The role of miRNA in selected tumors development: Potential use in diagnostics

[1] Amr K.S., Ezzat W.M., Elhosary Y.A., Hegazy A.E., Fahim H.H., Kamel R.R.: The potential role of miRNAs 21 and 199-a in early diagnosis of hepatocellular carcinoma. Gene, 2016; 575: 66–70 AmrK.S. EzzatW.M. ElhosaryY.A. HegazyA.E. FahimH.H. KamelR.R. The potential role of miRNAs 21 and 199-a in early diagnosis of hepatocellular carcinoma Gene 2016 575 66 70 10.1016/j.gene.2015.08.03826302751 Search in Google Scholar

[2] Anfossi S., Giordano A., Gao H., Cohen E.N., Tin S., Wu Q., Garza R.J., Debeb B.G., Alvarez R.H., Valero V., Hortobagyi G.N., Calin G.A., Ueno N.T., Woodward W.A., Reuben J.M.: High serum miR-19a levels are associated with inflammatory breast cancer and are predictive of favorable clinical outcome in patients with metastatic HER2+ inflammatory breast cancer. PLoS One, 2014; 9: e83113 AnfossiS. GiordanoA. GaoH. CohenE.N. TinS. WuQ. GarzaR.J. DebebB.G. AlvarezR.H. ValeroV. HortobagyiG.N. CalinG.A. UenoN.T. WoodwardW.A. ReubenJ.M. High serum miR-19a levels are associated with inflammatory breast cancer and are predictive of favorable clinical outcome in patients with metastatic HER2+ inflammatory breast cancer PLoS One 2014 9 e83113 10.1371/journal.pone.0083113388540524416156 Search in Google Scholar

[3] Antolin S., Calvo L., Blanco-Calvo M., Santiago M.P., Lorenzo-Patiño M.J., Haz-Conde M., Santamarina I., Figueroa A., Antón-Aparicio L.M., Valladares-Ayerbes M.: Circulating miR-200c and miR-141 and outcomes in patients with breast cancer. BMC Cancer, 2015; 15: 297 AntolinS. CalvoL. Blanco-CalvoM. SantiagoM.P. Lorenzo-PatiñoM.J. Haz-CondeM. SantamarinaI. FigueroaA. Antón-AparicioL.M. Valladares-AyerbesM. Circulating miR-200c and miR-141 and outcomes in patients with breast cancer BMC Cancer 2015 15 297 10.1186/s12885-015-1238-5440584325885099 Search in Google Scholar

[4] Asaga S., Kuo C., Nguyen T., Terpenning M., Giuliano A.E., Hoon D.S.: Direct serum assay for microRNA-21 concentrations in early and advanced breast cancer. Clin. Chem., 2011; 57: 84–91 AsagaS. KuoC. NguyenT. TerpenningM. GiulianoA.E. HoonD.S. Direct serum assay for microRNA-21 concentrations in early and advanced breast cancer Clin. Chem. 2011 57 84 91 10.1373/clinchem.2010.15184521036945 Search in Google Scholar

[5] Basati G., Emami Razavi A., Abdi S., Mirzaei A.: Elevated level of microRNA-21 in the serum of patients with colorectal cancer. Med. Oncol., 2014; 31: 205 BasatiG. Emami RazaviA. AbdiS. MirzaeiA. Elevated level of microRNA-21 in the serum of patients with colorectal cancer Med. Oncol. 2014 31 205 10.1007/s12032-014-0205-325178939 Search in Google Scholar

[6] Basati G., Razavi A.E., Pakzad I., Malayeri F.A.: Circulating levels of the miRNAs, miR-194, and miR-29b, as clinically useful biomarkers for colorectal cancer. Tumour Biol., 2016; 37: 1781–1788 BasatiG. RazaviA.E. PakzadI. MalayeriF.A. Circulating levels of the miRNAs, miR-194, and miR-29b, as clinically useful biomarkers for colorectal cancer Tumour Biol. 2016 37 1781 1788 10.1007/s13277-015-3967-026318304 Search in Google Scholar

[7] Beckett E.L., Martin C., Choi J.H., King K., Niblett S., Boyd L., Duesing K., Yates Z., Veysey M., Lucock M.: Folate status, folate-related genes and serum miR-21 expression: Implications for miR-21 as a biomarker. BBA Clin., 2015; 4: 45–51 BeckettE.L. MartinC. ChoiJ.H. KingK. NiblettS. BoydL. DuesingK. YatesZ. VeyseyM. LucockM. Folate status, folate-related genes and serum miR-21 expression: Implications for miR-21 as a biomarker BBA Clin. 2015 4 45 51 10.1016/j.bbacli.2015.06.006466171326674922 Search in Google Scholar

[8] Branch A.D., Rice C.M.: Antisense gets a grip on miR-122 in chimpanzees. Sci. Transl. Med., 2010; 2: 13ps1 BranchA.D. RiceC.M. Antisense gets a grip on miR-122 in chimpanzees Sci. Transl. Med. 2010 2 13ps1 10.1126/scitranslmed.300060520371461 Search in Google Scholar

[9] Cazzoli R., Buttitta F., Di Nicola M., Malatesta S., Marchetti A., Rom W.N., Pass H.I.: microRNAs derived from circulating exosomes as noninvasive biomarkers for screening and diagnosing lung cancer. J. Thorac. Oncol., 2013; 8: 1156–1162 CazzoliR. ButtittaF. Di NicolaM. MalatestaS. MarchettiA. RomW.N. PassH.I. microRNAs derived from circulating exosomes as noninvasive biomarkers for screening and diagnosing lung cancer J. Thorac. Oncol. 2013 8 1156 1162 10.1097/JTO.0b013e318299ac32412322223945385 Search in Google Scholar

[10] Chen L., Heikkinen L., Wang C., Yang Y., Sun H., Wong G.: Trends in the development of miRNA bioinformatics tools. Brief. Bioinform., 2019; 20: 1836–1852 ChenL. HeikkinenL. WangC. YangY. SunH. WongG. Trends in the development of miRNA bioinformatics tools Brief. Bioinform. 2019 20 1836 1852 10.1093/bib/bby054741452429982332 Search in Google Scholar

[11] Chen W.Y., Zhao X.J., Yu Z.F., Hu F.L., Liu Y.P., Cui B.B., Dong X.S., Zhao Y.S.: The potential of plasma miRNAs for diagnosis and risk estimation of colorectal cancer. Int. J. Clin. Exp. Pathol., 2015; 8: 7092–7101 ChenW.Y. ZhaoX.J. YuZ.F. HuF.L. LiuY.P. CuiB.B. DongX.S. ZhaoY.S. The potential of plasma miRNAs for diagnosis and risk estimation of colorectal cancer Int. J. Clin. Exp. Pathol. 2015 8 7092 7101 Search in Google Scholar

[12] Chen Y., Du M., Wang J., Xing P., Zhang Y., Li F., Lu X.: MiRNA-200a expression is inverse correlation with hepatocyte growth factor expression in stromal fibroblasts and its high expression predicts a good prognosis in patients with non-small cell lung cancer. Onco-target, 2016; 7: 48432–48442 ChenY. DuM. WangJ. XingP. ZhangY. LiF. LuX. MiRNA-200a expression is inverse correlation with hepatocyte growth factor expression in stromal fibroblasts and its high expression predicts a good prognosis in patients with non-small cell lung cancer Onco-target 2016 7 48432 48442 10.18632/oncotarget.10302521702927374174 Search in Google Scholar

[13] Conev N.V., Donev I.S., Konsoulova-Kirova A.A., Chervenkov T.G., Kashlov J.K., Ivanov K.D.: Serum expression levels of miR-17, miR-21, and miR-92 as potential biomarkers for recurrence after adjuvant chemotherapy in colon cancer patients. BioSci. Trends, 2015; 9: 393–401 ConevN.V. DonevI.S. Konsoulova-KirovaA.A. ChervenkovT.G. KashlovJ.K. IvanovK.D. Serum expression levels of miR-17, miR-21, and miR-92 as potential biomarkers for recurrence after adjuvant chemotherapy in colon cancer patients BioSci. Trends 2015 9 393 401 10.5582/bst.2015.0117026781797 Search in Google Scholar

[14] Cui E.H., Li H.J., Hua F., Wang B., Mao W., Feng X.R., Li J.Y., Wang X.: Serum microRNA 125b as a diagnostic or prognostic biomarker for advanced NSCLC patients receiving cisplatin-based chemotherapy. Acta Pharmacol. Sin., 2013; 34: 309–313 CuiE.H. LiH.J. HuaF. WangB. MaoW. FengX.R. LiJ.Y. WangX. Serum microRNA 125b as a diagnostic or prognostic biomarker for advanced NSCLC patients receiving cisplatin-based chemotherapy Acta Pharmacol. Sin. 2013 34 309 313 10.1038/aps.2012.125401161822983388 Search in Google Scholar

