<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_1905-7415.1002.474_s_001_w2aab3b7b4b1b6b1aab1c16b1Aa"><h3>Background</h3><p>Autoimmune thyroid disease (AITD) is a risk factor for dry eye disease. The prevalence of dry eye in AITD is not definitely known.</p></sec><sec id="j_1905-7415.1002.474_s_002_w2aab3b7b4b1b6b1aab1c16b2Aa"><h3>Objectives</h3><p>To determine the prevalence of dry eye in AITD and its association with clinical signs of thyroid associated ophthalmopathy (TAO).</p></sec><sec id="j_1905-7415.1002.474_s_003_w2aab3b7b4b1b6b1aab1c16b3Aa"><h3>Methods</h3><p>We enrolled a cross-section of 92 patients with AITD between May 1 and August 31, 2013. All were examined to establish thyroid eye signs, and severity was classified as none, mild, and moderate-severe according to the European Group on Graves’ orbitopathy. Dry eye disease was verified using an Ocular Surface Disease Index (OSDI) questionnaire, tear break-up time (TBUT), Schirmer test, and ocular surface fluorescein staining. Features of meibomian glands were inspected. This observational study was registered at www.clinicaltrials.in.th, No. TCTR20130713001.</p></sec><sec id="j_1905-7415.1002.474_s_004_w2aab3b7b4b1b6b1aab1c16b4Aa"><h3>Results</h3><p>The prevalence of dry eye in AITD was 27% by OSDI questionnaire (95% confidence interval (CI), 16%-34%); 96% (95% CI, 93%-99%) by TBUT; 69% (95% CI, 62%-75%) by ocular surface staining; and 18% (95% CI, 12%-23%) using a Schirmer test, which associated dry eye and proptosis with an odds ratio (OR) of 9.3 (95% CI, 1.2-70.6, P = 0.031), and lagophthalmos by ocular surface staining with an OR of 5.8 (95% CI, 1.2-27.7, P = 0.026). Dry eye in patients with or without clinical signs of TAO was not significantly different.</p></sec><sec id="j_1905-7415.1002.474_s_005_w2aab3b7b4b1b6b1aab1c16b5Aa"><h3>Conclusions</h3><p>The prevalence of dry eye varied by criteria, but was not different in AITD patients with or without TAO. Proptosis and lagophthalmos were associated more strongly with dry eye disease in AITD with TAO, than without.</p></sec></abstract>

BackgroundAutoimmune thyroid disease (AITD) is a risk factor for dry eye disease. The prevalence of dry eye in AITD is not definitely known.ObjectivesTo determine the prevalence of dry eye in AITD and its association with clinical signs of thyroid associated ophthalmopathy (TAO).MethodsWe enrolled a cross-section of 92 patients with AITD between May 1 and August 31, 2013. All were examined to establish thyroid eye signs, and severity was classified as none, mild, and moderate-severe according to the European Group on Graves’ orbitopathy. Dry eye disease was verified using an Ocular Surface Disease Index (OSDI) questionnaire, tear break-up time (TBUT), Schirmer test, and ocular surface fluorescein staining. Features of meibomian glands were inspected. This observational study was registered at www.clinicaltrials.in.th, No. TCTR20130713001.ResultsThe prevalence of dry eye in AITD was 27% by OSDI questionnaire (95% confidence interval (CI), 16%-34%); 96% (95% CI, 93%-99%) by TBUT; 69% (95% CI, 62%-75%) by ocular surface staining; and 18% (95% CI, 12%-23%) using a Schirmer test, which associated dry eye and proptosis with an odds ratio (OR) of 9.3 (95% CI, 1.2-70.6, P = 0.031), and lagophthalmos by ocular surface staining with an OR of 5.8 (95% CI, 1.2-27.7, P = 0.026). Dry eye in patients with or without clinical signs of TAO was not significantly different.ConclusionsThe prevalence of dry eye varied by criteria, but was not different in AITD patients with or without TAO. Proptosis and lagophthalmos were associated more strongly with dry eye disease in AITD with TAO, than without.

Prevalence of dry eye disease in autoimmune thyroid disease and the association of dry eye with clinical signs of thyroid associated ophthalmopathy: observational, noncomparative, cross-sectional study

Chulalongkorn University and King Chulalongkorn Memorial Hospital

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

BackgroundAutoimmune thyroid disease (AITD) is a risk factor for dry eye disease. The prevalence of dry eye in AITD is not definitely known.ObjectivesTo...

Prevalence of dry eye disease in autoimmune thyroid disease and the association of dry eye with clinical signs of thyroid associated ophthalmopathy: observational, noncomparative, cross-sectional study

Article Category: Brief communication (Original)

Published Online: Jan 31, 2017

Page range: 133 - 138

DOI: https://doi.org/10.5372/1905-7415.1002.474

Keywords
AITD, autoimmune thyroid disease, dry eye, TAO, thyroid associated ophthalmopathy

© 2016 Suppapong Tirakunwichcha, Vipavee Lerdchanapornchai, Usanee Reinprayoon, Preamjit Saonanon, Thiti Snabboon

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Prevalence of dry eye disease in autoimmune thyroid disease and the association of dry eye with clinical signs of thyroid associated ophthalmopathy: observational, noncomparative, cross-sectional study

Article Category: Brief communication (Original)

Published Online: Jan 31, 2017

Page range: 133 - 138

DOI: https://doi.org/10.5372/1905-7415.1002.474

KeywordsAITD, autoimmune thyroid disease, dry eye, TAO, thyroid associated ophthalmopathy

© 2016 Suppapong Tirakunwichcha, Vipavee Lerdchanapornchai, Usanee Reinprayoon, Preamjit Saonanon, Thiti Snabboon

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
AITD, autoimmune thyroid disease, dry eye, TAO, thyroid associated ophthalmopathy