Trends of Bloodstream Infections in a University Greek Hospital during a Three-Year Period: Incidence of Multidrug-Resistant Bacteria and Seasonality in Gram-negative Predominance

Anderson D.J., R.W. Moehring, R. Sloane, K.E. Schmader, D.J. Weber, V.G. Fowler Jr., E. Smathers and D.J. Sexton. 2014. Bloodstream infections in community hospitals in the 21^st century: a multicenter cohort study. PLoS One. 9(3): e91713.10.1371/journal.pone.0091713395839124643200 Search in Google Scholar

Bouza C., T. Lopez-Cuadrado, Z. Saz-Parkinson and J.M. AmateBlanco. 2014. Epidemiology and recent trends of severe sepsis in Spain: a nationwide population-based analysis (2006–2011). BMC Infect. Dis. 14: 3863.10.1186/s12879-014-0717-7432780925528662 Search in Google Scholar

Braun E., K. Hussein, Y. Geffen, G. Rabino, Y. Bar-Lavie and M. Paul. 2014. Predominance of Gram-negative bacilli among patients with catheter-related bloodstream infections. Clin. Microbiol. Infect. 20(10): O627–629.10.1111/1469-0691.1256524461043 Search in Google Scholar

Chang C.J., C.J. Wu, H.C. Hsu, C.H. Wu, F.Y. Shih, S.W. Wang, Y.H. Wu, C.M. Chang, Y.F. Tu, C.H. Chi and others. 2015. Factors Associated with Blood Culture Contamination in the Emergency Department: Critical Illness, End-Stage Renal Disease, and Old Age. PLoS One. 10(10): e0137653.10.1371/journal.pone.0137653459812926448628 Search in Google Scholar

de Kraker M.E., V. Jarlier, J.C. Monen, O.E. Heuer, N. van de Sande and H. Grundmann. 2013. The changing epidemiology of bacteraemias in Europe: trends from the European Antimicrobial Resistance Surveillance System. Clin. Microbiol. Infect. 19(9): 860–868.10.1111/1469-0691.1202823039210 Search in Google Scholar

Drougka E., A. Foka, A. Liakopoulos, A. Doudoulakakis, E. Jelastopulu, V. Chini, A. Spiliopoulou, S. Levidiotou, T. Panagea, A. Vogiatzi and others. 2014. A 12-year survey of methicillinresistant Staphylococcus aureus infections in Greece: ST80-IV epidemic? Clin. Microbiol. Infect. 20(11): O796–803.10.1111/1469-0691.1262424750462 Search in Google Scholar

Eber M.R., M. Shardell, M.L. Schweizer, R. Laxminarayan and Search in Google Scholar

E.N. Perencevich. 2011. Seasonal and temperature-associated increases in gram-negative bacterial bloodstream infections among hospitalized patients. PLoS One. 6(9):e25298.10.1371/journal.pone.0025298318038121966489 Search in Google Scholar

European Food Safety Authority and European Centre for Disease Prevention and Control (EFSA and ECDC). 2015. The European Union Summary Report on Trends and Sources of Zoonoses, Zoonotic Agents and Food-borne Outbreaks in 2013. EFSA Journal. 13(1): 3991.10.2903/j.efsa.2015.3991 Search in Google Scholar

European Centre for Disease Prevention and Control (ECDC). 2013. Point prevalence survey of healthcare associated infections and antimicrobial use in European acute care hospitals. ECDC, Stockholm. Search in Google Scholar

European Committee on Antimicrobial Susceptibility Testing (EUCAST). 2015. Breakpoint tables for interpretation of MICs and zone diameters. Version 5.0. EUCAST. Search in Google Scholar

Falagas, M.E., N. Roussos and K.Z. Vardakas. 2010. Relative frequency of albicans and the various non-albicans Candida spp among candidemia isolates from inpatients in various parts of the world: a systematic review. Int. J. Infect. Dis. 14(11): e954–966.10.1016/j.ijid.2010.04.00620797887 Search in Google Scholar

Fisman D., E. Patrozou, Y. Carmeli, E. Perencevich, A.R. Tuite, L.A. Mermel and Geographical Variability of Bacteremia Study. 2014. Geographical variability in the likelihood of bloodstream infections due to gram-negative bacteria: correlation with proximity to the equator and health care expenditure. PLoS One. 9(12): e114548.10.1371/journal.pone.0114548427064125521300 Search in Google Scholar