[15] Del Vescovo V., Grasso M., Barbareschi M., Denti M.A.: MicroRNAs as lung cancer biomarkers. World J. Clin. Oncol., 2014; 54: 604–620 Del VescovoV. GrassoM. BarbareschiM. DentiM.A. MicroRNAs as lung cancer biomarkers World J. Clin. Oncol. 2014 54 604 620 10.5306/wjco.v5.i4.604412952625302165 Search in Google Scholar

[16] Dou H., Wang Y., Su G., Zhao S.: Decreased plasma let-7c and miR-152 as noninvasive biomarker for non-small-cell lung cancer. Int. J. Clin. Exp. Med., 2015; 8: 9291–9298 DouH. WangY. SuG. ZhaoS. Decreased plasma let-7c and miR-152 as noninvasive biomarker for non-small-cell lung cancer Int. J. Clin. Exp. Med. 2015 8 9291 9298 Search in Google Scholar

[17] Ebrahimi A., Sadroddiny E.: MicroRNAs in lung diseases: Recent findings and their pathophysiological implications. Pulm. Pharmacol. Ther., 2015; 34: 55–63 EbrahimiA. SadroddinyE. MicroRNAs in lung diseases: Recent findings and their pathophysiological implications Pulm. Pharmacol. Ther. 2015 34 55 63 10.1016/j.pupt.2015.08.00726319446 Search in Google Scholar

[18] Eichelser C., Flesch-Janys D., Chang-Claude J., Pantel K., Schwarzenbach H.: Deregulated serum concentrations of circulating cell-free microRNAs miR-17, miR-34a, miR-155, and miR-373 in human breast cancer development and progression. Clin. Chem., 2013; 59: 1489–1496 EichelserC. Flesch-JanysD. Chang-ClaudeJ. PantelK. SchwarzenbachH. Deregulated serum concentrations of circulating cell-free microRNAs miR-17, miR-34a, miR-155, and miR-373 in human breast cancer development and progression Clin. Chem. 2013 59 1489 1496 10.1373/clinchem.2013.20516123748853 Search in Google Scholar

[19] Erbes T., Hirschfeld M., Rücker G., Jaeger M., Boas J., Iborra S., Mayer S., Gitsch G., Stickeler E.: Feasibility of urinary microRNA detection in breast cancer patients and its potential as an innovative non-invasive biomarker. BMC Cancer, 2015; 15: 193 ErbesT. HirschfeldM. RückerG. JaegerM. BoasJ. IborraS. MayerS. GitschG. StickelerE. Feasibility of urinary microRNA detection in breast cancer patients and its potential as an innovative non-invasive biomarker BMC Cancer 2015 15 193 10.1186/s12885-015-1190-4438306625886191 Search in Google Scholar

[20] Eyking A., Reis H., Frank M., Gerken G., Schmid K.W., Cario E.: MiR-205 and MiR-373 are associated with aggressive human mucinous colorectal cancer. PLoS One, 2016; 11: e0156871 EykingA. ReisH. FrankM. GerkenG. SchmidK.W. CarioE. MiR-205 and MiR-373 are associated with aggressive human mucinous colorectal cancer PLoS One 2016 11 e0156871 10.1371/journal.pone.0156871489464227271572 Search in Google Scholar

[21] Feng C., Xian Q., Liu S.: Micro RNA-518 inhibits gastric cancer cell growth by inducing apoptosis via targeting MDM2. Biomed. Pharmacother., 2018; 97: 1595–1602 FengC. XianQ. LiuS. Micro RNA-518 inhibits gastric cancer cell growth by inducing apoptosis via targeting MDM2 Biomed. Pharmacother. 2018 97 1595 1602 10.1016/j.biopha.2017.11.09129793321 Search in Google Scholar

[22] Ferro A., Peleteiro B., Malvezzi M., Bosetti C., Bertuccio P., Levi F., Negri E., La Vecchia C., Lunet N.: Worldwide trends in gastric cancer mortality (1980–2011), with predictions to 2015, and incidence by subtype. Eur. J. Cancer, 2014; 50: 1330–1344 FerroA. PeleteiroB. MalvezziM. BosettiC. BertuccioP. LeviF. NegriE. La VecchiaC. LunetN. Worldwide trends in gastric cancer mortality (1980–2011), with predictions to 2015, and incidence by subtype Eur. J. Cancer 2014 50 1330 1344 10.1016/j.ejca.2014.01.02924650579 Search in Google Scholar

[23] Fire A., Xu S., Montgomery M.K., Kostas S.A., Driver S.E., Mello C.C.: Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature, 1998; 391: 806–811 FireA. XuS. MontgomeryM.K. KostasS.A. DriverS.E. MelloC.C. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans Nature 1998 391 806 811 10.1038/358889486653 Search in Google Scholar

[24] Gao F., Chang J., Wang H., Zhang G.: Potential diagnostic value of miR-155 in serum from lung adenocarcinoma patients. Oncol. Rep., 2014; 31: 351–357 GaoF. ChangJ. WangH. ZhangG. Potential diagnostic value of miR-155 in serum from lung adenocarcinoma patients Oncol. Rep. 2014 31 351 357 10.3892/or.2013.283024190459 Search in Google Scholar

[25] Ge W., Yu D.C., Li Q.G., Chen X., Zhang C.Y., Ding Y.T.: Expression of serum miR-16, let-7f, and miR-21 in patients with hepato-cellular carcinoma and their clinical significances. Clin. Lab., 2014; 60: 427–434 GeW. YuD.C. LiQ.G. ChenX. ZhangC.Y. DingY.T. Expression of serum miR-16, let-7f, and miR-21 in patients with hepato-cellular carcinoma and their clinical significances Clin. Lab. 2014 60 427 434 Search in Google Scholar

[26] Geng Q., Fan T., Zhang B., Wang W., Xu Y., Hu H.: Five microRNAs in plasma as novel biomarkers for screening of early-stage non-small cell lung cancer. Respir. Res., 2014; 15: 149 GengQ. FanT. ZhangB. WangW. XuY. HuH. Five microRNAs in plasma as novel biomarkers for screening of early-stage non-small cell lung cancer Respir. Res. 2014 15 149 10.1186/s12931-014-0149-3424844525421010 Search in Google Scholar

[27] Ghanbari R., Mosakhani N., Sarhadi V.K., Armengol G., Nouraee N., Mohammadkhani A., Khorrami S., Arefian E., Paryan M., Malekzadeh R., Knuutila S.: Simultaneous underexpression of let-7a-5p and let-7f-5p microRNAs in plasma and stool samples from early stage colorectal carcinoma. Biomark. Cancer, 2015; 7: 39–48 GhanbariR. MosakhaniN. SarhadiV.K. ArmengolG. NouraeeN. MohammadkhaniA. KhorramiS. ArefianE. ParyanM. MalekzadehR. KnuutilaS. Simultaneous underexpression of let-7a-5p and let-7f-5p microRNAs in plasma and stool samples from early stage colorectal carcinoma Biomark. Cancer 2015 7 39 48 10.4137/BIC.S25252471139126793011 Search in Google Scholar

[28] Hale M.D., Hayden J.D., Grabsch H.I.: Tumour-microenvironment interactions: Role of tumour stroma and proteins produced by cancer-associated fibroblasts in chemotherapy response. Cell Oncol., 2013; 36: 95–112 HaleM.D. HaydenJ.D. GrabschH.I. Tumour-microenvironment interactions: Role of tumour stroma and proteins produced by cancer-associated fibroblasts in chemotherapy response Cell Oncol. 2013 36 95 112 10.1007/s13402-013-0127-723494412 Search in Google Scholar

[29] Hanahan D., Weinberg R.A.: Hallmarks of cancer: The next generation, Cell, 2011; 144: 646–674 HanahanD. WeinbergR.A. Hallmarks of cancer: The next generation Cell 2011 144 646 674 10.1016/j.cell.2011.02.01321376230 Search in Google Scholar

[30] Haseeb A., Makki M.S., Khan N.M., Ahmad I., Haqqi T.M.: Deep sequencing and analyses of miRNAs, isomiRs and miRNA induced silencing complex (miRISC)-associated miRNome in primary human chondrocytes. Sci. Rep., 2017; 7: 15178 HaseebA. MakkiM.S. KhanN.M. AhmadI. HaqqiT.M. Deep sequencing and analyses of miRNAs, isomiRs and miRNA induced silencing complex (miRISC)-associated miRNome in primary human chondrocytes Sci. Rep. 2017 7 15178 10.1038/s41598-017-15388-4568023829123165 Search in Google Scholar

[31] Hayes C.N., Chayama K.: MicroRNAs as biomarkers for liver disease and hepatocellular carcinoma. Int. J. Mol. Sci., 2016; 17: 280 HayesC.N. ChayamaK. MicroRNAs as biomarkers for liver disease and hepatocellular carcinoma Int. J. Mol. Sci. 2016 17 280 10.3390/ijms17030280481314426927063 Search in Google Scholar

