Friedman et al. 1999 [14] | 27 weeks | IgM, polymerase chain reaction (PCR) | 28 weeks | 39 weeks | Pyrimethamine, sulfadiazine, and folinic acid (PSF) | Ventriculomegaly Ascites Pleural effusion Pericardial effusion | Chorioretinitis Periventricular calcification Normal development at 4 months |
Nowokowska et al. 2005 [12]20052005 | 27 weeks | IgG, IgM, IgG avidity, PCR | 28 weeks | 38 weeks | Spiramycin then PSF Shunt placement at 35 wks | Hydrocephalus Clubfoot | Hydrocephalus Intracranial calcifications Seizure Chorioretinitis Alive |
Tamaru et al. 2011 [13]012011 | 23 weeks | IgG, IgM | 25 weeks | 32 weeks | Sulfadoxine, pyrimethamine, azithromycin, acetylspiramycin | Ventriculomegaly Ascites Pericardial effusion Cardiomegaly Placentomegaly | Ventriculomegaly Ascites Hepatosplenomegaly Chorioretinitis Meningitis Alive at 7 months |
Present case | 31 weeks | IgG, IgM | 32 weeks | 34 weeks | PSF | Ventriculomegaly Cardiomegaly Hepatosplenomegaly Hydramnios | Ventriculomegaly Hepatosplenomegaly Iris atrophy Meningitis Neonatal death |