About this article
Article Category: Review
Published Online: Feb 04, 2021
Page range: 64 - 84
Received: Jan 08, 2020
Accepted: Sep 11, 2020
DOI: https://doi.org/10.5604/01.3001.0014.7145
Keywords
© 2021 Anna Szymanowska et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Ryc. 1
![Wzory strukturalne triazyn. A-[1,2,3]triazyny, B-[1,2,4]triazyny, C-[1,3,5]triazyny]”](https://sciendo-parsed.s3.eu-central-1.amazonaws.com/647088b271e4585e08a9f607/j_01.3001.0014.7145_fig_001.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20240722T121646Z&X-Amz-SignedHeaders=host&X-Amz-Expires=18000&X-Amz-Credential=AKIA6AP2G7AKP25APDM2%2F20240722%2Feu-central-1%2Fs3%2Faws4_request&X-Amz-Signature=c8e206b90b5ab68e98a20de0151fa15d819581c4f8392301fbdde669e9beaabb)
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![Wzór strukturalny najbardziej aktywnej pochodnej 3,7-diarylo-5-(3,4,5-trimetoksyfenylo)-pirazolo[4,3-e][1,2,4]triazyny – związku 3](https://sciendo-parsed.s3.eu-central-1.amazonaws.com/647088b271e4585e08a9f607/j_01.3001.0014.7145_fig_005.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20240722T121646Z&X-Amz-SignedHeaders=host&X-Amz-Expires=18000&X-Amz-Credential=AKIA6AP2G7AKP25APDM2%2F20240722%2Feu-central-1%2Fs3%2Faws4_request&X-Amz-Signature=96b784a407f382d232b47d559938a301cc6b95090baece741462dbf19c599b3f)
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![Wzór strukturalny pochodnych 1,5-diarylo-3-(3,4,5-trihydroksyfenylo)-1H-pirazolo[4,3-e][1,2,4]triazyny (4a-4i)](https://sciendo-parsed.s3.eu-central-1.amazonaws.com/647088b271e4585e08a9f607/j_01.3001.0014.7145_fig_007.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20240722T121646Z&X-Amz-SignedHeaders=host&X-Amz-Expires=17999&X-Amz-Credential=AKIA6AP2G7AKP25APDM2%2F20240722%2Feu-central-1%2Fs3%2Faws4_request&X-Amz-Signature=bfeb6a4b05962bdf0eea6f04c7a14e7572f0ca67f53967ac2e40678ade097670)
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![Wzory strukturalne sulfonamidowych pochodnych pirazolo[4,3-e][1,2,4]triazyny (9a-9j)](https://sciendo-parsed.s3.eu-central-1.amazonaws.com/647088b271e4585e08a9f607/j_01.3001.0014.7145_fig_009.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20240722T121646Z&X-Amz-SignedHeaders=host&X-Amz-Expires=18000&X-Amz-Credential=AKIA6AP2G7AKP25APDM2%2F20240722%2Feu-central-1%2Fs3%2Faws4_request&X-Amz-Signature=f08881d202a588c6df57328f76f8d77f865e3942a03071d9a1401b6a0ef844f5)
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![Wzór strukturalny związku (3-(4-(2-(dietyloamino)etoksy)fenylo)-1,6-dimetylopirymido[5,4-e]-1,2,4]triazyn-7,7(1H,6H)dion](https://sciendo-parsed.s3.eu-central-1.amazonaws.com/647088b271e4585e08a9f607/j_01.3001.0014.7145_fig_012.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20240722T121646Z&X-Amz-SignedHeaders=host&X-Amz-Expires=18000&X-Amz-Credential=AKIA6AP2G7AKP25APDM2%2F20240722%2Feu-central-1%2Fs3%2Faws4_request&X-Amz-Signature=7381d3cb165eae61388982f9a1f8421cbcc2e0299564085b2eaa2e2b0f544f1f)
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![Wzory strukturalne pochodnych benzo[1,2,4]triazyn-7-onów](https://sciendo-parsed.s3.eu-central-1.amazonaws.com/647088b271e4585e08a9f607/j_01.3001.0014.7145_fig_015.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20240722T121646Z&X-Amz-SignedHeaders=host&X-Amz-Expires=18000&X-Amz-Credential=AKIA6AP2G7AKP25APDM2%2F20240722%2Feu-central-1%2Fs3%2Faws4_request&X-Amz-Signature=41fdaa0c49539460c6e03e3746b3772bbc3dab89c883e7ecab1197befab9ad00)
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![Wzory strukturalne pochodnych 6-winylo-[1,2,4]triazyn-5-onów](https://sciendo-parsed.s3.eu-central-1.amazonaws.com/647088b271e4585e08a9f607/j_01.3001.0014.7145_fig_020.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20240722T121646Z&X-Amz-SignedHeaders=host&X-Amz-Expires=18000&X-Amz-Credential=AKIA6AP2G7AKP25APDM2%2F20240722%2Feu-central-1%2Fs3%2Faws4_request&X-Amz-Signature=1170da64e95d29f7a891a8cea4a4b57e5fc80c4f8f9a5968e6146b313bf588ec)
Ryc. 21
