1. bookVolume 66 (2017): Issue 3 (September 2017)
Journal Details
License
Format
Journal
eISSN
2544-4646
First Published
04 Mar 1952
Publication timeframe
4 times per year
Languages
English
Open Access

Genetic Characterization of Human Enteroviruses Associated with Hand, Foot and Mouth Diseases in Poland, 2013–2016

Published Online: 27 Sep 2017
Volume & Issue: Volume 66 (2017) - Issue 3 (September 2017)
Page range: 405 - 409
Received: 03 Oct 2016
Accepted: 12 Jan 2017
Journal Details
License
Format
Journal
eISSN
2544-4646
First Published
04 Mar 1952
Publication timeframe
4 times per year
Languages
English
Abstract

The objective of the present study was to describe the molecular characteristics of enteroviruses associated with hand, food, and mouth disease (HFMD) in Poland. Clinical material from HFMD cases, that occurred during 2013–2016 were examined. It has been showed that coxsackievirus A6 (CVA6), CVA10 and CVA16 were circulating in the country. Phylogenetic analysis showed that Polish CVA6 strains were divided into two distinct clusters suggesting two independent introductions. This is the first report of CVA6 infections associated with HFMD in Poland. These results emphasize the need for continuous monitoring of HFMD and facilitation of the diagnosis using molecular approaches.

Keywords

Blomqvist S., P. Klemola, S. Kaijalainen, A. Paananen, M.L. Simonen, T. Vuorinen and M. Roivainen. 2010. Co-circulation of coxsackieviruses A6 and A10 in hand, foot and mouth disease outbreak in Finland. J. Clin. Virol. 48: 49–54. Search in Google Scholar

Cabrerizo M., D. Tarrago, C. Munoz-Almagro, E. Del Amo, M. Dominguez-Gil, J.M. Eiros, I. Lopez-Miragava, C. Perez, J. Reina, A. Otero and others. 2014. Molecular epidemiology of enterovirus 71, coxsackievirus A16 and A6 associated with hand, foot and mouth disease in Spain. Clin. Microbiol. Infect. 20: O150–156. Search in Google Scholar

Fujimoto T., S. Iizuka, M. Enomoto, K. Abe, K. Yamashita, N. Hanaoka, N. Okabe, H. Yoshida, Y. Yasui, M. Kobayashi andothers. 2012. Hand, foot, and mouth disease caused by coxasckie- virus A6, Japan, 2011. Emerg. Infect. Dis. 18: 337–339. Search in Google Scholar

Lei X., S. Cui, Z. Zhao and J. Wang. 2015. Etiology, pathogenesis, antivirals and vaccines of hand, foot, and mouth disease. National Science Review 2: 268–284. Search in Google Scholar

Leitch E.C., H. Harvala, I. Robertson, I. Ubillos, K. Templeton and P. Simmonds. 2009. Direct identification of human enterovirus serotypes in cerebrospinal fluid by amplification and sequencing of the VP1 region. J. Clin. Virol. 44: 119–124.10.1016/j.jcv.2008.11.01519135410 Search in Google Scholar

Lott J.P., K. Liu, M.L. Landry, W.A. Nix, M.S. Oberste, J. Bolognis and B. King. 2013. Atypical hand-foot-and-mouth disease associated with coxsackievirus A6 infection. J. Am. Acad. Dermatol. 69: 736–741.10.1016/j.jaad.2013.07.024584347724035209 Search in Google Scholar

Mirand A., C. Henquell, C. Archimbaud, S. Ughetto, D. Antona, J.L. Bailly and H. Peigue-Lafeuille. 2012. Outbreak of hand, foot and mouth disease/herpangina associated with coxsackievirus A6 and A10 infections in 2010, France: a large citywide, prospective observational study. Clin. Microbiol. Infect. 18: E110–118. Search in Google Scholar

Nsaibia S., S. Wagner, P. Ronde, J.M. Warter, P. Poindron, M. Aouni and O.M. Dorchies. 2007. The difficult-to-cultivate coxsackieviruses A can productively multiply in primary culture of mouse skeletal muscle. Virus Res. 123: 30–39.10.1016/j.virusres.2006.07.01616956688 Search in Google Scholar

Osterback R., T. Vuorinen, M. Linna, P. Susi, T. Hyypia and M. Waris. 2009. Coxsackievirus A6 and hand, foot, and mouth disease, Finland. Emerg. Infect. Dis. 15: 1485–1488.10.3201/eid1509.090438281985819788821 Search in Google Scholar

Puenpa J., T. Chieochansin, P. Linsuwanon, S. Korkong, S. Thong- komplew, P. Vichaiwattana, A. Theamboonlers and Y. Poovora- wan. 2013. Hand, foot, and mouth disease caused by coxsackievirus A6, Thailand, 2012. Emerg. Infect. Dis. 19:641–643.10.3201/eid1904.121666364742823631943 Search in Google Scholar

Sinclair C., E. Gaunt, P. Simmonds, D. Broomfield, N. Nwafor, L. Wellington, K. Templeton, L. Willocks, O. Schofield and H. Haravala. 2014. Atypical hand, foot, and mouth disease associated with coxsackievirus A6 infection, Edinburgh, United Kingdom, January to February 2014. Euro Surveill. 19: 20745. Search in Google Scholar

Tamura K., G. Stecher, D. Peterson, A. Filipski and S. Kumar S. 2013. MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. Mol. Biol. Evol. 30: 2725–2729.10.1093/molbev/mst197384031224132122 Search in Google Scholar

Wei S.H., Y.P. Huang, M.C. Liu, T.P. Tsou, H.C. Lin, C.Y. Tsai, Y.N. Chao, L.Y. Chang and C.M. Hsu. 2011. An outbreak of coxsackievirus A6 hand, foot, and mouth disease associated with onychomadesis in Taiwan, 2010. BMC Infect. Dis. 11: 346. Search in Google Scholar

WHO. 2004. Polio laboratory manual. World Health Organization, Geneva, Switzerland. Search in Google Scholar

Wieczorek M. and A. Krzysztoszek. 2016. Molecular characterization of enteroviruses associated with acute flaccid paralysis cases in Poland, 1999–2014. Pol. J. Microbiol. 65. Search in Google Scholar

Wu Y., A. Yeo, M.C. Phoon, E.L. Tan, C.L. Poh, S.H. Quak and V.T. Chow. 2010. The largest outbreak of hand, foot and mouth disease in Singapore in 2008: the role of enterovirus 71 and coxsackievirus A strains. Int. J. Infect. Dis. 14: e1076–1081.Search in Google Scholar

Recommended articles from Trend MD

Plan your remote conference with Sciendo