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Selenium and cancer or adenoma related to the large bowel*


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Fig. 1

Search strategy
Search strategy

Fig. 2

Food sources of selenium in diet and content of selenium in different products. 1 ounce = 28.35 g; 1 cup = 150 g
Food sources of selenium in diet and content of selenium in different products. 1 ounce = 28.35 g; 1 cup = 150 g

Fig. 3

Observational studies on CRC and selenium – an overview.1all-cause mortality among patients with nonmetastatic colorectal cancer2calculated from original paper: ≥7 servings of milk/week vs <1 serving of milk/week (1 serving of milk=1 cup of milk=200 g of milk; 100 g of milk = 2 µg Se358.89 µg/day – a cut off point of total selenium4OR (95% CI) – odds ratio and 95% confidence intervalCC – colon cancer; AP – adenomatous polyps; CA – colorectal adenoma.CC – colon cancer; AP – adenomatous polyps; CA – colorectal adenoma
Observational studies on CRC and selenium – an overview.1all-cause mortality among patients with nonmetastatic colorectal cancer2calculated from original paper: ≥7 servings of milk/week vs <1 serving of milk/week (1 serving of milk=1 cup of milk=200 g of milk; 100 g of milk = 2 µg Se358.89 µg/day – a cut off point of total selenium4OR (95% CI) – odds ratio and 95% confidence intervalCC – colon cancer; AP – adenomatous polyps; CA – colorectal adenoma.CC – colon cancer; AP – adenomatous polyps; CA – colorectal adenoma

Fig. 4

Experimental studies on CRC and selenium – an overview.*advanced colorectal adenoma characteristics: size ≥10 mm, villous component, high-grade dysplasia**odds ratio as in original paper***HR with 95% CI was calculated from the original HR 1.05 99% CI (0.66–1.67)1tablets: 200 µg Se with 30 mg zinc, 2 mg vitamin A, 180 mg vitamin C, 30 mg vitamin E2200 µg yeast tablets (191–201 µg selenium content)3coctail: 4 g calcium carbonate, 101 µg selenium (from 170 µg sodium selenite), 15 mg β-carotene, 75 mg α-tocopherol, 150 mg ascorbic acid4200 µg of Se supplied in a 0.5-g high selenium baker’s yeast tablet5200 µg Se/day from L-selenomethionine6hazard ratio/risk ratio and 95% confidence interval
Experimental studies on CRC and selenium – an overview.*advanced colorectal adenoma characteristics: size ≥10 mm, villous component, high-grade dysplasia**odds ratio as in original paper***HR with 95% CI was calculated from the original HR 1.05 99% CI (0.66–1.67)1tablets: 200 µg Se with 30 mg zinc, 2 mg vitamin A, 180 mg vitamin C, 30 mg vitamin E2200 µg yeast tablets (191–201 µg selenium content)3coctail: 4 g calcium carbonate, 101 µg selenium (from 170 µg sodium selenite), 15 mg β-carotene, 75 mg α-tocopherol, 150 mg ascorbic acid4200 µg of Se supplied in a 0.5-g high selenium baker’s yeast tablet5200 µg Se/day from L-selenomethionine6hazard ratio/risk ratio and 95% confidence interval

Daily seleniuim intake through different geographic regions

Geographic differences in a daily selenium intakes (µg/day)
Region Selenium intake (Mean ± standard error or range)
China, disease-free area 13.3± 3.1
China, Keshan disease area 3–11
China, seleniferous area 1338
South Sweden, conventional diets 40± 4
Finland, before selenium fertilization 26
Finland, after selenium in fertilization 56
Slovakia 27± 8
Poland 30–40
United Kingdom, 1974 60
United Kingdom, 1995 33
Italy 41
Germany 38–48
France 47
India, conventional diet 48
Canada 98–224
United States, all 80± 37
United States, seleniferous area 216
Venezuela 80–500

Quality of observational studies measured with a use of a Newcastle Ottawa Scale (NOS)

Observational studies Name of study Population Sample size Number of earned stars in a Newcastle Ottawa Scale (NOS)
Lener M. et al. 2013 [20] case-control no data available on cases recruitment; controls were selected from Polish and Estonian registers 338(169 colorectal cancer patients; 169 controls) 6
Connelly-Frost A. et al. 2009 [6] case-control cases from North Carolina cancer registry; population-based control (selected from 33-county area in central North Carolina) 1691(643 cases; 1048 controls) 5
Fernández-Bañares F. et al. 2002 [8] case-control hospital-based cases; controls belonging to a big survey performed in Spain were included in the study 87(52 cases; 35 controls) 6
Hughes D.J. et al. 2015 [14] nested case-control cases were identified during EPIC follow-up with a use of population cancer registries (Denmark, Italy, Netherlands, Spain, United Kingdom) and other methods: health insurance records, pathology registries, active contact of study subjects; controls were matched 1:1 by a study center, but no other data were available on the control’s recruitment 1932(966 cases; 966 controls) 7
Peters U. et al. 2006 [27] nested case-control cases and controls were randomly selected from 42 037 participants in the screening group of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial 1525(772 cases; 777 controls) 6
Wallace K. et al. 2003 [36] nested case-control cases and controls were recruited (including special criteria) from participants of the placebo-controlled trial (those have been chosen at six clinical centers in the U.S.) 552(276 cases; 276 controls) 5
Takata Y. et al. 2011 [31] nested case-control cases were recruited mostly with a use of mass mailing which were age-targeted and media announcements in areas surrounding the 40 WHI clinical centers across the U.S.; controls were selected from all eligible women in the WHI study who were alive and had not been diagnosed with CRC at the time of the case’s diagnosis; 1609(804 cases; 805 controls) 5
Ghadirian P. et al. 2000 [10] case-control mainly hospital-based cases, identified through the admission offices of 5 major teaching hospitals; population-based controls (modified random-digit dialing method) 1736(1048 cases, 688 controls) 4
Kune G., Watson L. 2006 [18] case-control cases from the etiological arm of population-based investigation; controls were randomly chosen from community, Melbourne, Australia 1442(715 cases; 727 controls) 5
Yang B. et al. 2014 [39] cohort participants from Cancer Prevention Study II Nutrition Cohort. II Nutrition Cohort was selected as a subgroup of larger CPS cohort in which approximately 1.2 million of people were enrolled by volunteers in all 50 states, the District of Columbia and Puerto Rico 2284 6
Williams C.D. et al. 2010 [38] nested case-control cases were chosen from the North Carolina Central Cancer Registry; controls <65 years were selected by using lists provided by the North Carolina Division of Motor Vehicles and the Center for Medicaid and Medicare Services for those 65 and older; controls were selected from subjects (African American or White) resided in one of 33 counties in central and eastern North Carolina. A randomized recruitment procedure was used for identifying cases and controls 2076(1057 cases; 1019 controls) 4
Hansen R.D. et al. 2013 [12] cohort population-based cohort, which based on 54 208 members of the Diet, Cancer and Health Cohort Study 54 208 5

Quality of intervention studies measured with a use of a Jadad Scale

Intervention studies Number of points in a Jadad Scale
Bonelli L. et al. 2013 [3] 3
Thompson P.A. et al. 2016 [32] 2
Hofstad B. et al. 1998 [13] 3
Duffield-Lillico A.J. et al. 2002 [7] 5
Lippman S.M. et al. 2009 [23] 4
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