Antimicrobial activity of some novel 2-(2-iodophenylimino)-5-arylidenethiazolidin-4-one derivatives
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10. Okt. 2018
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Artikel-Kategorie: Original article
Online veröffentlicht: 10. Okt. 2018
Seitenbereich: 405 - 412
DOI: https://doi.org/10.1515/abm-2018-0015
Schlüsselwörter
© 2017 Duy Toan Pham et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.
Scheme 1
Antimicrobial activity of the synthesized compounds, 3A–3L, on various strains of bacteria and fungi
| Structure | Name | R | Bacteria | Fungi | |||||
|---|---|---|---|---|---|---|---|---|---|
| E. coli | P. aeruginosa | E. faecalis | S. aureus | MRSA | C. albicans | A. niger | |||
| 2-(2-Iodophenylimino)-5- | |||||||||
| (4-methoxybenzylidene)thiazolidin- | 4”-OCH3 | − | − | − | >1024 | >1024 | − | − | |
| 4-one | |||||||||
| 2-(2-Iodophenylimino)-5- | |||||||||
| (4-chlorobenzylidene)thiazolidin- | 4”-Cl | − | − | − | 8 | 4 | − | − | |
| 4-one | |||||||||
| 2-(2-Iodophenylimino)-5- | |||||||||
| (2,4-dichlorobenzylidene)thiazoli- | 2”-Cl | − | − | − | >1024 | >1024 | − | − | |
| din-4-one | 4”-Cl | ||||||||
| 2-(2-Iodophenylimino)-5- | 4”-OH | ||||||||
| (4-hydroxy-3-methoxybenzylidene) | 3”-OCH | − | − | − | 16 | 16 | − | − | |
| thiazolidin-4-one | 3 | ||||||||
| 2-(2-Iodophenylimino)-5- | |||||||||
| (4-fluorobenzylidene)thiazolidin- | 4”-F | − | − | − | 8 | 8 | − | − | |
| 4-one | |||||||||
| 2-(2-Iodophenylimino)-5- | − | − | − | >1024 | >1024 | − | − | ||
| benzylidenethiazolidin-4-one | |||||||||
| 2-(2-Iodophenylimino)-5- | |||||||||
| (4-methylbenzylidene)thiazolidin- | 4”-CH3 | − | − | − | >1024 | 128 | − | − | |
| 4-one | |||||||||
| 2-(2-Iodophenylimino)-5- | |||||||||
| (4-nitrobenzylidene)thiazolidin- | 4”-NO2 | − | − | − | 8 | 8 | − | − | |
| 4-one | |||||||||
| 2-(2-Iodophenylimino)-5- | |||||||||
| (2-nitrobenzylidene)thiazolidin- | 2”-NO2 | − | − | >1024 | 8 | 32 | − | − | |
| 4-one | |||||||||
| 2-(2-Iodophenylimino)-5- | |||||||||
| (2-hydroxybenzylidene)thiazolidin- | 2”-OH | − | − | − | >1024 | >1024 | − | − | |
| 4-one | |||||||||
| 2-(2-Iodophenylimino)-5- | 2”-OH | ||||||||
| (5-bromo-2-hydroxybenzylidene) | 5”-Br | − | − | − | 64 | 64 | − | − | |
| thiazolidin-4-one | |||||||||
| 2-(2-Iodophenylimino)-5- | |||||||||
| (4-dimethylaminobenzylidene) | 4”-N(CH3)2 | − | − | − | − | – | − | − | |
| thiazolidin-4-one | |||||||||
| Cephalexin | 32 | 4 | 32 | ||||||