhala G, Zhao Y, Blackwell TS, Krishnamurthy B, Thomas HE, Kay TWH. NF-κB is weakly activated in the NOD mouse model of type 1 diabetes. Sci Rep. 2018; 8:4217. doi: 10.1038/s41598-018-22738-3IrvinAEJhalaGZhaoYBlackwellTSKrishnamurthyBThomasHEKayTWHNF-κB is weakly activated in the NOD mouse model of type 1 diabetes20188421710.1038/s41598-018-22738-3Open DOISearch in Google Scholar
Meyerovich K, Ortis F, Cardozo AK. The non-canonical NF-κB pathway and its contribution to β-cell failure in diabetes. J Mol Endocrinol. 2018; 61:F1–6.MeyerovichKOrtisFCardozoAKThe non-canonical NF-κB pathway and its contribution to β-cell failure in diabetes201861F1610.1530/JME-16-0183Search in Google Scholar
Yenmis G, Soydas T, Arkan H, Tasan E, Kanigur Sultuybek G. Genetic variation in NFKB1 gene influences liver enzyme levels in morbidly obese women. Arch Iran Med. 2018; 21:13–18.YenmisGSoydasTArkanHTasanEKanigur SultuybekGGenetic variation in NFKB1 gene influences liver enzyme levels in morbidly obese women2018211318Search in Google Scholar
Stegger JG, Schmidt EB, Berentzen TL, Tjønneland A, Vogel U, Rimm E, et al. Interaction between obesity and the NFKB1 – 94ins/delATTG promoter polymorphism in relation to incident acute coronary syndrome: a follow up study in three independent cohorts. PLoS One. 2013; 8:1–8.SteggerJGSchmidtEBBerentzenTLTjønnelandAVogelURimmEInteraction between obesity and the NFKB1 – 94ins/delATTG promoter polymorphism in relation to incident acute coronary syndrome: a follow up study in three independent cohorts201381810.1371/journal.pone.0063004Search in Google Scholar
Soydas T, Karaman O, Arkan H, Yenmis G, Ilhan MM, Tombulturk K, et al. The correlation of increased CRP levels with NFKB1 and TLR2 polymorphisms in the case of morbid obesity. Scand J Immunol. 2016; 84:278–3.SoydasTKaramanOArkanHYenmisGIlhanMMTombulturkKThe correlation of increased CRP levels with NFKB1 and TLR2 polymorphisms in the case of morbid obesity201684278310.1111/sji.12471Search in Google Scholar
Guzick DS, Overstreet JW, Factor-Litvak P, Brazil CK, Nakajima ST, Coutifaris C, et al. Sperm morphology, motility, and concentration in fertile and infertile men. N Engl J Med. 2001; 345:1388–93.GuzickDSOverstreetJWFactor-LitvakPBrazilCKNakajimaSTCoutifarisCSperm morphology, motility, and concentration in fertile and infertile men200134513889310.1056/NEJMoa003005Search in Google Scholar
Carlsen H, Alexander G, Austenaa LMI, Ebihara K, Blomhoff R. Molecular imaging of the transcription factor NF-kB, a primary regulator of stress response. Mutat Res. 2004; 551:199–211.CarlsenHAlexanderGAustenaaLMIEbiharaKBlomhoffRMolecular imaging of the transcription factor NF-kB, a primary regulator of stress response200455119921110.1016/j.mrfmmm.2004.02.024Search in Google Scholar
Yamamoto Y, Gaynor RB. IκB kinases: key regulators of the NF-κB pathway. Trends Biochem Sci 2004; 29:72–9.YamamotoYGaynorRBIκB kinases: key regulators of the NF-κB pathway20042972910.1016/j.tibs.2003.12.003Search in Google Scholar
Ranganathan P, Kattal N, Moustafa MH, Sharma RK, Thomas AJ Jr, Agarwal A. Correlation of nuclear factor kappa B (NFKB) with sperm quality and clinical diagnoses in infertile men. Fertil Steril. 2002; 78:S95 [abstract]RanganathanPKattalNMoustafaMHSharmaRKThomasAJJrAgarwalACorrelation of nuclear factor kappa B (NFKB) with sperm quality and clinical diagnoses in infertile men200278S95[abstract]10.1016/S0015-0282(02)03631-2Search in Google Scholar
