<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_1905-7415.1006.526_s_001_w2aab3b7b3b1b6b1aab1c17b1Aa"><h3>Background</h3><p>Multiple sclerosis (MS) is an inflammatory disease affecting movement. MS has a worldwide distribution.</p></sec><sec id="j_1905-7415.1006.526_s_002_w2aab3b7b3b1b6b1aab1c17b2Aa"><h3>Objectives</h3><p>Early detection of MS lesions in Pakistanis by magnetic resonance imaging (MRI); to describe characteristics and to determine the association with musculoskeletal disability.</p></sec><sec id="j_1905-7415.1006.526_s_003_w2aab3b7b3b1b6b1aab1c17b3Aa"><h3>Methods</h3><p>We included 100 patients (18–65 years old) diagnosed with cases of MS from March 2012 to March 2013. A detailed clinical history of the musculoskeletal system was taken and MR imaging was performed to characterize lesions acquiring T1-weighted (T1W), T2W, proton density, fluid-attenuated inversion recovery (FLAIR), and T1W postgadolinium sequences.</p></sec><sec id="j_1905-7415.1006.526_s_004_w2aab3b7b3b1b6b1aab1c17b4Aa"><h3>Results</h3><p>Most patients belonged to a middle-aged group (42–62 years) and MS was common in women. MS lesions were found in the deep white matter of central nervous system (95 patients), supratentorially (97), periventricularly (96), juxtacortically (62), infratentorially (16), and in the temporal lobes (9). T2W sequences (99 patients detected) were superior to T1W sequences (47). By contrast, FLAIR sequence was more accurate and 100% of these cases were detected on this sequence of MRI. Muscle spasticity was found in 10 patients, muscle weakness in 53, uncoordinated movements in 7, ataxic gait in 9, and slurred speech in 3. However, numbness remained the more common clinical history (69 patients). Muscle fatigue (19), hemiparesis (8), and monoparesis in either upper and lower limbs (5) were other clinical presentations.</p></sec><sec id="j_1905-7415.1006.526_s_005_w2aab3b7b3b1b6b1aab1c17b5Aa"><h3>Conclusions</h3><p>MRI plays a pivotal role in detection and characterization of MS plaques. Clinical manifestations and imaging findings are similar to those reported from other parts of the world.</p></sec></abstract>

BackgroundMultiple sclerosis (MS) is an inflammatory disease affecting movement. MS has a worldwide distribution.ObjectivesEarly detection of MS lesions in Pakistanis by magnetic resonance imaging (MRI); to describe characteristics and to determine the association with musculoskeletal disability.MethodsWe included 100 patients (18–65 years old) diagnosed with cases of MS from March 2012 to March 2013. A detailed clinical history of the musculoskeletal system was taken and MR imaging was performed to characterize lesions acquiring T1-weighted (T1W), T2W, proton density, fluid-attenuated inversion recovery (FLAIR), and T1W postgadolinium sequences.ResultsMost patients belonged to a middle-aged group (42–62 years) and MS was common in women. MS lesions were found in the deep white matter of central nervous system (95 patients), supratentorially (97), periventricularly (96), juxtacortically (62), infratentorially (16), and in the temporal lobes (9). T2W sequences (99 patients detected) were superior to T1W sequences (47). By contrast, FLAIR sequence was more accurate and 100% of these cases were detected on this sequence of MRI. Muscle spasticity was found in 10 patients, muscle weakness in 53, uncoordinated movements in 7, ataxic gait in 9, and slurred speech in 3. However, numbness remained the more common clinical history (69 patients). Muscle fatigue (19), hemiparesis (8), and monoparesis in either upper and lower limbs (5) were other clinical presentations.ConclusionsMRI plays a pivotal role in detection and characterization of MS plaques. Clinical manifestations and imaging findings are similar to those reported from other parts of the world.

Multiple sclerosis lesions on magnetic resonance imaging, their characterization and pathological correlation with musculoskeletal disability in Pakistanis

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

BackgroundMultiple sclerosis (MS) is an inflammatory disease affecting movement. MS has a worldwide distribution.ObjectivesEarly detection of MS lesions in...

Multiple sclerosis lesions on magnetic resonance imaging, their characterization and pathological correlation with musculoskeletal disability in Pakistanis

Article Category: Original article

Published Online: Mar 31, 2017

Page range: 567 - 574

DOI: https://doi.org/10.5372/1905-7415.1006.526

Keywords
Ataxia, FLAIR, MRI, multiple sclerosis, muscle weakness, spasticity, T1W1, T2WI

© 2016 Nasir Raza Zaidi, Mian Waheed Ahmad, Riffat Mehboob

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Multiple sclerosis lesions on magnetic resonance imaging, their characterization and pathological correlation with musculoskeletal disability in Pakistanis

Article Category: Original article

Published Online: Mar 31, 2017

Page range: 567 - 574

DOI: https://doi.org/10.5372/1905-7415.1006.526

KeywordsAtaxia, FLAIR, MRI, multiple sclerosis, muscle weakness, spasticity, T1W1, T2WI

© 2016 Nasir Raza Zaidi, Mian Waheed Ahmad, Riffat Mehboob

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Ataxia, FLAIR, MRI, multiple sclerosis, muscle weakness, spasticity, T1W1, T2WI