Genes Controlling 2-deoxyglucose Induced Lysis and Formation of Reactive Oxygen Species in Schizosaccharomyces pombe

Apel K. and H. Hirt. 2004. Reactive oxygen species: metabolism, oxidative stress, and signal transduction. Annu. Rev. Plant Biol. 55: 373–399. Search in Google Scholar

Biely P., Z. Krátký, J. Kovařík and Š. Bauer. 1971. Effect of 2-deoxy- glucose on cell wall formation in Saccharomyces cerevisiae and its relation to cell growth inhibition. J. Bacteriol. 107: 121–129.10.1128/jb.107.1.121-129.19712468945563864 Search in Google Scholar

Brown J. 1962. Effects of 2-deoxyglucose on carbohydrate meta- blism: review of the literature and studies in the rat. Metabolism. 11: 1098–1112. Search in Google Scholar

Coleman M.C., C.R. Asbury, D. Daniels, J. Du, N. Aykin-Burns, B.J. Smith, L. Li, D.R. Spitz and J.J. Cullen. 2008. 2-deoxy-D-glu- cose causes cytotoxicity, oxidative stress, and radiosensitization in pancreatic cancer. Free Radic. Biol. Med. 44: 322–331. Search in Google Scholar

Farkas V., A. Svoboda and S. Bauer. 1969. Inhibitory effect of 2-deoxy-d-glucose on the formation of the cell wall in yeast protoplasts. J. Bacteriol. 98: 744–748.10.1128/jb.98.2.744-748.19692848805784222 Search in Google Scholar

Goyal A. and V. Simanis. 2012. Characterization of ypa1 and ypa2, the Schizosaccharomyces pombe orthologs of the peptidyl proyl isomerases that activate PP2A, reveals a role for Ypa2p in the regulation of cytokinesis. Genetics 190: 1235–1250. Search in Google Scholar

Gupta D.R., S.K. Paul, Y. Oowatari, Y. Matsuo and M. Kawamu- kai. 2011. Complex formation, phosphorylation, and localization of protein kinase A of Schizosaccharomyces pombe upon glucose starvation. Biosci. Biotechnol. Biochem. 75: 1456–1465. Search in Google Scholar

Herrero E., J. Ros, G. Bellí and E. Cabiscol. 2008. Redox control and oxidative stress in yeast cells. Biochim. Biophys. Acta 1780: 1217–1235.10.1016/j.bbagen.2007.12.00418178164 Search in Google Scholar

Hoffman C.S., V. Wood and P.A. Fantes. 2015. An ancient yeast for young geneticists: a primer on the Schizosaccharomyces pombe model system. Genetics 201: 403–423.10.1534/genetics.115.181503459665726447128 Search in Google Scholar

Ikner A. and K. Shiozaki. 2005. Yeast signaling pathways in the oxidative stress response. Mutat. Res. 569: 13–27.10.1016/j.mrfmmm.2004.09.00615603750 Search in Google Scholar

Johnson B.F. 1968. Lysis of yeast cell walls induced by 2-deoxyglu- cose at their sites of glucan synthesis. J. Bacteriol. 95: 1169–1172.10.1128/jb.95.3.1169-1172.19682521444868355 Search in Google Scholar

Kato H., S. Kira and M. Kawamukai. 2013. The transcription factors Atf1 and Pcr1 are essential for transcriptional induction of the extracellular maltase Agl1 in fission yeast. PloS One 8: e80572.10.1371/journal.pone.0080572381825824224056 Search in Google Scholar

Krátký Z., P. Biely and Š. Bauer. 1975. Mechanism of 2-deoxy-d- glucose inhibition of cell-wall polysaccharide and glycoprotein biosyntheses in Saccharomyces cerevisiae. Eur. J. Biochem. 54: 459–467.10.1111/j.1432-1033.1975.tb04157.x1100378 Search in Google Scholar

Madrid M., T. Soto, A. Franco, V. Paredes, J. Vicente, E. Hidalgo, M. Gacto and J. Cansado. 2004. A cooperative role for Atf1 and Pap1 in the detoxification of the oxidative stress induced by glucose deprivation in Schizosaccharomyces pombe. J. Biol. Chem. 279: 41594–41602.10.1074/jbc.M40550920015247218 Search in Google Scholar

Madrid M., T. Soto, H. K. Khong, A. Franco, J. Vicente, P. Pérez, M. Gacto and J. Cansado. 2006. Stress-induced response, localization, and regulation of the Pmk1 cell integrity pathway in Schizosac- charomyces pombe. J. Biol. Chem. 281: 2033–2043. Search in Google Scholar

Madrid M., J. Fernández-Zapata, L. Sánchez-Mir, T. Soto, A. Franco, J. Vicente-Soler, M. Gacto and J. Cansado. 2013. Role of the fission yeast cell integrity MAPK pathway in response to glucose limitation. BMC Microbiol. 13: 34.10.1186/1471-2180-13-34357241923398982 Search in Google Scholar