Solanas G, Porta-de-la-Riva M, Agustí C, Casagolda D, Sánchez-Aguilera F, Larriba MJ, et al. E-Cadherin controls β-catenin and NF-κB transcriptional activity in mesenchymal gene expression. J Cell Sci. 2008; 121:2224–34.SolanasGPorta-de-la-RivaMAgustíCCasagoldaDSánchez-AguileraFLarribaMJE-Cadherin controls β-catenin and NF-κB transcriptional activity in mesenchymal gene expression200812122243410.1242/jcs.021667Search in Google Scholar
Aberle H, Schwartz H, Kemler R. Cadherin-catenin complex: protein interactions and their implications for cadherin function. J Cell Biochem. 1996; 61:514–23.AberleHSchwartzHKemlerRCadherin-catenin complex: protein interactions and their implications for cadherin function1996615142310.1002/(SICI)1097-4644(19960616)61:4<514::AID-JCB4>3.0.CO;2-RSearch in Google Scholar
Hernandez Gifford JA, Hunzicker-Dunn ME, Nilson JH. Conditional deletion of beta-catenin mediated by Amhr2cre in mice causes female infertility. Biol Reprod. 2009; 80:1282–92.Hernandez GiffordJAHunzicker-DunnMENilsonJHConditional deletion of beta-catenin mediated by Amhr2cre in mice causes female infertility20098012829210.1095/biolreprod.108.072280280480519176883Search in Google Scholar
Purohit S, Brahmaraju M, Palta A, Shukla S, Laloraya M, Kumar PG. Impaired E-Cadherin expression in human spermatozoa in a male factor infertility subset signifies e-cadherin-mediated adhesion mechanisms operative in sperm–oolemma interactions. Biochem Biophys Res Commun. 2004; 316:903–9.PurohitSBrahmarajuMPaltaAShuklaSLalorayaMKumarPGImpaired E-Cadherin expression in human spermatozoa in a male factor infertility subset signifies e-cadherin-mediated adhesion mechanisms operative in sperm–oolemma interactions2004316903910.1016/j.bbrc.2004.02.13315033487Search in Google Scholar
Tunçdemir M, Yenmiş G, Tombultürk K, Arkan H, Soydaş T, Tek RB, et al. NFKB1 rs28362491 and pre-miRNA-146a rs2910164 SNPs on E-Cadherin expression in case of idiopathic oligospermia: a case-control study. Int J Reprod BioMed (Yazd). 2018; 16:247–54.TunçdemirMYenmişGTombultürkKArkanHSoydaşTTekRBNFKB1 rs28362491 and pre-miRNA-146a rs2910164 SNPs on E-Cadherin expression in case of idiopathic oligospermia: a case-control study2018162475410.29252/ijrm.16.4.247Search in Google Scholar
Tek B, Elçin P, Tunçdemir M, Onaran İ, Özkara H, Kanıgür Sultuybek G. A role for heterozygosity of NF-κB1 rs28362491 polymorphism in patients with idiopathic oligospermia. Arch Iran Med. 2016; 19:275–81.TekBElçinPTunçdemirMOnaranİÖzkaraHKanıgür SultuybekGA role for heterozygosity of NF-κB1 rs28362491 polymorphism in patients with idiopathic oligospermia20161927581Search in Google Scholar
Elcin P, Burak Tek R, Koc A, Arkan H, Ozkara H, Kanigur-Sultuybek G. Effects of SNPs in nuclear factor kappa-B1, poly (ADP-ribose) polymerase-1 genes on E-Cadherin and fibronectin levels in case of male infertility. Androl Gynecol Curr Res. 2015;3:1–7.ElcinPBurak TekRKocAArkanHOzkaraHKanigur-SultuybekGEffects of SNPs in nuclear factor kappa-B1, poly (ADP-ribose) polymerase-1 genes on E-Cadherin and fibronectin levels in case of male infertility2015317Search in Google Scholar
