<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_1905-7415.1000.520_s_001_w2aab3b7b5b1b6b1aab1c17b1Aa"><h3>Background</h3><p> Vitamin D status of Thai patients receiving renal replacement therapy (RRT) is incompletely known.</p></sec><sec id="j_1905-7415.1000.520_s_002_w2aab3b7b5b1b6b1aab1c17b2Aa"><h3>Objectives</h3><p>To determine the prevalence of vitamin D deficiency or insufficiency in adult Thai patients receiving various RRT modalities, and factors associated with low vitamin D levels.</p></sec><sec id="j_1905-7415.1000.520_s_003_w2aab3b7b5b1b6b1aab1c17b3Aa"><h3>Methods</h3><p>In this retrospective, observational, single-center, cross-sectional study, we evaluated dialysis-related laboratory test variables from 111 patients receiving RRT. Serum 25-hydroxyvitaminD concentration [25(OH)D] &lt; 15 ng/mL was defined as deficiency, and 15–30 ng/mL as insufficiency.</p></sec><sec id="j_1905-7415.1000.520_s_004_w2aab3b7b5b1b6b1aab1c17b4Aa"><h3>Results</h3><p>Low vitamin D levels were identified in 100% patients receiving peritoneal dialysis (PD; 81% deficient, 19% insufficient), 94% patients receiving online-hemodiafiltration (OL-HDF; 50% deficient, 44% insufficient), and 100% patients with kidney transplants (KT; 55% deficient, 45% insufficient). PD patients showed significantly lower serum [25(OH)D] than OL-HDF or KT patients (10.5 ± 5.9 vs 17.7 ± 8.5 vs 15.4 ± 6.1 ng/mL respectively, <italic>P</italic> &lt; 0.001). OL-HDF patients with vitamin D deficiency had significantly lower vascular access flow than those without deficiency (833 ± 365 vs 1239 ± 385 mL/min, <italic>P</italic> = 0.008). KT recipients from deceased donors had lower serum [25(OH)D] than KT recipients from living, related donors (13.7 ± 6.0 vs 17.5 ± 5.7 ng/mL, <italic>P</italic> = 0.045). Multiple logistic regression found treatment by renin-angiotensin system blockade, serum triglyceride, and intact parathyroid hormone levels significantly associated with vitamin D deficiency after adjusting for sex, and serum calcium, phosphate, and albumin levels.</p></sec><sec id="j_1905-7415.1000.520_s_005_w2aab3b7b5b1b6b1aab1c17b5Aa"><h3>Conclusions</h3><p>Nearly 100% patients receiving RRT had vitamin D deficiency or insufficiency, and RRT modalities might be related.</p></sec></abstract>

Background Vitamin D status of Thai patients receiving renal replacement therapy (RRT) is incompletely known.ObjectivesTo determine the prevalence of vitamin D deficiency or insufficiency in adult Thai patients receiving various RRT modalities, and factors associated with low vitamin D levels.MethodsIn this retrospective, observational, single-center, cross-sectional study, we evaluated dialysis-related laboratory test variables from 111 patients receiving RRT. Serum 25-hydroxyvitaminD concentration [25(OH)D] < 15 ng/mL was defined as deficiency, and 15–30 ng/mL as insufficiency.ResultsLow vitamin D levels were identified in 100% patients receiving peritoneal dialysis (PD; 81% deficient, 19% insufficient), 94% patients receiving online-hemodiafiltration (OL-HDF; 50% deficient, 44% insufficient), and 100% patients with kidney transplants (KT; 55% deficient, 45% insufficient). PD patients showed significantly lower serum [25(OH)D] than OL-HDF or KT patients (10.5 ± 5.9 vs 17.7 ± 8.5 vs 15.4 ± 6.1 ng/mL respectively, P < 0.001). OL-HDF patients with vitamin D deficiency had significantly lower vascular access flow than those without deficiency (833 ± 365 vs 1239 ± 385 mL/min, P = 0.008). KT recipients from deceased donors had lower serum [25(OH)D] than KT recipients from living, related donors (13.7 ± 6.0 vs 17.5 ± 5.7 ng/mL, P = 0.045). Multiple logistic regression found treatment by renin-angiotensin system blockade, serum triglyceride, and intact parathyroid hormone levels significantly associated with vitamin D deficiency after adjusting for sex, and serum calcium, phosphate, and albumin levels.ConclusionsNearly 100% patients receiving RRT had vitamin D deficiency or insufficiency, and RRT modalities might be related.

Prevalence of vitamin D deficiency in Thai patients receiving various modalities of renal replacement therapy

Division of Nephrology, Department of Medicine, Faculty of Medicine

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Background Vitamin D status of Thai patients receiving renal replacement therapy (RRT) is incompletely known.ObjectivesTo determine the prevalence of vitamin D...

Prevalence of vitamin D deficiency in Thai patients receiving various modalities of renal replacement therapy

Article Category: Original article

Published Online: Mar 31, 2017

Page range: s39 - s48

DOI: https://doi.org/10.5372/1905-7415.1000.520

Keywords
prevalence, renal replacement therapy, vitamin D deficiency, 25 hydroxyvitamin D

© 2016 Piyawan Kittiskulnam, Paweena Susantitaphong, Natavudh Townamchai, Pisut Katavatin, Khajohn Tiranathanagul, Talerngsak Kanjanabuch, Yingyos Avihingsanon, Kearkiat Praditpornsilpa, Somchai Eiam-Ong

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Prevalence of vitamin D deficiency in Thai patients receiving various modalities of renal replacement therapy

Article Category: Original article

Published Online: Mar 31, 2017

Page range: s39 - s48

DOI: https://doi.org/10.5372/1905-7415.1000.520

Keywordsprevalence, renal replacement therapy, vitamin D deficiency, 25 hydroxyvitamin D

© 2016 Piyawan Kittiskulnam, Paweena Susantitaphong, Natavudh Townamchai, Pisut Katavatin, Khajohn Tiranathanagul, Talerngsak Kanjanabuch, Yingyos Avihingsanon, Kearkiat Praditpornsilpa, Somchai Eiam-Ong

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
prevalence, renal replacement therapy, vitamin D deficiency, 25 hydroxyvitamin D