[32] Heegaard N.H., Schetter A.J., Welsh J.A., Yoneda M., Bowman E.D., Harris C.C.: Circulating micro-RNA expression profiles in early stage nonsmall cell lung cancer. Int. J. Cancer, 2012; 130: 1378–1386 HeegaardN.H. SchetterA.J. WelshJ.A. YonedaM. BowmanE.D. HarrisC.C. Circulating micro-RNA expression profiles in early stage nonsmall cell lung cancer Int. J. Cancer 2012 130 1378 1386 10.1002/ijc.26153325925821544802 Search in Google Scholar

[33] Higuchi T., Todaka H., Sugiyama Y., Ono M., Tamaki N., Hatano E., Takezaki Y., Hanazaki K., Miwa T., Lai S., Morisawa K., Tsuda M., Taniguchi T., Sakamoto S.: Suppression of microRNA-7 (miR-7) bio-genesis by nuclear factor 90-nuclear factor 45 complex (NF90-NF45) controls cell proliferation in hepatocellular carcinoma. J. Biol. Chem., 2016; 291: 21074–21084 HiguchiT. TodakaH. SugiyamaY. OnoM. TamakiN. HatanoE. TakezakiY. HanazakiK. MiwaT. LaiS. MorisawaK. TsudaM. TaniguchiT. SakamotoS. Suppression of microRNA-7 (miR-7) bio-genesis by nuclear factor 90-nuclear factor 45 complex (NF90-NF45) controls cell proliferation in hepatocellular carcinoma J. Biol. Chem. 2016 291 21074 21084 10.1074/jbc.M116.748210507651727519414 Search in Google Scholar

[34] Hu Z., Chen X., Zhao Y., Tian T., Jin G., Shu Y., Chen Y., Xu L., Zen K., Zhang C., Shen H.: Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer. J. Clin. Oncol., 2010; 28: 1721–1726 HuZ. ChenX. ZhaoY. TianT. JinG. ShuY. ChenY. XuL. ZenK. ZhangC. ShenH. Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer J. Clin. Oncol. 2010 28 1721 1726 10.1200/JCO.2009.24.934220194856 Search in Google Scholar

[35] Hu Z., Dong J., Wang L.E., Ma H., Liu J., Zhao Y., Tang J., Chen X., Dai J., Wei Q., Zhang C., Shen H.: Serum microRNA profiling and breast cancer risk: The use of miR-484/191 as endogenous controls. Carcinogenesis, 2012; 33: 828–834 HuZ. DongJ. WangL.E. MaH. LiuJ. ZhaoY. TangJ. ChenX. DaiJ. WeiQ. ZhangC. ShenH. Serum microRNA profiling and breast cancer risk: The use of miR-484/191 as endogenous controls Carcinogenesis 2012 33 828 834 10.1093/carcin/bgs03022298638 Search in Google Scholar

[36] Huang J., Wu J., Li Y., Li X., Yang T., Yang Q., Jiang Y.: Deregulation of serum microRNA expression is associated with cigarette smoking and lung cancer. Biomed. Res. Int., 2014; 2014: 364316 HuangJ. WuJ. LiY. LiX. YangT. YangQ. JiangY. Deregulation of serum microRNA expression is associated with cigarette smoking and lung cancer Biomed. Res. Int. 2014 2014 364316 10.1155/2014/364316421734725386559 Search in Google Scholar

[37] Huang Z., Huang D., Ni S., Peng Z., Sheng W., Du X.: Plasma micro-RNAs are promising novel biomarkers for early detection of colorectal cancer. Int. J. Cancer, 2010; 127: 118–126 HuangZ. HuangD. NiS. PengZ. ShengW. DuX. Plasma micro-RNAs are promising novel biomarkers for early detection of colorectal cancer Int. J. Cancer 2010 127 118 126 10.1002/ijc.2500719876917 Search in Google Scholar

[38] Janevska D., Chaloska-Ivanova V., Janevski V.: Hepatocellular carcinoma: Risk factors, diagnosis and treatment. Open Access Maced. J. Med. Sci., 2015; 3: 732–736 JanevskaD. Chaloska-IvanovaV. JanevskiV. Hepatocellular carcinoma: Risk factors, diagnosis and treatment Open Access Maced. J. Med. Sci. 2015 3 732 736 10.3889/oamjms.2015.111487791827275318 Search in Google Scholar

[39] Jiang L., Li X., Cheng Q., Zhang B.H.: Plasma microRNA might as a potential biomarker for hepatocellular carcinoma and chronic liver disease screening. Tumour Biol., 2015; 36: 7167–7174 JiangL. LiX. ChengQ. ZhangB.H. Plasma microRNA might as a potential biomarker for hepatocellular carcinoma and chronic liver disease screening Tumour Biol. 2015 36 7167 7174 10.1007/s13277-015-3446-725894380 Search in Google Scholar

[40] Jung E.J., Santarpia L., Kim J., Esteva F.J., Moretti E., Buzdar A.U., Di Leo A., Le X.F., Bast R.C., Jr., Park S.T., Pusztai L., Calin G.A.: Plasma microRNA 210 levels correlate with sensitivity to trastuzumab and tumor presence in breast cancer patients. Cancer, 2012; 118: 2603–2614 JungE.J. SantarpiaL. KimJ. EstevaF.J. MorettiE. BuzdarA.U. Di LeoA. LeX.F. BastR.C.Jr. ParkS.T. PusztaiL. CalinG.A. Plasma microRNA 210 levels correlate with sensitivity to trastuzumab and tumor presence in breast cancer patients Cancer 2012 118 2603 2614 10.1002/cncr.26565386401922370716 Search in Google Scholar

[41] Kim J.O., Gazala S., Razzak R., Guo L., Ghosh S., Roa W.H., Bédard E.L.: Non-small cell lung cancer detection using microRNA expression profiling of bronchoalveolar lavage fluid and sputum. Anticancer Res., 2015; 35: 1873–1880 KimJ.O. GazalaS. RazzakR. GuoL. GhoshS. RoaW.H. BédardE.L. Non-small cell lung cancer detection using microRNA expression profiling of bronchoalveolar lavage fluid and sputum Anticancer Res. 2015 35 1873 1880 Search in Google Scholar

[42] Kim S.Y., Jeon T.Y., Choi C.I., Kim D.H., Kim D.H., Kim G.H., Ryu D.Y., Lee B.E., Kim H.H.: Validation of circulating miRNA biomarkers for predicting lymph node metastasis in gastric cancer. J. Mol. Diagn, 2013; 15: 661–669 KimS.Y. JeonT.Y. ChoiC.I. KimD.H. KimD.H. KimG.H. RyuD.Y. LeeB.E. KimH.H. Validation of circulating miRNA biomarkers for predicting lymph node metastasis in gastric cancer J. Mol. Diagn 2013 15 661 669 10.1016/j.jmoldx.2013.04.00423806809 Search in Google Scholar

[43] Kodahl A.R., Lyng M.B., Binder H., Cold S., Gravgaard K., Knoop A.S., Ditzel H.J.: Novel circulating microRNA signature as a potential non-invasive multi-marker test in ER-positive early-stage breast cancer: A case control study. Mol. Oncol., 2014; 8: 874–883 KodahlA.R. LyngM.B. BinderH. ColdS. GravgaardK. KnoopA.S. DitzelH.J. Novel circulating microRNA signature as a potential non-invasive multi-marker test in ER-positive early-stage breast cancer: A case control study Mol. Oncol. 2014 8 874 883 10.1016/j.molonc.2014.03.002552852924694649 Search in Google Scholar

[44] Koga Y., Yamazaki N., Yamamoto Y., Yamamoto S., Saito N., Kakugawa Y., Otake Y., Matsumoto M., Matsumura Y.: Fecal miR-106a is a useful marker for colorectal cancer patients with false-negative results in immunochemical fecal occult blood test. Cancer Epidemiol. Biomarkers Prev., 2013; 22: 1844–1852 KogaY. YamazakiN. YamamotoY. YamamotoS. SaitoN. KakugawaY. OtakeY. MatsumotoM. MatsumuraY. Fecal miR-106a is a useful marker for colorectal cancer patients with false-negative results in immunochemical fecal occult blood test Cancer Epidemiol. Biomarkers Prev. 2013 22 1844 1852 10.1158/1055-9965.EPI-13-051223950216 Search in Google Scholar

[45] Kogo R., Mimori K., Tanaka F., Komune S., Mori M.: Clinical significance of miR-146a in gastric cancer cases. Clin. Cancer Res., 2011; 17: 4277–4284 KogoR. MimoriK. TanakaF. KomuneS. MoriM. Clinical significance of miR-146a in gastric cancer cases Clin. Cancer Res. 2011 17 4277 4284 10.1158/1078-0432.CCR-10-286621632853 Search in Google Scholar

[46] Kumar S., Keerthana R., Pazhanimuthu A., Perumal P.: Over-expression of circulating miRNA-21 and miRNA-146a in plasma samples of breast cancer patients. Indian J. Biochem. Biophys., 2013; 50: 210–214 KumarS. KeerthanaR. PazhanimuthuA. PerumalP. Over-expression of circulating miRNA-21 and miRNA-146a in plasma samples of breast cancer patients Indian J. Biochem. Biophys. 2013 50 210 214 Search in Google Scholar

