Gene symbol and variants | dbSNP rs No. | MAF in Asians* | Remarks |
---|---|---|---|
rs1799853 | EAS 0.00 | Variants detected in Indian-Malaysians [ | |
SAS 0.03 | |||
rs1057910 | EAS 0.03 | ||
SAS 0.11 | |||
–1639G>A | rs9923231 | EAS 0.88 | |
SAS 0.15 | |||
1173C>T | rs9934438 | EAS 0.88 | Complete linkage disequilibrium with |
SAS 0.15 | rs9923231 in a recent study from Bangkok [ |
Number (cases) | Average warfarin dose (mg/week) | ||
---|---|---|---|
All | 154 | 31 | – |
Sex | 0.46 | ||
Male | 59 (38.3%) | 31.9 | |
Female | 95 (61.7%) | 30.4 | |
Age | < 0.01 | ||
<45 years | 81 (52.6%) | 35 | |
≥45 years | 73 (47.4%) | 26.5 | |
Body mass index | 0.31 | ||
<23.4 kg/m2 | 90 (58.4%) | 30.2 | |
≥23.4 kg/m2 | 64 (41.6%) | 32.2 | |
Body surface area | 0.02 | ||
<1.7 m2 | 103 (66.8%) | 29.4 | |
≥1.7 m2 | 51 (33.1%) | 34.3 | |
Uric acid food consumption | 0.74 | ||
Never/seldom | 144 (93.5%) | 30.9 | |
Usually | 10 (6.5%) | 32.3 | |
Green vegetable food consumption | 0.77 | ||
Never/seldom | 57 (37.3%) | 31.5 | |
Usually | 96 (62.7%) | 30.9 | |
Medication used | 0.01* (List-1) | ||
None | 102 (66.2%) | 32.7 | |
List-1 | 50 (32.5%) | 27.6 | |
List-2 | 2 (1.3%) | 29.8 | |
rs9923231 ( | <0.01** | ||
AA | 74 (48.1%) | 23.8 | |
AG | 64 (41.6%) | 35.3 | |
GG | 16 (10.4%) | 47.3 | |
rs1057910 ( | <0.01 | ||
AA (* | 144 (93.5%) | 31.7 | |
AC (* | 10 (6.5%) | 20.7 |
AA | 21.8 (21.0-24.5) | 15.8 (7.0-24.5) |
AG | 35.0 (31.6-39.9) | 24.0 (14.7-32.5) |
GG | 49.0 (35.0-56.0) | (no observation) |