Goto M. and M.N. Al-Hasan. 2013. Overall burden of bloodstream infection and nosocomial bloodstream infection in North America and Europe. Clin. Microbiol. Infect. 19(6): 501–509. Search in Google Scholar

Gubbels S., J. Nielsen, M. Voldstedlund, B. Kristensen, H.C. Schonheyder, C.M. Vandenbroucke-Grauls, M. Arpi, M.K. Bjornsdottir, J.D. Knudsen, R.B. Dessau and others. 2015. Utilization of blood cultures in Danish hospitals: a population-based descriptive analysis. Clin. Microbiol. Infect. 21(4): 344e313–321.10.1016/j.cmi.2014.11.01825658520 Search in Google Scholar

Hadziyannis A.S., I. Stephanou, K. Dimarogona, A. Pantazatou, D. Fourkas, D. Filiagouridis and A. Avlami. 2004. Blood culture results during the period 1995–2002 in a Greek tertiary care hospital. Clin. Microbiol. Infect. 10(7): 667–670.Search in Google Scholar

Horan T.C., M. Andrus and M.A. Dudeck. 2008. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am. J. Infect. Control. 36(5): 309–332. Search in Google Scholar

Jelastopulu E., C. Bikas, C. Petropoulos and M. Leotsinidis. 2008. Incidence of human brucellosis in a rural area in Western Greece after the implementation of a vaccination programme against animal brucellosis. BMC Public Health. 8: 241.10.1186/1471-2458-8-241248397718637172 Search in Google Scholar

Kang C.K., E.S. Kim, K.H. Song, H.B. Kim, T.S. Kim, N.H. Kim, C.J. Kim, P.G. Choe, J.H. Bang, W.B. Park and others. 2013. Can a routine follow-up blood culture be justified in Klebsiella pneumoniae bacteremia? A retrospective case-control study. BMC Infect. Dis. 13: 365.10.1186/1471-2334-13-365373421123914899 Search in Google Scholar

Karagiannis I., K. Mellou, K. Gkolfinopoulou, G. Dougas, G. Theocharopoulos, D. Vourvidis, D. Ellinas, M. Sotolidou, T. Papadimitriou and R. Vorou. 2012. Outbreak investigation of brucellosis in Thassos, Greece, 2008. Euro Surveill. 17(11):pii: 2011610.2807/ese.17.11.20116-enSearch in Google Scholar

Karchmer A.W. 2000. Nosocomial bloodstream infections: organisms, risk factors, and implications. Clin. Infect. Dis. 31(Suppl 4): S139–143. Search in Google Scholar

Khatib R., G. Simeunovic, M. Sharma, M.G. Fakih, L.B. Johnson, L. Briski and W. Lebar. 2015. Blood culture series benefit may be limited to selected clinical conditions: time to reassess. Clin. Microbiol. Infect. 21(4): 332–336.10.1016/j.cmi.2014.11.01925658519 Search in Google Scholar

Kitaura T., H. Chikumi, H. Fujiwara, K. Okada, T. Hayabuchi, M. Nakamoto, M. Takata, A. Yamasaki, T. Igishi, N. Burioka and thers. 2014. Positive predictive value of true Bacteremia according to the number of positive culture sets in adult patients. Yonago Acta Med. 57(4): 159–165. Search in Google Scholar

Koupetori M., T. Retsas, N. Antonakos, G. Vlachogiannis, I. Perdios, C. Nathanail, K. Makaritsis, A. Papadopoulos, D. Sinapidis, E.J. Giamarellos-Bourboulis and others. 2014. Bloodstream infections and sepsis in Greece: over-time change of epidemiology and impact of de-escalation on final outcome. BMC Infect. Dis. 14: 272.10.1186/1471-2334-14-272403582724885072 Search in Google Scholar

Papadimitriou-Olivgeri I., N. Giormezis, M. Papadimitriou-Olivgeris, A. Zotou, F. Kolonitsiou, K. Koutsileou, F. Fligou, M. Marangos, E.D. Anastassiou and I. Spiliopoulou. 2015. Number of positive blood cultures, biofilm formation, and adhesin genes in differentiating true coagulase-negative staphylococci bacteremia from contamination. Eur. J. Clin. Microbiol. Infect. Dis. 35(1): 57–66Search in Google Scholar

Papadimitriou-Olivgeris M., M. Marangos, M. Christofidou, Search in Google Scholar