[47] Larrea E., Sole C., Manterola L., Goicoechea I., Armesto M., Arestin M., Caffarel M.M., Araujo A.M., Araiz M., Fernandez-Mercado M., Lawrie C.H.: New concepts in cancer biomarkers: Circulating miRNAs in liquid biopsies. Int. J. Mol. Sci, 2016; 17: 627 LarreaE. SoleC. ManterolaL. GoicoecheaI. ArmestoM. ArestinM. CaffarelM.M. AraujoA.M. AraizM. Fernandez-MercadoM. LawrieC.H. New concepts in cancer biomarkers: Circulating miRNAs in liquid biopsies Int. J. Mol. Sci 2016 17 627 10.3390/ijms17050627488145327128908 Search in Google Scholar

[48] Le H.B., Zhu W.Y., Chen D.D., He J.Y., Huang Y.Y., Liu X.G., Zhang Y.K.: Evaluation of dynamic change of serum miR-21 and miR-24 in pre- and post-operative lung carcinoma patients. Med. Oncol., 2012; 29: 3190–3197 LeH.B. ZhuW.Y. ChenD.D. HeJ.Y. HuangY.Y. LiuX.G. ZhangY.K. Evaluation of dynamic change of serum miR-21 and miR-24 in pre- and post-operative lung carcinoma patients Med. Oncol. 2012 29 3190 3197 10.1007/s12032-012-0303-z22782668 Search in Google Scholar

[49] Li J., Liu Y., Wang C., Deng T., Liang H., Wang Y., Huang D., Fan Q., Wang X., Ning T., Liu R., Zhang C.Y., Zen K., Chen X., Ba Y.: Serum miRNA expression profile as a prognostic biomarker of stage II/III colorectal adenocarcinoma. Sci. Rep., 2015; 5: 12921 LiJ. LiuY. WangC. DengT. LiangH. WangY. HuangD. FanQ. WangX. NingT. LiuR. ZhangC.Y. ZenK. ChenX. BaY. Serum miRNA expression profile as a prognostic biomarker of stage II/III colorectal adenocarcinoma Sci. Rep. 2015 5 12921 10.1038/srep12921452822926250939 Search in Google Scholar

[50] Li X.X., Gao S.Y., Wang P.Y., Zhou X., Li Y.J., Yu Y., Yan Y.F., Zhang H.H., Lv C.J., Zhou H.H., Xie S.Y.: Reduced expression levels of let-7c in human breast cancer patients. Oncol. Lett., 2015; 9: 1207–1212 LiX.X. GaoS.Y. WangP.Y. ZhouX. LiY.J. YuY. YanY.F. ZhangH.H. LvC.J. ZhouH.H. XieS.Y. Reduced expression levels of let-7c in human breast cancer patients Oncol. Lett. 2015 9 1207 1212 10.3892/ol.2015.2877431506825663883 Search in Google Scholar

[51] Lin Q., Chen T., Lin Q., Lin G., Lin J., Chen G., Guo L.: Serum miR-19a expression correlates with worse prognosis of patients with non-small cell lung cancer. J. Surg. Oncol., 2013; 107: 767–771 LinQ. ChenT. LinQ. LinG. LinJ. ChenG. GuoL. Serum miR-19a expression correlates with worse prognosis of patients with non-small cell lung cancer J. Surg. Oncol. 2013 107 767 771 10.1002/jso.2331223609137 Search in Google Scholar

[52] Liu F., Wang X., Li J., Gu K., Lv L., Zhang S., Che D., Cao J., Jin S., Yu Y.: miR-34c-3p functions as a tumour suppressor by inhibiting eIF4E expression in non-small cell lung cancer. Cell Prolif., 2015; 48: 582–592 LiuF. WangX. LiJ. GuK. LvL. ZhangS. CheD. CaoJ. JinS. YuY. miR-34c-3p functions as a tumour suppressor by inhibiting eIF4E expression in non-small cell lung cancer Cell Prolif. 2015 48 582 592 10.1111/cpr.12201649634426250586 Search in Google Scholar

[53] Liu J., Mao Q., Liu Y., Hao X., Zhang S., Zhang J.: Analysis of miR-205 and miR-155 expression in the blood of breast cancer patients. Chin. J. Cancer Res., 2013; 25: 46–54 LiuJ. MaoQ. LiuY. HaoX. ZhangS. ZhangJ. Analysis of miR-205 and miR-155 expression in the blood of breast cancer patients Chin. J. Cancer Res. 2013 25 46 54 Search in Google Scholar

[54] Liu W.J., Xu Q., Sun L.P., Dong Q.G., He C.Y., Yuan Y.: Expression of serum let-7c, let-7i, and let-7f microRNA with its target gene, pepsinogen C, in gastric cancer and precancerous disease. Tumour Biol., 2015; 36: 3337–3343 LiuW.J. XuQ. SunL.P. DongQ.G. HeC.Y. YuanY. Expression of serum let-7c, let-7i, and let-7f microRNA with its target gene, pepsinogen C, in gastric cancer and precancerous disease Tumour Biol. 2015 36 3337 3343 10.1007/s13277-014-2967-925549793 Search in Google Scholar

[55] Liu X., Feng J., Tang L., Liao L., Xu Q., Zhu S.: The regulation and function of miR-21-FOXO3a-miR-34b/c signaling in breast cancer. Int. J. Mol. Sci., 2015; 16: 3148–3162 LiuX. FengJ. TangL. LiaoL. XuQ. ZhuS. The regulation and function of miR-21-FOXO3a-miR-34b/c signaling in breast cancer Int. J. Mol. Sci. 2015 16 3148 3162 10.3390/ijms16023148434688525647415 Search in Google Scholar

[56] Liu X.G., Zhu W.Y., Huang Y.Y., Ma L.N., Zhou S.Q., Wang Y.K., Zeng F., Zhou J.H., Zhang Y.K.: High expression of serum miR-21 and tumor miR-200c associated with poor prognosis in patients with lung cancer. Med. Oncol., 2012; 29: 618–626 LiuX.G. ZhuW.Y. HuangY.Y. MaL.N. ZhouS.Q. WangY.K. ZengF. ZhouJ.H. ZhangY.K. High expression of serum miR-21 and tumor miR-200c associated with poor prognosis in patients with lung cancer Med. Oncol. 2012 29 618 626 10.1007/s12032-011-9923-y21516486 Search in Google Scholar

[57] Lu J., Zhan Y., Feng J., Luo J., Fan S.: MicroRNAs associated with therapy of non-small cell lung cancer. Int. J. Biol. Sci., 2018; 14: 390–397 LuJ. ZhanY. FengJ. LuoJ. FanS. MicroRNAs associated with therapy of non-small cell lung cancer Int. J. Biol. Sci. 2018 14 390 397 10.7150/ijbs.22243593047129725260 Search in Google Scholar

[58] Ma G.J., Gu R.M., Zhu M., Wen X., Li J.T., Zhang Y.Y., Zhang X.M., Chen S.Q.: Plasma post-operative miR-21 expression in the prognosis of gastric cancers. Asian Pac. J. Cancer Prev., 2013; 14: 7551–7554 MaG.J. GuR.M. ZhuM. WenX. LiJ.T. ZhangY.Y. ZhangX.M. ChenS.Q. Plasma post-operative miR-21 expression in the prognosis of gastric cancers Asian Pac. J. Cancer Prev. 2013 14 7551 7554 10.7314/APJCP.2013.14.12.755124460332 Search in Google Scholar

[59] Mar-Aguilar F., Mendoza-Ramirez J.A., Malagón-Santiago I., Espino-Silva P.K., Santuario-Facio S.K., Ruiz-Flores P., Rodriguez-Padilla C., Reséndez-Pérez D.: Serum circulating microRNA profiling for identification of potential breast cancer biomarkers. Dis. Markers, 2013; 34: 163–169 Mar-AguilarF. Mendoza-RamirezJ.A. Malagón-SantiagoI. Espino-SilvaP.K. Santuario-FacioS.K. Ruiz-FloresP. Rodriguez-PadillaC. Reséndez-PérezD. Serum circulating microRNA profiling for identification of potential breast cancer biomarkers Dis. Markers 2013 34 163 169 10.1155/2013/259454 Search in Google Scholar

[60] Matamala N., Vargas M.T., Gonzalez-Cámpora R., Miñambres R., Arias J.I., Menéndez P., Andrés-León E., Gómez-López G., Yanowsky K., Calvete-Candenas J., Inglada-Pérez L., Martínez-Delgado B., Benítez J.: Tumor microRNA expression profiling identifies circulating microRNAs for early breast cancer detection. Clin. Chem., 2015; 61: 1098–1106 MatamalaN. VargasM.T. Gonzalez-CámporaR. MiñambresR. AriasJ.I. MenéndezP. Andrés-LeónE. Gómez-LópezG. YanowskyK. Calvete-CandenasJ. Inglada-PérezL. Martínez-DelgadoB. BenítezJ. Tumor microRNA expression profiling identifies circulating microRNAs for early breast cancer detection Clin. Chem. 2015 61 1098 1106 10.1373/clinchem.2015.23869126056355 Search in Google Scholar