![Wzory strukturalne pochodnych benzo[1,2,4]triazyn-7-onów](https://sciendo-parsed.s3.eu-central-1.amazonaws.com/647088b271e4585e08a9f607/j_01.3001.0014.7145_fig_021.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20240722T121646Z&X-Amz-SignedHeaders=host&X-Amz-Expires=18000&X-Amz-Credential=AKIA6AP2G7AKP25APDM2%2F20240722%2Feu-central-1%2Fs3%2Faws4_request&X-Amz-Signature=d8fcff058ba03f43bd88efb5cb59b2b7355ab805d526622914c4535520a7ba63)
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![Wzory strukturalne nowo zsyntetyzowanych fluorowych pochodnych [1,2,4]triazynonów](https://sciendo-parsed.s3.eu-central-1.amazonaws.com/647088b271e4585e08a9f607/j_01.3001.0014.7145_fig_023.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20240722T121646Z&X-Amz-SignedHeaders=host&X-Amz-Expires=18000&X-Amz-Credential=AKIA6AP2G7AKP25APDM2%2F20240722%2Feu-central-1%2Fs3%2Faws4_request&X-Amz-Signature=6abb4ed9122f5b670e380112089fa9f98384b613823f69fe81176176be25ec9b)
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![Wzory strukturalne C-nukleozydowych pochodnych zawierające układ pirolo[2,1-f][1,2,4]triazyno-4-aminowy](https://sciendo-parsed.s3.eu-central-1.amazonaws.com/647088b271e4585e08a9f607/j_01.3001.0014.7145_fig_027.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20240722T121646Z&X-Amz-SignedHeaders=host&X-Amz-Expires=18000&X-Amz-Credential=AKIA6AP2G7AKP25APDM2%2F20240722%2Feu-central-1%2Fs3%2Faws4_request&X-Amz-Signature=669ac7fe9093e993fbbecddc3841512746bd4de1899a372105391bfbc5fd9d71)
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![Pochodne pirydazyno[3′,4′:5,6][1,2,4]triazyno[3,4-b][1,3,4]tiadiazyny](https://sciendo-parsed.s3.eu-central-1.amazonaws.com/647088b271e4585e08a9f607/j_01.3001.0014.7145_fig_030.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20240722T121646Z&X-Amz-SignedHeaders=host&X-Amz-Expires=18000&X-Amz-Credential=AKIA6AP2G7AKP25APDM2%2F20240722%2Feu-central-1%2Fs3%2Faws4_request&X-Amz-Signature=688b85f9b3e99adc2ea312cf3d725db2b459fe4738adf60b3881c7fc36d917e4)
Ryc. 31
![Wzory strukturalne pochodnych układu 3-(2-arylidenehydrazynylo)-5,6-bis(4-metoksyfenylo)[1,2,4]triazyny](https://sciendo-parsed.s3.eu-central-1.amazonaws.com/647088b271e4585e08a9f607/j_01.3001.0014.7145_fig_031.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20240722T121646Z&X-Amz-SignedHeaders=host&X-Amz-Expires=18000&X-Amz-Credential=AKIA6AP2G7AKP25APDM2%2F20240722%2Feu-central-1%2Fs3%2Faws4_request&X-Amz-Signature=b713bcca0096db7af1260934ab9ad479e3545aefce751811e9dd14ff304c0ea6)
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Wzory strukturalne najbardziej aktywnych pochodnych
| 28 | a | O | |
| b | S | ||
Wzory strukturalne nowych pochodnych benzo[e][1,2,4]triazyno[2,3-c][1,2,3]triazyn-2-onów
| R1 | R2 | R3 | ||
| a | CH3 | H | H | |
| b | C6H5 | H | H | |
| c | 4-CH3-C6H4 | H | H | |
| d | 4-iPr-C6H4 | H | H | |
| e | 4-tBu-C6H4 | H | H | |
| f | 4-OCH3-C6H4 | H | H | |
| g | 4-F-C6H4 | H | H | |
| h | C6H5 | CH3 | H | |
| i | C6H5 | H | Br | |
| j | 4-F-C6H4 | H | Br | |
Nazwy grup funkcyjnych R1 i R2
| 4a | fenylowa | 2-hydroksyfenylowa |
| 4b | fenylowa | 3-hydroksyfenylowa |
| 4c | fenylowa | 4-hydroksyfenylowa |
| 4d | 4-chlorofenylowa | 2-hydroksyfenylowa |
| 4e | 4-chlorofenylowa | 3-hydroksyfenylowa |
| 4f | 4-chlorofenylowa | 4-hydroksyfenylowa |
| 4g | 4-chlorofenylowa | 4-chlorofenylowa |
| 4h | 4-chlorofenylowa | 3,4,5-trihydroksyfenylowa |
| 4i | 3,4,5-trihydroksyfenylowa | 3,4,5-trihydroksyfenylowa |
Wzory strukturalne podstawników
| a | b | c | d | e | f | |
| R= | - | - | ||||
| R1= | -H | -OH | -OCH3 | -Cl | -Br | -NO2 |
Wzór ogólny disulfonowych pochodnych układu [1,2,4]triazyny i nazwy podstawników R we wzorze 15
| a: R= izopropylowa | h: R= fenylowa | |
| b: R= n-butylowa | i: R= p-toluenowa | |
| c: R= tert-butylowa | j: R= 4-metoksyfenylowa | |
| d: R= izobutylowa | k: R= 4-chlorofenylowa | |
| e: R= n-pentylowa | l: R= 4-nitrofenylowa | |
| f: R= dodecylowa | m: R= 2,4-dinitrofenylowa | |
| g: R=1-hydroksyundecylowa | n: R= 2-benzotiazolowa |
Wzory strukturalne pochodnych pirazolo[4,3-e]triazolo[4,5-b] [1,2,4]triazyny
| a | -H | |
| b | -CH3 | |
| c | -CH2Cl | |