Wang X, Ma N, Sun Q, Huang C, Liu Y, Luo X. Elevated NF-κB signaling in Asherman syndrome patients and animal models. Oncotarget. 2017; 8:15399–406.WangXMaNSunQHuangCLiuYLuoXElevated NF-κB signaling in Asherman syndrome patients and animal models201781539940610.18632/oncotarget.14853536249428148903Search in Google Scholar
Chistiakov DA. Immunogenetics of Hashimoto's thyroiditis. J Autoimmune Dis. 2005; 2:1. doi: 10.1186/1740-2557-2-1ChistiakovDAImmunogenetics of Hashimoto's thyroiditis20052110.1186/1740-2557-2-155585015762980Open DOISearch in Google Scholar
Koc A, Aydin Sayitoglu M, Karakurt F, Batar B, Niyazoglu M, Celik O, et al. Association of three SNPs in the PARP-1 gene with Hashimoto's thyroiditis. Hum Genome Var. 2014; 1:14016. doi: 10.1038/hgv.2014.16KocAAydin SayitogluMKarakurtFBatarBNiyazogluMCelikOAssociation of three SNPs in the PARP-1 gene with Hashimoto's thyroiditis201411401610.1038/hgv.2014.16478552227081507Open DOISearch in Google Scholar
Koc A, Batar B, Celik O, Onaran I, Tasan E, Sultuybek GK. Polymorphism of the NFKB1 affects the serum inflammatory levels of IL-6 in Hashimoto thyroiditis in a Turkish population. Immunobiology. 2014; 219:531–6.KocABatarBCelikOOnaranITasanESultuybekGKPolymorphism of the NFKB1 affects the serum inflammatory levels of IL-6 in Hashimoto thyroiditis in a Turkish population2014219531610.1016/j.imbio.2014.03.00924703107Search in Google Scholar
Niyazoglu M, Baykara O, Koc A, Aydoğdu P, Onaran I, Dellal FD, et al. Association of PARP-1, NF-κB, NF-κBIA and IL-6, IL-1β and TNF-α with Graves disease and Graves ophthalmopathy. Gene. 2014; 547:226–32.NiyazogluMBaykaraOKocAAydoğduPOnaranIDellalFDAssociation of PARP-1, NF-κB, NF-κBIA and IL-6, IL-1β and TNF-α with Graves disease and Graves ophthalmopathy20145472263210.1016/j.gene.2014.06.03824956560Search in Google Scholar
Kurylowicz A, Miśkiewicz P, Bar-Andziak E, Nauman J, Bednarczuk T. Association of polymorphism in genes encoding κB inhibitors (IκB) with susceptibility to and phenotype of Graves’ disease: a case-control study. Thyroid Res. 2009; 2:10. doi: 10.1186/1756-6614-2-10KurylowiczAMiśkiewiczPBar-AndziakENaumanJBednarczukTAssociation of polymorphism in genes encoding κB inhibitors (IκB) with susceptibility to and phenotype of Graves’ disease: a case-control study200921010.1186/1756-6614-2-10277784419886988Open DOISearch in Google Scholar
Kaya Tİ. Genetics of Behçet's disease. Patholog Res Int. 2012; 2012:912589. doi: 10.1155/2012/912589KayaTİGenetics of Behçet's disease20122012912589.10.1155/2012/912589319543622013548Open DOISearch in Google Scholar
Yenmis G, Oner T, Cam C, Koc A, Kucuk OS, Yakicier MC, et al. Association of NFKB1 and NFKBIA polymorphisms in relation to susceptibility of Behçet's disease. Scand J Immunol. 2014; 81:81–6.YenmisGOnerTCamCKocAKucukOSYakicierMCAssociation of NFKB1 and NFKBIA polymorphisms in relation to susceptibility of Behçet's disease20148181610.1111/sji.1225125367031Search in Google Scholar
Kına I, Kanigur Sultuybek G, Soydas T, Yenmis G, Biceroglu H, Dirican A, et al. Variations in Toll-like receptor and nuclear factor-kappa B genes and the risk of glioma. Br J Neurosurg. 2019; 33:165–70.KınaIKanigur SultuybekGSoydasTYenmisGBicerogluHDiricanAVariations in Toll-like receptor and nuclear factor-kappa B genes and the risk of glioma2019331657010.1080/02688697.2018.154076430450997Search in Google Scholar
