<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Tremor is one of the most common and most debilitating symptoms of Parkinson’s disease (PD). Classic pill-rolling resting tremor is characteristic of PD and distinguishes it from other neurodegenerative disorders. Although it represents the most typical and most common form of tremor in PD, other tremor manifestations have also been reported to occur in PD. In this article, we review the current clinical classification of tremor with a focus on different types of parkinsonian tremor based on the consensus statement of the Movement Disorders Society. We also provide an overview of different hypotheses on the central mechanisms of the pathophysiology of parkinsonian tremor, and provide evidence for why peripheral mechanisms may play a role in the modulation of PD tremor.</p></abstract>

Tremor is one of the most common and most debilitating symptoms of Parkinson’s disease (PD). Classic pill-rolling resting tremor is characteristic of PD and distinguishes it from other neurodegenerative disorders. Although it represents the most typical and most common form of tremor in PD, other tremor manifestations have also been reported to occur in PD. In this article, we review the current clinical classification of tremor with a focus on different types of parkinsonian tremor based on the consensus statement of the Movement Disorders Society. We also provide an overview of different hypotheses on the central mechanisms of the pathophysiology of parkinsonian tremor, and provide evidence for why peripheral mechanisms may play a role in the modulation of PD tremor.

Pathophysiology of parkinsonian tremor: a focused narrative review

Chulalongkorn Center of Excellence on Parkinson Disease and Related Disorders, Department of Medicine, Faculty of Medicine

Chulalongkorn University and King Chulalongkorn Memorial Hospital

Biomedical Signal Processing Laboratory, Department of Neurology

David Geffen School of Medicine at University of California

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Pathophysiology of parkinsonian tremor: a focused narrative review"}

Tremor is one of the most common and most debilitating symptoms of Parkinson’s disease (PD). Classic pill-rolling resting tremor is characteristic of PD and...

Pathophysiology of parkinsonian tremor: a focused narrative review

Article Category: Mini review article

Published Online: Mar 31, 2017

Page range: s15 - s22

DOI: https://doi.org/10.5372/1905-7415.1000.517

Keywords
Parkinson’s disease, pathophysiology, tremor

© 2016 Onanong Jitkritsadakul, Priya Jagota, Roongroj Bhidayasiri

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Figure 2

Pathophysiology of parkinsonian tremor: a focused narrative review

Article Category: Mini review article

Published Online: Mar 31, 2017

Page range: s15 - s22

DOI: https://doi.org/10.5372/1905-7415.1000.517

KeywordsParkinson’s disease, pathophysiology, tremor

© 2016 Onanong Jitkritsadakul, Priya Jagota, Roongroj Bhidayasiri

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Figure 2

Keywords
Parkinson’s disease, pathophysiology, tremor