[61] Matsumura T., Sugimachi K., Iinuma H., Takahashi Y., Kurashige J., Sawada G., Ueda M., Uchi R., Ueo H., Takano Y., Shinden Y., Eguchi H., Yamamoto H., Doki Y., Mori M. i wsp.: Exosomal microRNA in serum is a novel biomarker of recurrence in human colorectal cancer. Br. J. Cancer, 2015; 113: 275–281 MatsumuraT. SugimachiK. IinumaH. TakahashiY. KurashigeJ. SawadaG. UedaM. UchiR. UeoH. TakanoY. ShindenY. EguchiH. YamamotoH. DokiY. MoriM. Exosomal microRNA in serum is a novel biomarker of recurrence in human colorectal cancer Br. J. Cancer 2015 113 275 281 10.1038/bjc.2015.201450638726057451 Search in Google Scholar

[62] Mazzoccoli G., Colangelo T., Panza A., Rubino R., Tiberio C., Palumbo O., Carella M., Trombetta D., Gentile A., Tavano F., Valvano M.R., Storlazzi C.T., Macchia G., De Cata A., Bisceglia G. i wsp.: Analysis of clock gene-miRNA correlation networks reveals candidate drivers in colorectal cancer. Oncotarget, 2016; 7: 45444–45461 MazzoccoliG. ColangeloT. PanzaA. RubinoR. TiberioC. PalumboO. CarellaM. TrombettaD. GentileA. TavanoF. ValvanoM.R. StorlazziC.T. MacchiaG. De CataA. BiscegliaG. i wsp. Analysis of clock gene-miRNA correlation networks reveals candidate drivers in colorectal cancer Oncotarget 2016 7 45444 45461 10.18632/oncotarget.9989521673327323779 Search in Google Scholar

[63] Mishra A.K., Yadav P., Mishra A.: A systemic review on staphylococcal scalded skin syndrome (SSSS): A rare and critical disease of neonates. Open Microbiol. J., 2016; 10: 150–159 MishraA.K. YadavP. MishraA. A systemic review on staphylococcal scalded skin syndrome (SSSS): A rare and critical disease of neonates Open Microbiol. J. 2016 10 150 159 10.2174/1874285801610010150501208027651848 Search in Google Scholar

[64] Muhammad N., Bhattacharya S., Steele R., Ray R.B.: Anti-miR-203 suppresses ER-positive breast cancer growth and stemness by targeting SOCS3. Oncotarget, 2016; 7: 58595–58605 MuhammadN. BhattacharyaS. SteeleR. RayR.B. Anti-miR-203 suppresses ER-positive breast cancer growth and stemness by targeting SOCS3 Oncotarget 2016 7 58595 58605 10.18632/oncotarget.11193529545627517632 Search in Google Scholar

[65] Mullick Chowdhury S., Wang T.Y., Bachawal S., Devulapally R., Choe J.W., Abou Elkacem L., Yakub B.K., Wang D.S., Tian L., Paulmurugan R., Willmann J.K.: Ultrasound-guided therapeutic modulation of hepatocellular carcinoma using complementary microRNAs. J. Control Release, 2016; 238: 272–280 Mullick ChowdhuryS. WangT.Y. BachawalS. DevulapallyR. ChoeJ.W. Abou ElkacemL. YakubB.K. WangD.S. TianL. PaulmuruganR. WillmannJ.K. Ultrasound-guided therapeutic modulation of hepatocellular carcinoma using complementary microRNAs J. Control Release 2016 238 272 280 10.1016/j.jconrel.2016.08.005518560027503707 Search in Google Scholar

[66] Napoli C., Lemieux C., Jorgensen R.: Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans. Plant Cell, 1990; 2: 279–289 NapoliC. LemieuxC. JorgensenR. Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans Plant Cell 1990 2 279 289 10.2307/3869076 Search in Google Scholar

[67] Ogata-Kawata H., Izumiya M., Kurioka D., Honma Y., Yamada Y., Furuta K., Gunji T., Ohta H., Okamoto H., Sonoda H., Watanabe M., Nakagama H., Yokota J., Kohno T., Tsuchiya N.: Circulating exosomal microRNAs as biomarkers of colon cancer. PLoS One, 2014; 9: e92921 Ogata-KawataH. IzumiyaM. KuriokaD. HonmaY. YamadaY. FurutaK. GunjiT. OhtaH. OkamotoH. SonodaH. WatanabeM. NakagamaH. YokotaJ. KohnoT. TsuchiyaN. Circulating exosomal microRNAs as biomarkers of colon cancer PLoS One 2014 9 e92921 10.1371/journal.pone.0092921397627524705249 Search in Google Scholar

[68] Okabe H., Satoh S., Furukawa Y., Kato T., Hasegawa S., Nakajima Y., Yamaoka Y., Nakamura Y.: Involvement of PEG10 in human hepatocellular carcinogenesis through interaction with SIAH1. Cancer Res., 2003; 63: 3043–3048 OkabeH. SatohS. FurukawaY. KatoT. HasegawaS. NakajimaY. YamaokaY. NakamuraY. Involvement of PEG10 in human hepatocellular carcinogenesis through interaction with SIAH1 Cancer Res. 2003 63 3043 3048 Search in Google Scholar

[69] Peng Y., Zhang X., Ma Q., Yan R., Qin Y., Zhao Y., Cheng Y., Yang M., Wang Q., Feng X., Huang Y., Huang W., Zhao Z., Wang L., Wei Y. i wsp.: MiRNA-194 activates the Wnt/β-catenin signaling pathway in gastric cancer by targeting the negative Wnt regulator, SUFU. Cancer Lett., 2017; 385: 117–127 PengY. ZhangX. MaQ. YanR. QinY. ZhaoY. ChengY. YangM. WangQ. FengX. HuangY. HuangW. ZhaoZ. WangL. WeiY. MiRNA-194 activates the Wnt/β-catenin signaling pathway in gastric cancer by targeting the negative Wnt regulator, SUFU Cancer Lett. 2017 385 117 127 10.1016/j.canlet.2016.10.03527810403 Search in Google Scholar

[70] Price C., Chen J.: MicroRNAs in cancer biology and therapy: Current status and perspectives. Genes Dis., 2014; 1: 53–63 PriceC. ChenJ. MicroRNAs in cancer biology and therapy: Current status and perspectives Genes Dis. 2014 1 53 63 10.1016/j.gendis.2014.06.004424981525473652 Search in Google Scholar

[71] Rani S., Gately K., Crown J., O’Byrne K., O’Driscoll L.: Global analysis of serum microRNAs as potential biomarkers for lung adenocarcinoma. Cancer Biol. Ther., 2013; 14: 1104–1112 RaniS. GatelyK. CrownJ. O’ByrneK. O’DriscollL. Global analysis of serum microRNAs as potential biomarkers for lung adenocarcinoma Cancer Biol. Ther. 2013 14 1104 1112 10.4161/cbt.26370391203324025412 Search in Google Scholar

[72] Roth C., Kasimir-Bauer S., Pantel K., Schwarzenbach H.: Screening for circulating nucleic acids and caspase activity in the peripheral blood as potential diagnostic tools in lung cancer. Mol. Oncol., 2011; 5: 281–291 RothC. Kasimir-BauerS. PantelK. SchwarzenbachH. Screening for circulating nucleic acids and caspase activity in the peripheral blood as potential diagnostic tools in lung cancer Mol. Oncol. 2011 5 281 291 10.1016/j.molonc.2011.02.002552829221398193 Search in Google Scholar

[73] Ru P., Steele R., Hsueh E.C., Ray R.B.: Anti-miR-203 upregulates SOCS3 expression in breast cancer cells and enhances cisplatin chemosensitivity. Genes Cancer, 2011; 2: 720–727 RuP. SteeleR. HsuehE.C. RayR.B. Anti-miR-203 upregulates SOCS3 expression in breast cancer cells and enhances cisplatin chemosensitivity Genes Cancer 2011 2 720 727 10.1177/1947601911425832321840922207897 Search in Google Scholar

[74] Salem O., Erdem N., Jung J., Münstermann E., Wörner A., Wilhelm H., Wiemann S., Körner C.: The highly expressed 5′isomiR of hsa-miR-140-3p contributes to the tumor-suppressive effects of miR-140 by reducing breast cancer proliferation and migration. BMC Genomics, 2016; 17: 566 SalemO. ErdemN. JungJ. MünstermannE. WörnerA. WilhelmH. WiemannS. KörnerC. The highly expressed 5′isomiR of hsa-miR-140-3p contributes to the tumor-suppressive effects of miR-140 by reducing breast cancer proliferation and migration BMC Genomics 2016 17 566 10.1186/s12864-016-2869-x497769427502506 Search in Google Scholar

