In Search of the Antimicrobial Potential of Benzimidazole Derivatives

Andrzejewska M., L. Yepez-Mulia, A. Tapia, R. Cedillo-Rivera, A.E. Laudy, B.J. Starościak and Z. Kazimierczuk. 2004. Synthesis, and antiprotozoal and antibacterial activities of S-substituted 4,6-dibromo- and 4,6-dichloro-2-mercaptobenzimidazoles. Eur. J. Pharm. Sci. 21: 323–329. Search in Google Scholar

Bansal Y. and O. Silakari. 2012. The therapeutic journey of benzimidazoles: a review. Bioorg. Med. Chem. 20: 6208–6236.10.1016/j.bmc.2012.09.01323031649 Search in Google Scholar

Gaba M., S. Singh and C. Mohan. 2014. Benzimidazole: an emerging scaffold for analgesic and anti-inflammatory agents. Eur. J. Med. Chem. 76: 494–505.10.1016/j.ejmech.2014.01.03024602792 Search in Google Scholar

Gianoncelli A., G. Cozza, A. Orzeszko, F. Meggio, Z. Kazimier- czuk and L. A. Pinna. 2009. Tetraiodobenzimidazoles are potent inhibitors of protein kinase CK2. Bioorg. Med. Chem. 17: 7281–7289.10.1016/j.bmc.2009.08.04719748274Search in Google Scholar

Horton D.A., G.T. Bourne and M. L. Smythe. 2003. The combinatorial synthesis of bicyclic privileged structures or privileged substructures. Chem. Rev. 103: 893–930.10.1021/cr020033s12630855 Search in Google Scholar

Janeczko M., A. Orzeszko, Z. Kazimierczuk, R. Szyszka and A. Baier. 2012. CK2α and CK2α’ subunits differ in their sensitivity to 4,5,6,7-tetrabromo- and 4,5,6,7-tetraiodo-1H-benzimidazole derivatives. Eur. J. Med. Chem. 47: 345–350. Search in Google Scholar

Kaplancikli Z.A., G. Turan-Zitouni, G. Revial and K. Guven. 2004. Synthesis and study of antibacterial and antifungal activities of novel 2-[[(benzoxazole/benzimidazole-2-yl)sulfanyl] acetylamino] thiazoles. Arch. Pharm. Res. 27: 1081–1085.10.1007/BF0297510815595406 Search in Google Scholar

Karpińka M.M., J. Matysiak and A. Niewiadomy. 2011 . Synthesis of novel 4-(1H-benzimidazol-2-yl)benzene-1,3-diols and their cytotoxic activity against human cancer cell lines. Arch. Pharm. Res. 34: 1639–1647. Search in Google Scholar

Karpińska M.M., J. Matysiak, A. Niewiadomy, J. Wietrzyk and D. Kłopotowska. 2012. Synthesis and biological activity of novel 4- and 6-(1-alkyl/aryl-1H-benzimidazol-2-yl)benzene-1,3-diols Mona tshefte für Chemie 143: 269–276.10.1007/s00706-011-0665-5 Search in Google Scholar

Kazimierczuk Z., M. Andrzejewska, J. Kaustova and V. Klimesova. 2005. Synthesis and antimycobacterial activity of 2-substituted halogenobenzimidazoles. Eur. J. Med. Chem. 40: 203–208.10.1016/j.ejmech.2004.10.00415694655 Search in Google Scholar

Küçükbay H., R. Durmaz, N. Okyucu and S. Günal. 2003a. Antifungal activity of some bis-5-methylbenzimidazole compounds. Folia Microbiol (Praha) 48: 679–681.10.1007/BF0299347814976728 Search in Google Scholar

Küçükbay H., R. Durmaz, E. Orhan and S. Günal. 2003b. Synthesis, antibacterial and antifungal activities of electron-rich olefins derived benzimidazole compounds. Farmaco 58: 431–437. Search in Google Scholar

Laudy A.E., R. Moo-Puc, R. Cedillo-Rivera, Z. Kazimierczuk and A. Orzeszko. 2012. Synthesis and antimicrobial activities of new polyhalogenated benzimidazoles. Journal of Heterocyclic Chemistry 49: 1059–1063.10.1002/jhet.936 Search in Google Scholar