Hung Y-H, Wu C-C, Ou T-T, Lin C-H, Li R-N, Lin Y-C, et al. IκBα promoter polymorphisms in patients with Behçet's disease. Dis Markers. 2010; 28:55–62.HungY-HWuC-COuT-TLinC-HLiR-NLinY-CIκBα promoter polymorphisms in patients with Behçet's disease201028556210.1155/2010/305953Search in Google Scholar
Kaustio M, Haapaniemi E, Göös H, Hautala T, Park G, Syrjänen J, et al. Damaging heterozygous mutations in NFKB1 lead to diverse immunologic phenotypes. J Allergy Clin Immunol. 2017; 140:782–96.KaustioMHaapaniemiEGöösHHautalaTParkGSyrjänenJDamaging heterozygous mutations in NFKB1 lead to diverse immunologic phenotypes20171407829610.1016/j.jaci.2016.10.05428115215Search in Google Scholar
Terzić J, Grivennikov S, Karin E, Karin M. Inflammation and colon cancer. Gastroenterology. 2010; 138:2101–14.e5.TerzićJGrivennikovSKarinEKarinMInflammation and colon cancer2010138210114.e510.1053/j.gastro.2010.01.05820420949Search in Google Scholar
Vlahopoulos SA, Cen O, Hengen N, Agan J, Moschovi M, Critselis E, et al. Dynamic aberrant NF-κB spurs tumorigenesis: a new model encompassing the microenvironment. Cytokine Growth Factor Rev. 2015; 26:389–403.VlahopoulosSACenOHengenNAganJMoschoviMCritselisEDynamic aberrant NF-κB spurs tumorigenesis: a new model encompassing the microenvironment20152638940310.1016/j.cytogfr.2015.06.001452634026119834Search in Google Scholar
Grivennikov S, Karin M. Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer. Cytokine Growth Factor Rev. 2010; 21:11–19.GrivennikovSKarinMDangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer201021111910.1016/j.cytogfr.2009.11.005283486420018552Search in Google Scholar
Reardon DA, Wen PY. Therapeutic advances in the treatment of glioblastoma: rationale and potential role of targeted agents. Oncologist. 2006; 11:152–64.ReardonDAWenPYTherapeutic advances in the treatment of glioblastoma: rationale and potential role of targeted agents2006111526410.1634/theoncologist.11-2-15216476836Search in Google Scholar
Maes W, Van Gool SW. Experimental immuno-therapy for malignant glioma: lessons from two decades of research in the GL261 model. Cancer Immunol Immunother. 2011; 60:153–60.MaesWVan GoolSWExperimental immuno-therapy for malignant glioma: lessons from two decades of research in the GL261 model2011601536010.1007/s00262-010-0946-621120655Search in Google Scholar
Furnari FB, Fenton T, Bachoo RM, Mukasa A, Stommel JM, Stegh A, et al. Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev. 2007; 21:2683–710.FurnariFBFentonTBachooRMMukasaAStommelJMSteghAMalignant astrocytic glioma: genetics, biology, and paths to treatment200721268371010.1101/gad.159670717974913Search in Google Scholar
Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 2008; 455:1061–8.Cancer Genome Atlas Research NetworkComprehensive genomic characterization defines human glioblastoma genes and core pathways20084551061810.1038/nature07385267164218772890Search in Google Scholar