[75] Sassen S., Miska E.A., Caldas C.: MicroRNA: Implications for cancer. Virchows Arch., 2008; 452: 1–10 SassenS. MiskaE.A. CaldasC. MicroRNA: Implications for cancer Virchows Arch. 2008 452 1 10 10.1007/s00428-007-0532-2215113118040713 Search in Google Scholar

[76] Setoyama T., Ling H., Natsugoe S., Calin G.A.: Non-coding RNAs for medical practice in oncology. Keio J. Med, 2011; 60: 106–113 SetoyamaT. LingH. NatsugoeS. CalinG.A. Non-coding RNAs for medical practice in oncology Keio J. Med 2011 60 106 113 10.2302/kjm.60.10622200634 Search in Google Scholar

[77] Shiotani A., Murao T., Kimura Y., Matsumoto H., Kamada T., Kusunoki H., Inoue K., Uedo N., Iishi H., Haruma K.: Identification of serum miRNAs as novel non-invasive biomarkers for detection of high risk for early gastric cancer. Br. J. Cancer, 2013; 109: 2323–2330 ShiotaniA. MuraoT. KimuraY. MatsumotoH. KamadaT. KusunokiH. InoueK. UedoN. IishiH. HarumaK. Identification of serum miRNAs as novel non-invasive biomarkers for detection of high risk for early gastric cancer Br. J. Cancer 2013 109 2323 2330 10.1038/bjc.2013.596381733424104965 Search in Google Scholar

[78] Shyu Y.C., Lee T.L., Lu M.J., Chen J.R., Chien R.N., Chen H.Y., Lin J.F., Tsou A.P., Chen Y.H., Hsieh C.W., Huang T.S.: miR-122-mediated translational repression of PEG10 and its suppression in human hepatocellular carcinoma. J. Transl. Med., 2016; 14: 200 ShyuY.C. LeeT.L. LuM.J. ChenJ.R. ChienR.N. ChenH.Y. LinJ.F. TsouA.P. ChenY.H. HsiehC.W. HuangT.S. miR-122-mediated translational repression of PEG10 and its suppression in human hepatocellular carcinoma J. Transl. Med. 2016 14 200 10.1186/s12967-016-0956-z493056927370270 Search in Google Scholar

[79] Silva J., García V., Zaballos Á., Provencio M., Lombardía L., Almonacid L., García J.M., Domínguez G., Peña C., Diaz R., Herrera M., Varela A., Bonilla F.: Vesicle-related microRNAs in plasma of nonsmall cell lung cancer patients and correlation with survival. Eur. Respir. J., 2011; 37: 617–623 SilvaJ. GarcíaV. ZaballosÁ. ProvencioM. LombardíaL. AlmonacidL. GarcíaJ.M. DomínguezG. PeñaC. DiazR. HerreraM. VarelaA. BonillaF. Vesicle-related microRNAs in plasma of nonsmall cell lung cancer patients and correlation with survival Eur. Respir. J. 2011 37 617 623 10.1183/09031936.0002961020595154 Search in Google Scholar

[80] Song X., Xin N., Wang W., Zhao C.: Wnt/β-catenin, an oncogenic pathway targeted by H. pylori in gastric carcinogenesis. Oncotarget, 2015; 6: 35579–35588 SongX. XinN. WangW. ZhaoC. Wnt/β-catenin, an oncogenic pathway targeted by H. pylori in gastric carcinogenesis Oncotarget 2015 6 35579 35588 10.18632/oncotarget.5758474212626417932 Search in Google Scholar

[81] Stahlhut Espinosa C.E., Slack F.J.: The role of microRNAs in cancer. Yale J. Biol. Med., 2006; 79: 131–140 Stahlhut EspinosaC.E. SlackF.J. The role of microRNAs in cancer Yale J. Biol. Med. 2006 79 131 140 Search in Google Scholar

[82] Sun Y., Wang M., Lin G., Sun S., Li X., Qi J., Li J.: Serum micro-RNA-155 as a potential biomarker to track disease in breast cancer. PLoS One, 2012; 7: e47003 SunY. WangM. LinG. SunS. LiX. QiJ. LiJ. Serum micro-RNA-155 as a potential biomarker to track disease in breast cancer PLoS One 2012 7 e47003 10.1371/journal.pone.0047003346856523071695 Search in Google Scholar

[83] Tagscherer K.E., Fassl A., Sinkovic T., Richter J., Schecher S., Macher-Goeppinger S., Roth W.: MicroRNA-210 induces apoptosis in colorectal cancer via induction of reactive oxygen. Cancer Cell Int., 2016; 16: 42 TagschererK.E. FasslA. SinkovicT. RichterJ. SchecherS. Macher-GoeppingerS. RothW. MicroRNA-210 induces apoptosis in colorectal cancer via induction of reactive oxygen Cancer Cell Int. 2016 16 42 10.1186/s12935-016-0321-6490146327293381 Search in Google Scholar

[84] Telonis A.G., Loher P., Jing Y., Londin E., Rigoutsos I.: Beyond the one-locus-one-miRNA paradigm: microRNA isoforms enable deeper insights into breast cancer heterogeneity. Nucleic Acids Res., 2015; 43: 9158–9175 TelonisA.G. LoherP. JingY. LondinE. RigoutsosI. Beyond the one-locus-one-miRNA paradigm: microRNA isoforms enable deeper insights into breast cancer heterogeneity Nucleic Acids Res. 2015 43 9158 9175 10.1093/nar/gkv922462708426400174 Search in Google Scholar

[85] Teplyuk N.M., Mollenhauer B., Gabriely G., Giese A., Kim E., Smolsky M., Kim R.Y., Saria M.G., Pastorino S., Kesari S., Krichevsky A.M.: MicroRNAs in cerebrospinal fluid identify glioblastoma and metastatic brain cancers and reflect disease activity. Neuro. Oncol., 2012; 14: 689–700 TeplyukN.M. MollenhauerB. GabrielyG. GieseA. KimE. SmolskyM. KimR.Y. SariaM.G. PastorinoS. KesariS. KrichevskyA.M. MicroRNAs in cerebrospinal fluid identify glioblastoma and metastatic brain cancers and reflect disease activity Neuro. Oncol. 2012 14 689 700 10.1093/neuonc/nos074336784522492962 Search in Google Scholar

[86] Toiyama Y., Takahashi M., Hur K., Nagasaka T., Tanaka K., Inoue Y., Kusunoki M., Boland C.R., Goel A.: Serum miR-21 as a diagnostic and prognostic biomarker in colorectal cancer. J. Natl. Cancer Inst., 2013; 105: 849–859 ToiyamaY. TakahashiM. HurK. NagasakaT. TanakaK. InoueY. KusunokiM. BolandC.R. GoelA. Serum miR-21 as a diagnostic and prognostic biomarker in colorectal cancer J. Natl. Cancer Inst. 2013 105 849 859 10.1093/jnci/djt101368736923704278 Search in Google Scholar

[87] Torre L.A., Bray F., Siegel R.L., Ferlay J., Lortet-Tieulent J., Jemal A.: Global cancer statistics. 2012. CA Cancer J. Clin., 2015; 65: 87–108 TorreL.A. BrayF. SiegelR.L. FerlayJ. Lortet-TieulentJ. JemalA. Global cancer statistics. 2012 CA Cancer J. Clin. 2015 65 87 108 10.3322/caac.2126225651787 Search in Google Scholar

[88] Tsujiura M., Ichikawa D., Komatsu S., Shiozaki A., Takeshita H., Kosuga T., Konishi H., Morimura R., Deguchi K., Fujiwara H., Okamoto K., Otsuji E.: Circulating microRNAs in plasma of patients with gastric cancers. Br. J. Cancer, 2010; 102: 1174–1179 TsujiuraM. IchikawaD. KomatsuS. ShiozakiA. TakeshitaH. KosugaT. KonishiH. MorimuraR. DeguchiK. FujiwaraH. OkamotoK. OtsujiE. Circulating microRNAs in plasma of patients with gastric cancers Br. J. Cancer 2010 102 1174 1179 10.1038/sj.bjc.6605608285309720234369 Search in Google Scholar

[89] Tsujiura M., Komatsu S., Ichikawa D., Shiozaki A., Konishi H., Takeshita H., Moriumura R., Nagata H., Kawaguchi T., Hirajima S., Arita T., Fujiwara H., Okamoto K., Otsuji E.: Circulating miR-18a in plasma contributes to cancer detection and monitoring in patients with gastric cancer. Gastric Cancer, 2015; 18: 271–279 TsujiuraM. KomatsuS. IchikawaD. ShiozakiA. KonishiH. TakeshitaH. MoriumuraR. NagataH. KawaguchiT. HirajimaS. AritaT. FujiwaraH. OkamotoK. OtsujiE. Circulating miR-18a in plasma contributes to cancer detection and monitoring in patients with gastric cancer Gastric Cancer 2015 18 271 279 10.1007/s10120-014-0363-124626859 Search in Google Scholar