McCartney R.R., D.G. Chandrashekarappa, B.B. Zhang and M.C. Schmidt. 2014. Genetic analysis of resistance and sensitivity to 2-deoxyglucose in Saccharomyces cerevisiae. Genetics 198: 635–646.10.1534/genetics.114.169060419661825116136 Search in Google Scholar

Megnet R. 1965. Effect of 2-deoxyglucose on Schizosaccharomyces pombe. J. Bacteriol. 90: 1032–1035.10.1128/jb.90.4.1032-1035.19653157725847793 Search in Google Scholar

Monahan B. J., J. Villén, S. Marguerat, J. Bähler, S. P. Gygi and F. Winston. 2008. Fission yeast SWI/SNF and RSC complexes show compositional and functional differences from budding yeast. Nat. Struct. Mol. Biol. 15: 873–880.10.1038/nsmb.1452255995018622392 Search in Google Scholar

O’Donnell A.F., R.R. McCartney, D.G. Chandrashekarappa, B.B. Zhang, J. Thorner and M.C. Schmidt. 2015. 2-deoxyglucose impairs Saccharomyces cerevisiae growth by stimulating Snf1-regu- lated and α-arrestin-mediated trafficking of hexose transporters 1 and 3. Mol. Cell. Biol. 35: 939–955.10.1128/MCB.01183-14433308925547292 Search in Google Scholar

Palabiyik B., C. Kig, M. Pekmez, L. Dalyan, N. Arda and G. Temizkan. 2012. Investigation of the relationship between oxidative stress and glucose signaling in Schizosaccharomyces pombe. Biochem. Genet. 50: 336–349.10.1007/s10528-011-9477-x22173629 Search in Google Scholar

Palabiyik B., F. Jafari Ghods and E. Onay Ucar. 2013. Effects of glucose sensing/signaling on oxidative stress response in glucose repression mutants of Schizosaccharomyces pombe. Genet. Mol. Res. GMR 12: 5046–5056.10.4238/2013.October.25.324301766 Search in Google Scholar

Pelicano H., D. S. Martin, R.-H. Xu and P. Huang. 2006. Glycolysis inhibition for anticancer treatment. Oncogene 25: 4633–4646.10.1038/sj.onc.120959716892078 Search in Google Scholar

Randez-Gil F., A. Blasco, J. A. Prieto and P. Sanz. 1995. DOGR1 and DOGR2: two genes from Saccharomyces cerevisiae that confer 2-deoxyglucose resistance when overexpressed. Yeast Chichester Engl. 11: 1233–1240.10.1002/yea.3201113038553694 Search in Google Scholar

Ray P.D., B.-W. Huang and Y. Tsuji. 2012. Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell. Signal. 24: 981–990.10.1016/j.cellsig.2012.01.008345447122286106 Search in Google Scholar

Roux A.E., A. Leroux, M.A. Alaamery, C.S. Hoffman, P. Chartrand, G. Ferbeyre and L.A. Rokeach. 2009. Pro-aging effects of glucose signaling through a g protein-coupled glucose receptor in fission yeast. PLoS Genet. 5: e1000408.10.1371/journal.pgen.1000408264613519266076 Search in Google Scholar

van Slegtenhorst M., A. Mustafa and E.P. Henske. 2005. Pas1, a G1 cyclin, regulates amino acid uptake and rescues a delay in G1 arrest in Tsc1 and Tsc2 mutants in Schizosaccharomyces pombe. Hum. Mol. Genet. 14: 2851–2858. Search in Google Scholar

Suslu K. G., B. Palabiyik and G. Temizkan. 2011. Genes involved in glucose repression and oxidative stress response in the fission yeast Schizosaccharomyces pombe. Genet. Mol. Res. GMR 10: 4041–4047.10.4238/2011.November.8.422095476 Search in Google Scholar

de la Torre-Ruiz M.A., N. Pujol and V. Sundaran. 2015. Coping with oxidative stress. The yeast model. Curr. Drug Targets 16: 2–12.10.2174/138945011566614102016010525330032 Search in Google Scholar

Vishwanatha A., C. Rallis, S.B. Subramanyaswamy, C.J. Michael D’Souza, J. Bähler and M.E. Schweingruber. 2016. Identification of nuclear genes affecting 2-Deoxyglucose resistance in Schizosac- charomyces pombe. FEMS Yeast Res. 16(6): fow061.10.1093/femsyr/fow061545273027481777 Search in Google Scholar

Wu D. and P. Yotnda. 2011. Production and detection of reactive oxygen species (ROS) in cancers. J. Vis. Exp. JoVE. 57.pii: 3357. 10.3791/3357330860522127014 Search in Google Scholar