Szajnik M, Szczepanski MJ, Czystowska M, Elishaev E, Mandapathil M, Nowak-Markwitz E, et al. TLR4 signaling induced by lipopolysaccharide or paclitaxel regulates tumour survival and chemoresistance in ovarian cancer. Oncogene 2009; 28:4353–63.SzajnikMSzczepanskiMJCzystowskaMElishaevEMandapathilMNowak-MarkwitzETLR4 signaling induced by lipopolysaccharide or paclitaxel regulates tumour survival and chemoresistance in ovarian cancer20092843536310.1038/onc.2009.289279499619826413Search in Google Scholar
Kim S, Karin M. Role of TLR2-dependent inflammation in metastatic progression. Ann N Y Acad Sci. 2011; 1217:191–206.KimSKarinMRole of TLR2-dependent inflammation in metastatic progression2011121719120610.1111/j.1749-6632.2010.05882.x438309421276007Search in Google Scholar
Wang H, Cho CH. Effect of NF-κB signaling on apoptosis in chronic inflammation-associated carcinogenesis. Curr Cancer Drug Targets. 2010; 10:593–9.WangHChoCHEffect of NF-κB signaling on apoptosis in chronic inflammation-associated carcinogenesis201010593910.2174/15680091079185942520482486Search in Google Scholar
Hegazy DM, O’Reilly DA, Yang BM, Hodgkinson AD, Millward BA, Demaine AG. NFκB polymorphisms and susceptibility to type 1 diabetes. Genes Immun. 2001; 2:304–8.HegazyDMO’ReillyDAYangBMHodgkinsonADMillwardBADemaineAGNFκB polymorphisms and susceptibility to type 1 diabetes20012304810.1038/sj.gene.636377611607785Search in Google Scholar
Sun XF, Zhang H. NFKB and NFKBI polymorphisms in relation to susceptibility of tumour and other diseases. Histol Histopathol. 2007; 22:1387–98.SunXFZhangHNFKB and NFKBI polymorphisms in relation to susceptibility of tumour and other diseases200722138798Search in Google Scholar
Yu Y, Wan Y, Huang C. The biological functions of NF-kB1 (p50) and its potential as an anti-cancer target. Curr Cancer Drug Targ. 2009; 9:566–71.YuYWanYHuangCThe biological functions of NF-kB1 (p50) and its potential as an anti-cancer target200995667110.2174/156800909788486759374782019519322Search in Google Scholar
Yang X, Li P, Tao J, Qin C, Cao Q, Gu J, et al. Association between NFKB1 –94ins/del ATTG promoter polymorphism and cancer susceptibility: an updated meta-analysis. Int J Genomics. 2014; 2014:612972. doi: 10.1155/2014/612972YangXLiPTaoJQinCCaoQGuJAssociation between NFKB1 –94ins/del ATTG promoter polymorphism and cancer susceptibility: an updated meta-analysis2014201461297210.1155/2014/612972403354724895544Open DOISearch in Google Scholar
Concetti J, Wilson CL. NFKB1 and cancer: friend or foe? Cells. 2018; 7:133. doi: 10.3390/cells7090133ConcettiJWilsonCLNFKB1 and cancer: friend or foe?2018713310.3390/cells7090133616271130205516Open DOISearch in Google Scholar
Fu W, Zhuo Z-J, Chen Y-C, Zhu J, Zhao Z, Jia W, et al. NFKB1 -94insertion/deletion ATTG polymorphism and cancer risk: evidence from 50 case-control studies. Oncotarget. 2017; 8: 9806–22.FuWZhuoZ-JChenY-CZhuJZhaoZJiaWNFKB1 -94insertion/deletion ATTG polymorphism and cancer risk: evidence from 50 case-control studies2017898062210.18632/oncotarget.14190535477228039461Search in Google Scholar
Li L, Zhang ZT. Genetic association between NFKBIA and NFKB1 gene polymorphisms and the susceptibility to head and neck cancer: a meta-analysis. Dis Markers. 2019; 2019:6523837. doi: 10.1155/2019/6523837LiLZhangZTGenetic association between NFKBIA and NFKB1 gene polymorphisms and the susceptibility to head and neck cancer: a meta-analysis201920196523837.10.1155/2019/6523837675724531612070Open DOISearch in Google Scholar