[90] Wang F., Hou J., Jin W., Li J., Yue Y., Jin H., Wang X.: Increased circulating microRNA-155 as a potential biomarker for breast cancer screening: A meta-analysis. Molecules, 2014; 19: 6282–6293 WangF. HouJ. JinW. LiJ. YueY. JinH. WangX. Increased circulating microRNA-155 as a potential biomarker for breast cancer screening: A meta-analysis Molecules 2014 19 6282 6293 10.3390/molecules19056282627098824840899 Search in Google Scholar

[91] Wang G., Wang L., Sun S., Wu J., Wang Q.: Quantitative measurement of serum microRNA-21 expression in relation to breast cancer metastasis in Chinese females. Ann. Lab. Med., 2015; 35: 226–232 WangG. WangL. SunS. WuJ. WangQ. Quantitative measurement of serum microRNA-21 expression in relation to breast cancer metastasis in Chinese females Ann. Lab. Med. 2015 35 226 232 10.3343/alm.2015.35.2.226433017325729725 Search in Google Scholar

[92] Wang H., Hou L., Li A., Duan Y., Gao H., Song X.: Expression of serum exosomal microRNA-21 in human hepatocellular carcinoma. Biomed. Res. Int., 2014; 2014: 864894 WangH. HouL. LiA. DuanY. GaoH. SongX. Expression of serum exosomal microRNA-21 in human hepatocellular carcinoma Biomed. Res. Int. 2014 2014 864894 10.1155/2014/864894405214524963487 Search in Google Scholar

[93] Wang H., Wang L., Wu Z., Sun R., Jin H., Ma J., Liu L., Ling R., Yi J., Wang L., Bian J., Chen J., Li N., Yuan S., Yun J.: Three dysregulated microRNAs in serum as novel biomarkers for gastric cancer screening. Med. Oncol., 2014; 31: 298 WangH. WangL. WuZ. SunR. JinH. MaJ. LiuL. LingR. YiJ. WangL. BianJ. ChenJ. LiN. YuanS. YunJ. Three dysregulated microRNAs in serum as novel biomarkers for gastric cancer screening Med. Oncol. 2014 31 298 10.1007/s12032-014-0298-825367852 Search in Google Scholar

[94] Wang L.G., Gu J.: Serum microRNA-29a is a promising novel marker for early detection of colorectal liver metastasis. Cancer Epidemiol., 2012; 36: e61–e67 WangL.G. GuJ. Serum microRNA-29a is a promising novel marker for early detection of colorectal liver metastasis Cancer Epidemiol. 2012 36 e61 e67 10.1016/j.canep.2011.05.00222018950 Search in Google Scholar

[95] Wang R.J., Zheng Y.H., Wang P., Zhang J.Z.: Serum miR-125a-5p, miR-145 and miR-146a as diagnostic biomarkers in non-small cell lung cancer. Int. J. Clin. Exp. Pathol., 2015; 8: 765–771 WangR.J. ZhengY.H. WangP. ZhangJ.Z. Serum miR-125a-5p, miR-145 and miR-146a as diagnostic biomarkers in non-small cell lung cancer Int. J. Clin. Exp. Pathol. 2015 8 765 771 Search in Google Scholar

[96] WHO: Cancer Fact Sheets. https://www.who.int/news-room/fact-sheets/detail/cancer (31.10.2018) WHO Cancer Fact Sheets https://www.who.int/news-room/fact-sheets/detail/cancer (31.10.2018) Search in Google Scholar

[97] Wu C., Cao Y., He Z., He J., Hu C., Duan H., Jiang J.: Serum levels of miR-19b and miR-146a as prognostic biomarkers for non-small cell lung cancer. Tohoku J. Exp. Med., 2014; 232: 85–95 WuC. CaoY. HeZ. HeJ. HuC. DuanH. JiangJ. Serum levels of miR-19b and miR-146a as prognostic biomarkers for non-small cell lung cancer Tohoku J. Exp. Med. 2014 232 85 95 10.1620/tjem.232.8524531034 Search in Google Scholar

[98] Wu H.H., Lin W.C., Tsai K.W.: Advances in molecular biomarkers for gastric cancer: miRNAs as emerging novel cancer markers. Expert Rev. Mol. Med., 2014; 16: e1 WuH.H. LinW.C. TsaiK.W. Advances in molecular biomarkers for gastric cancer: miRNAs as emerging novel cancer markers Expert Rev. Mol. Med. 2014 16 e1 10.1017/erm.2013.16390862724456939 Search in Google Scholar

[99] Wu J., Li G., Wang Z., Yao Y., Chen R., Pu X.Y., Wang J.: Circulating microRNA-21 is a potential diagnostic biomarker in gastric cancer. Dis. Markers, 2015; 2015: 435656 WuJ. LiG. WangZ. YaoY. ChenR. PuX.Y. WangJ. Circulating microRNA-21 is a potential diagnostic biomarker in gastric cancer Dis. Markers 2015 2015 435656 10.1155/2015/435656443367926063956 Search in Google Scholar

[100] Wu Q., Lu Z., Li H., Lu J., Guo L., Ge Q.: Next-generation sequencing of microRNAs for breast cancer detection. J. Biomed. Biotechnol., 2011; 2011: 597145 WuQ. LuZ. LiH. LuJ. GuoL. GeQ. Next-generation sequencing of microRNAs for breast cancer detection J. Biomed. Biotechnol. 2011 2011 597145 10.1155/2011/597145311828921716661 Search in Google Scholar

[101] Wu Q., Wang C., Lu Z., Guo L., Ge Q.: Analysis of serum genome-wide microRNAs for breast cancer detection. Clin. Chim. Acta, 2012; 413: 1058–1065 WuQ. WangC. LuZ. GuoL. GeQ. Analysis of serum genome-wide microRNAs for breast cancer detection Clin. Chim. Acta 2012 413 1058 1065 10.1016/j.cca.2012.02.01622387599 Search in Google Scholar

[102] Wu X., Somlo G., Yu Y., Palomares M.R., Li A.X., Zhou W., Chow A., Yen Y., Rossi J.J., Gao H., Wang J., Yuan Y.C., Frankel P., Li S., Ashing-Giwa K.T. i wsp.: De novo sequencing of circulating miRNAs identifies novel markers predicting clinical outcome of locally advanced breast cancer. J. Transl. Med., 2012; 10: 42 WuX. SomloG. YuY. PalomaresM.R. LiA.X. ZhouW. ChowA. YenY. RossiJ.J. GaoH. WangJ. YuanY.C. FrankelP. LiS. Ashing-GiwaK.T. De novo sequencing of circulating miRNAs identifies novel markers predicting clinical outcome of locally advanced breast cancer J. Transl. Med. 2012 10 42 10.1186/1479-5876-10-42334215022400902 Search in Google Scholar

[103] Xiao B., Zhu E.D., Li N., Lu D.S., Li W., Li B.S., Zhao Y.L., Mao X.H., Guo G., Yu P.W., Zou Q.M.: Increased miR-146a in gastric cancer directly targets SMAD4 and is involved in modulating cell proliferation and apoptosis. Oncol. Rep., 2012; 27: 559–566 XiaoB. ZhuE.D. LiN. LuD.S. LiW. LiB.S. ZhaoY.L. MaoX.H. GuoG. YuP.W. ZouQ.M. Increased miR-146a in gastric cancer directly targets SMAD4 and is involved in modulating cell proliferation and apoptosis Oncol. Rep. 2012 27 559 566 Search in Google Scholar

[104] Xu L., Li M., Wang M., Yan D., Feng G., An G.: The expression of microRNA-375 in plasma and tissue is matched in human colorectal cancer. BMC Cancer, 2014; 14: 714 XuL. LiM. WangM. YanD. FengG. AnG. The expression of microRNA-375 in plasma and tissue is matched in human colorectal cancer BMC Cancer 2014 14 714 10.1186/1471-2407-14-714418138825255814 Search in Google Scholar

[105] Yang I.P., Tsai H.L., Huang C.W., Huang M.Y., Hou M.F., Juo S.H., Wang J.Y.: The functional significance of microRNA-29c in patients with colorectal cancer: A potential circulating biomarker for predicting early relapse. PLoS One, 2013; 8: e66842 YangI.P. TsaiH.L. HuangC.W. HuangM.Y. HouM.F. JuoS.H. WangJ.Y. The functional significance of microRNA-29c in patients with colorectal cancer: A potential circulating biomarker for predicting early relapse PLoS One 2013 8 e66842 10.1371/journal.pone.0066842369600323840538 Search in Google Scholar