Los R., M. Wesołowska-Trojanowska, A.M. Malm, M. Karpińska, J. Matysiak, A. Niewiadomy and U. Głaszcz. 2012. A new approach to the synthesis of 2-aryl-substituted benzimidazoles, quinazolines, and other related compounds and their antibacterial activity. Heteroatom Chemistry 23:265–275.10.1002/hc.21012 Search in Google Scholar

Martin R.J. 1997. Modes of action of anthelmintic drugs. Vet. J. 154: 11–34.10.1016/S1090-0233(05)80005-X Search in Google Scholar

Navarrete-Vázquez G., M.e.M. Rojano-Vilchis, L. Yépez-Mulia, V. Meléndez, L. Gerena, A. Hernández-Campos, R. Castillo and F. Hernández-Luis. 2006. Synthesis and antiprotozoal activity of some 2-(trifluoromethyl)-1H-benzimidazole bioisosteres. Eur. J. Med. Chem. 41:135–141.10.1016/j.ejmech.2005.09.00116260067 Search in Google Scholar

Padmavathi V., P. Thriveni, G. Sudhakar Reddy and D. Deepti. 2008. Synthesis and antimicrobial activity of novel sulfone-linked bis heterocycles. Eur. J. Med. Chem. 43: 917–924.10.1016/j.ejmech.2007.06.01117692433 Search in Google Scholar

Pagano M.A., M. Andrzejewska, M. Ruzzene, S. Sarno, L. Cesaro, J. Bain, M. Elliott, F. Meggio, Z. Kazimierczuk and others. 2004. Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole. J. Med .Chem. 47: 6239–6247. Search in Google Scholar

Pedini M., G. Alunni Bistocchi, A. Ricci, L. Bastianini and E. Lepri. 1994. New heterocyclic derivatives of benzimidazole with germicidal activity-XII--Synthesis of N1-glycosyl-2-furyl benzimidazoles. Farmaco 49: 823–827. Search in Google Scholar

Sharma S., S. Gangal and A. Rauf. 2009. Convenient one-pot synthesis of novel 2-substituted benzimidazoles, tetrahydrobenzimidazoles and imidazoles and evaluation of their in vitro antibacterial and antifungal activities. Eur. J. Med. Chem. 44: 1751–1757. Search in Google Scholar

Shingalapur R.V., K.M. Hosamani and R.S. Keri. 2009. Synthesis and evaluation of in vitro anti-microbial and anti-tubercular activity of 2-styryl benzimidazoles. Eur. J. Med. Chem. 44: 4244–4248.10.1016/j.ejmech.2009.05.02119540630 Search in Google Scholar

Tunçbilek M., T. Kiper and N. Altanlar. 2009. Synthesis and in vitro antimicrobial activity of some novel substituted benzimidazole derivatives having potent activity against MRSA. Eur. J. Med. Chem. 44: 1024–1033.10.1016/j.ejmech.2008.06.02618718694 Search in Google Scholar

Vinodkumar R., S.D. Vaidya, B.V. Siva Kumar, U.N. Bhise, S.B. Bhirud and U.C. Mashelkar. 2008. Synthesis, anti-bacterial, anti-asthmatic and anti-diabetic activities of novel N-substituted- 2-(4-phenylethynyl-phenyl)-1H-benzimidazoles and N-substituted 2[4-(4,4-dimethyl-thioc hroman-6-yl-ethynyl)-phenyl)-1H-benzi- midazoles. Eur. J. Med. Chem. 43: 986–995. Search in Google Scholar

Zacny V.L., E. Gershburg, M.G. Davis, K.K. Biron and J.S. Pagano. 1999. Inhibition of Epstein-Barr virus replication by a benzimidazole L-riboside: novel antiviral mechanism of 5, 6-dichloro- 2-(isopropylamino)-1-beta-L-ribofuranosyl-1H-benzimidazole. J. Virol. 73: 7271–7277. Search in Google Scholar