Simonian M, Mosallayi M, Miraghajani M, Feizi A, Khosravi S, Salehi AR, et al. Single nucleotide polymorphism rs696 in miR449a binding site of NFKBIA gene is correlated with risk of colorectal cancer. Gastroenterol Hepatol Bed Bench. 2018; 11:48–53.SimonianMMosallayiMMiraghajaniMFeiziAKhosraviSSalehiARSingle nucleotide polymorphism rs696 in miR449a binding site of NFKBIA gene is correlated with risk of colorectal cancer2018114853Search in Google Scholar
Westbrook AM, Szakmary A, Schiestl RH. Mechanisms of intestinal inflammation and development of associated cancers: lessons learned from mouse models. Mutat. Res. 2010; 705:40–59.WestbrookAMSzakmaryASchiestlRHMechanisms of intestinal inflammation and development of associated cancers: lessons learned from mouse models2010705405910.1016/j.mrrev.2010.03.001287886720298806Search in Google Scholar
Kanigur Sultuybek G, Soydas T, Yenmis G. NF-κB as the mediator of metformin's effect on ageing and ageing-related diseases. Clin Exp Pharmacol Physiol. 2019; 46:413–22.Kanigur SultuybekGSoydasTYenmisGNF-κB as the mediator of metformin's effect on ageing and ageing-related diseases2019464132210.1111/1440-1681.1307330754072Search in Google Scholar
Miller SC, Huang R, Sakamuru S, Shukla SJ, Attene-Ramos MS, Shinn P, et al. Identification of known drugs that act as inhibitors of NF-κB signaling and their mechanism of action. Biochem Pharmacol. 2010; 79:1272–80.MillerSCHuangRSakamuruSShuklaSJAttene-RamosMSShinnPIdentification of known drugs that act as inhibitors of NF-κB signaling and their mechanism of action20107912728010.1016/j.bcp.2009.12.021283487820067776Search in Google Scholar
Yamamoto M, Horie R, Takeiri M, Kozawa I, Umezawa K. Inactivation of NF-κB components by covalent binding of (–)-dehydroxymethylepoxyquinomicin to specific cysteine residues. J Med Chem. 2008; 51:5780–8.YamamotoMHorieRTakeiriMKozawaIUmezawaKInactivation of NF-κB components by covalent binding of (–)-dehydroxymethylepoxyquinomicin to specific cysteine residues2008515780810.1021/jm800624518729348Search in Google Scholar
Tak PP, Firestein GS. NF-κB: a key role in inflammatory diseases. J Clin Invest. 2001; 107:7–11.TakPPFiresteinGSNF-κB: a key role in inflammatory diseases200110771110.1172/JCI1183019855211134171Search in Google Scholar
Kiliccioglu I, Konac E, Dikmen AU, Sozen S, Bilen CY. Hsp-27 and NF-κB pathway is associated with AR/AR-V7 expression in prostate cancer cells. Gene. 2019; 697:138–43.KilicciogluIKonacEDikmenAUSozenSBilenCYHsp-27 and NF-κB pathway is associated with AR/AR-V7 expression in prostate cancer cells20196971384310.1016/j.gene.2019.02.05530807779Search in Google Scholar
Yenmis G. Investigation of the molecular mechanisms of the effect of metformin on aging and cancer [PhD dissertation]. Istanbul, Turkey: University of Istanbul; 2019. Thesis No. 541930. [in Turkish, English abstract]. Available from: https://tez.yok.gov.tr/UlusalTez-Merkezi/tezSorguSonucYeni.jspYenmisGIstanbul, TurkeyUniversity of Istanbul2019Thesis No. 541930. [in Turkish, English abstract]. Available from: https://tez.yok.gov.tr/UlusalTez-Merkezi/tezSorguSonucYeni.jspSearch in Google Scholar