[106] Yang J.S., Li B.J., Lu H.W., Chen Y., Lu C., Zhu R.X., Liu S.H., Yi Q.T., Li J., Song C.H.: Serum miR-152, miR-148a, miR-148b, and miR-21 as novel biomarkers in non-small cell lung cancer screening. Tumour Biol., 2015; 36: 3035–3042 YangJ.S. LiB.J. LuH.W. ChenY. LuC. ZhuR.X. LiuS.H. YiQ.T. LiJ. SongC.H. Serum miR-152, miR-148a, miR-148b, and miR-21 as novel biomarkers in non-small cell lung cancer screening Tumour Biol. 2015 36 3035 3042 10.1007/s13277-014-2938-125501703 Search in Google Scholar

[107] Yau T.O., Wu C.W., Dong Y., Tang C.M., Ng S.S., Chan F.K., Sung J.J., Yu J.: microRNA-221 and microRNA-18a identification in stool as potential biomarkers for the non-invasive diagnosis of colorectal carcinoma. Br. J. Cancer, 2014; 111: 1765–1771 YauT.O. WuC.W. DongY. TangC.M. NgS.S. ChanF.K. SungJ.J. YuJ. microRNA-221 and microRNA-18a identification in stool as potential biomarkers for the non-invasive diagnosis of colorectal carcinoma Br. J. Cancer 2014 111 1765 1771 10.1038/bjc.2014.484445373625233396 Search in Google Scholar

[108] Yau T.O., Wu C.W., Tang C.M., Chen Y., Fang J., Dong Y., Liang Q., Ng S.S., Chan F.K., Sung J.J., Yu J.: MicroRNA-20a in human faeces as a non-invasive biomarker for colorectal cancer. Oncotarget, 2016; 7: 1559–1568 YauT.O. WuC.W. TangC.M. ChenY. FangJ. DongY. LiangQ. NgS.S. ChanF.K. SungJ.J. YuJ. MicroRNA-20a in human faeces as a non-invasive biomarker for colorectal cancer Oncotarget 2016 7 1559 1568 10.18632/oncotarget.6403481148026621842 Search in Google Scholar

[109] Yin J., Bai Z., Song J., Yang Y., Wang J., Han W., Zhang J., Meng H., Ma X., Yang Y., Wang T., Li W., Zhang Z.: Differential expression of serum miR-126, miR-141 and miR-21 as novel biomarkers for early detection of liver metastasis in colorectal cancer. Chin. J. Cancer Res., 2014; 26: 95–103 YinJ. BaiZ. SongJ. YangY. WangJ. HanW. ZhangJ. MengH. MaX. YangY. WangT. LiW. ZhangZ. Differential expression of serum miR-126, miR-141 and miR-21 as novel biomarkers for early detection of liver metastasis in colorectal cancer Chin. J. Cancer Res. 2014 26 95 103 Search in Google Scholar

[110] Yu H., Jiang L., Sun C., Li Guo L., Lin M., Huang J., Zhu L.: Decreased circulating miR-375: A potential biomarker for patients with non-small-cell lung cancer. Gene, 2014; 534: 60–65 YuH. JiangL. SunC. Li GuoL. LinM. HuangJ. ZhuL. Decreased circulating miR-375: A potential biomarker for patients with non-small-cell lung cancer Gene 2014 534 60 65 10.1016/j.gene.2013.10.024 Search in Google Scholar

[111] Yuan R., Wang G., Xu Z., Zhao H., Chen H., Han Y., Wang B., Zhou J., Hu H., Guo Z., Shen H., Xue X.: Up-regulated circulating miR-106a by DNA methylation promised a potential diagnostic and prognostic marker for gastric cancer. Anticancer Agents Med. Chem., 2016; 16: 1093–1100 YuanR. WangG. XuZ. ZhaoH. ChenH. HanY. WangB. ZhouJ. HuH. GuoZ. ShenH. XueX. Up-regulated circulating miR-106a by DNA methylation promised a potential diagnostic and prognostic marker for gastric cancer Anticancer Agents Med. Chem. 2016 16 1093 1100 10.2174/187152061566615071611065726179261 Search in Google Scholar

[112] Yuxia M., Zhennan T., Wei Z.: Circulating miR-125b is a novel biomarker for screening non-small-cell lung cancer and predicts poor prognosis. J. Cancer Res. Clin. Oncol., 2012; 138: 2045–2050 YuxiaM. ZhennanT. WeiZ. Circulating miR-125b is a novel biomarker for screening non-small-cell lung cancer and predicts poor prognosis J. Cancer Res. Clin. Oncol. 2012 138 2045 2050 10.1007/s00432-012-1285-022806310 Search in Google Scholar

[113] Zang H., Wang W., Fan S.: The role of microRNAs in resistance to targeted treatments of non-small cell lung cancer. Cancer Chemother, Pharmacol., 2017; 79: 227–231 ZangH. WangW. FanS. The role of microRNAs in resistance to targeted treatments of non-small cell lung cancer Cancer Chemother, Pharmacol. 2017 79 227 231 10.1007/s00280-016-3130-727515517 Search in Google Scholar

[114] Zeng Q., Jin C., Chen W., Xia F., Wang Q., Fan F., Du J., Guo Y., Lin C., Yang K., Li J., Peng X., Li X., Cao K.: Downregulation of serum miR-17 and miR-106b levels in gastric cancer and benign gastric diseases. Chin. J. Cancer Res., 2014; 26: 711–716 ZengQ. JinC. ChenW. XiaF. WangQ. FanF. DuJ. GuoY. LinC. YangK. LiJ. PengX. LiX. CaoK. Downregulation of serum miR-17 and miR-106b levels in gastric cancer and benign gastric diseases Chin. J. Cancer Res. 2014 26 711 716 Search in Google Scholar

[115] Zhang J., Song Y., Zhang C., Zhi X., Fu H., Ma Y., Chen Y., Pan F., Wang K., Ni J., Jin W., He X., Su H., Cui D.: Circulating MiR-16-5p and MiR-19b-3p as two novel potential biomarkers to indicate progression of gastric cancer. Theranostics, 2015; 5: 733–745 ZhangJ. SongY. ZhangC. ZhiX. FuH. MaY. ChenY. PanF. WangK. NiJ. JinW. HeX. SuH. CuiD. Circulating MiR-16-5p and MiR-19b-3p as two novel potential biomarkers to indicate progression of gastric cancer Theranostics 2015 5 733 745 10.7150/thno.10305440249725897338 Search in Google Scholar

[116] Zhang R., Wang W., Li F., Zhang H., Liu J.: MicroRNA-106b~25 expressions in tumor tissues and plasma of patients with gastric cancers. Med. Oncol., 2014; 31: 243 ZhangR. WangW. LiF. ZhangH. LiuJ. MicroRNA-106b~25 expressions in tumor tissues and plasma of patients with gastric cancers Med. Oncol. 2014 31 243 10.1007/s12032-014-0243-x25218271 Search in Google Scholar

[117] Zhao W., Zhao J.J., Zhang L., Xu Q.F., Zhao Y.M., Shi X.Y., Xu A.G.: Serum miR-21 level: A potential diagnostic and prognostic biomarker for non-small cell lung cancer. Int. J. Clin. Exp. Med., 2015; 8: 14759–14763 ZhaoW. ZhaoJ.J. ZhangL. XuQ.F. ZhaoY.M. ShiX.Y. XuA.G. Serum miR-21 level: A potential diagnostic and prognostic biomarker for non-small cell lung cancer Int. J. Clin. Exp. Med. 2015 8 14759 14763 Search in Google Scholar

[118] Zheng R., Pan L., Gao J., Ye X., Chen L., Zhang X., Tang W., Zheng W.: Prognostic value of miR-106b expression in breast cancer patients. J. Surg. Res., 2015; 195: 158–165 ZhengR. PanL. GaoJ. YeX. ChenL. ZhangX. TangW. ZhengW. Prognostic value of miR-106b expression in breast cancer patients J. Surg. Res. 2015 195 158 165 10.1016/j.jss.2014.12.03525619461 Search in Google Scholar

[119] Zhu W., He J., Chen D., Zhang B., Xu L., Ma H., Liu X., Zhang Y., Le H.: Expression of miR-29c, miR-93, and miR-429 as potential biomarkers for detection of early stage non-small lung cancer. PLoS One, 2014; 9: e87780 ZhuW. HeJ. ChenD. ZhangB. XuL. MaH. LiuX. ZhangY. LeH. Expression of miR-29c, miR-93, and miR-429 as potential biomarkers for detection of early stage non-small lung cancer PLoS One 2014 9 e87780 10.1371/journal.pone.0087780392114224523873 Search in Google Scholar

[120] Zhuang C., Jiang W., Huang D., Xu L., Yang Q., Zheng L., Wang X., Hu L.: Serum miR-21, miR-26a and miR-101 as potential bio-markers of hepatocellular carcinoma. Clin. Res. Hepatol. Gastroenterol., 2016; 40: 386–396 ZhuangC. JiangW. HuangD. XuL. YangQ. ZhengL. WangX. HuL. Serum miR-21, miR-26a and miR-101 as potential bio-markers of hepatocellular carcinoma Clin. Res. Hepatol. Gastroenterol. 2016 40 386 396 10.1016/j.clinre.2015.11.00226669589 Search in Google Scholar