F. Fligou, C. Bartzavali, E.S. Panteli, S. Vamvakopoulou, K.S. Filos and E.D. Anastassiou. 2014a. Risk factors for infection and predictors of mortality among patients with KPC-producing Klebsiella pneumoniae bloodstream infections in the intensive care unit. Scand. J. Infect. Dis. 46(9): 642–648.10.3109/00365548.2014.92310625017796 Search in Google Scholar

Papadimitriou-Olivgeris M., A. Spiliopoulou, F. Fligou, P. Manolopoulou, I. Spiliopoulou, T. Vrettos, V. Dodou, K.S. Filos, E.D. Anastassiou, M. Marangos and others. 2014b. Association of KPC-producing Klebsiella pneumoniae colonization or infection with Candida isolation and selection of non-albicans species. Diagn. Microbiol. Infect. Dis. 80(3): 227–232.10.1016/j.diagmicrobio.2014.07.01225175179 Search in Google Scholar

Papadimitriou-Olivgeris M., F. Kolonitsiou, L. Zerva, E. Lebessi, C. Koutsia, E. Drougka, S. Sarrou, N. Giormezis, S. Vourli, A. Doudoulakakis and others. 2015. Activity of vancomycin, linezolid, and daptomycin against staphylococci and enterococci isolated in 5 Greek hospitals during a 5-year period (2008–2012). Diagn. Microbiol. Infect. Dis. 83(4): 386–388. Search in Google Scholar

Paul M. 2012. Seasonality in infectious diseases: does it exist for all pathogens? Clin. Microbiol. Infect. 18(10): 925–926. Search in Google Scholar

Pereira C.A., A.R. Marra, L.F. Camargo, A.C. Pignatari, T. Sukiennik, P.R. Behar, E.A. Medeiros, J. Ribeiro, E. Girao, L. Correa, and others. 2013. Nosocomial bloodstream infections in Brazilian pediatric patients: microbiology, epidemiology, and clinical features. PLoS One. 8(7): e68144. Search in Google Scholar

Queenan A.M. and K. Bush. 2007. Carbapenemases: the versatile beta-lactamases. Clin. Microbiol. Rev. 20(3): 440–458, table of contents.10.1128/CMR.00001-07193275017630334 Search in Google Scholar

Rodriguez-Creixems M., P. Munoz, P. Martin-Rabadan, E. Cercenado, M. Guembe and E. Bouza. 2013. Evolution and aetiological shift of catheter-related bloodstream infection in a whole institution: the microbiology department may act as a watchtower. Clin. Microbiol. Infect. 19(9): 845–851.10.1111/1469-0691.1205023565810 Search in Google Scholar

Schwab F., P. Gastmeier and E. Meyer. 2014. The warmer the weather, the more Gram-negative bacteria – impact of temperature on clinical isolates in intensive care units. PLoS One, 9(3): e91105. Search in Google Scholar

Spiliopoulou A., S. Vamvakopoulou, C. Bartzavali, G. Dimitracopoulos, E.D. Anastassiou and M. Christofidou. 2010. Eleven-year retrospective survey of candidaemia in a university hospital in southwestern Greece. Clin. Microbiol. Infect. 16(9): 1378–1381. Search in Google Scholar

Tsakris A., A. Poulou, S. Pournaras, E. Voulgari, G. Vrioni, K. Themeli-Digalaki, D. Petropoulou and D. Sofianou. 2010. A simple phenotypic method for the differentiation of metallo-betalactamases and class A KPC carbapenemases in Enterobacteriaceae clinical isolates. J. Antimicrob. Chemother. 65(8): 1664–1671. Search in Google Scholar

Urban E. 2012. Five-year retrospective epidemiological survey of anaerobic bacteraemia in a university hospital and rewiew of the literature. Eur. J. Microbiol. Immunol. (Bp) 2(2):140–147. Search in Google Scholar

Uyanik M.H., H. Yazgi, K. Ozden, Z. Erdil and A. Ayyildiz. 2014. Comparison of coagulase-negative staphylococci isolated from blood cultures as a true bacteremia agent and contaminant in terms of slime production and methicillin resistance. Eurasian J. Med. 46(2): 115–119. Search in Google Scholar

Wisplinghoff H., T. Bischoff, S.M. Tallent, H. Seifert, R.P. Wenzel and M.B. Edmond. 2004. Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin. Infect. Dis. 39(3): 309–317.Search in Google Scholar