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Comprehensive lifestyle modification as complementary therapy to prevent and manage post-transplant diabetes mellitus*


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Nutritional recommendations for patients with Chronic Kidney Disease (CKD) [30, 31]

CHRONIC KIDNEY DISEASE
Hemodialysis [HD] Peritoneal dialysis [PD]
Protein 1.2 g/kg [stage 5 CKD] 1.2–1.3 g/kg [stage 5 CKD]
Energy 30–35 kcal/kg/day 30–35 kcal/kg/day
Fat 30% kcal 30% kcal
Fluids Loss with urine + 500–1000 ml Loss with urine + 1000 ml
Electrolytes and minerals < 2.4 g sodium/day< 2.4 g potassium/day800–1000 mg phosphorus/day< 2000 mg calcium/day 2 g sodium/day3–4 g potassium/day800–1000 mg phosphorus/day< 2000 mg calcium/day
Vitamins 3 µg vitamin B12
1–5 mg/day folic acid
1.5–2mg/day vitamin B1

Risk factors for the development of post-transplant diabetes mellitus PTDM [15, 26, 27]

Modifiable risk factors PTDM Non-modifiable risk factors PTDM
Overweight (BMI > 25 kg/m2) or Obesity (BMI > 30 kg/m2) Positive family history of type 2 diabetes
Hepatitis C (HCV) Age at day of transplantation (> 40 years)
Cytomegalovirus infection (CMV) Ethnic origin (African-Americans, Hispanics)
Hypertension Polycyclic kidney disease – ADPKD
Immunosuppression HLA A26 or B27
Low physical activity Male gender
Smoking Peritoneal dialysis
Pre-diabetes conditions (impaired fasting glucose IFG and/or impaired)
Hypertriglyceridemia

Nutritional recommendations for kidney transplantation patients [30, 31]

POST-KIDNEY TRANSPLANTATION
ACUTE PHASE CHRONIC PHASE
Protein 1.2–2.0 g/kg 0.6–0.8 g/kg
Energy 30–35 kcal/kg 25–30 kcal/kg
Fat 30–50% low-fat products < 30% kcal< 300 mg cholesterol7–10% kcal from saturated fat
Carbohydrates 50–70% kcal 45–50% kcal
Electrolytes and minerals without saltmonitor: potassium, phosphorus, magnesium1000–1500 mg calcium/day
vitamin D supplementation
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