<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_1905-7415.0903.407_s_001_w2aab3b7c13b1b6b1aab1c16b1Aa"><h3>Background</h3><p>Ephedrine has vasoconstrictive and mild β-adrenergic agonist effects that may be able to decrease intraoperative core temperature hypothermia. However, its efficacy is still unclear.</p></sec><sec id="j_1905-7415.0903.407_s_002_w2aab3b7c13b1b6b1aab1c16b2Aa"><h3>Objectives</h3><p>To determine the efficacy of ephedrine given during induction to maintain core temperature during plastic and breast surgery under general anesthesia.</p></sec><sec id="j_1905-7415.0903.407_s_003_w2aab3b7c13b1b6b1aab1c16b3Aa"><h3>Materials and Methods</h3><p>A prospective, randomized, double-blinded study was approved by our Institutional Review Board and registered with the Thai Clinical Trials Registry as TCTR20141212002. We randomly assigned 30 patients to receive mixture of propofol and ephedrine (ephedrine group, n = 15) or a mixture of propofol and normal saline (control group, n = 15) for induction of general anesthesia. The tympanic temperature (core temperature before intubation), esophageal temperature (core temperature after intubation), index temperature (peripheral temperature), systolic and diastolic blood pressure were compared between groups and baselines.</p></sec><sec id="j_1905-7415.0903.407_s_004_w2aab3b7c13b1b6b1aab1c16b4Aa"><h3>Results</h3><p>During surgery, patients in ephedrine group showed better esophageal temperature maintenance than those in the control group. Whereas systolic blood pressure in ephedrine group was significantly higher than in the control group in early phase after induction.</p></sec><sec id="j_1905-7415.0903.407_s_005_w2aab3b7c13b1b6b1aab1c16b5Aa"><h3>Conclusions</h3><p>A bolus dose of ephedrine given during induction can decrease core temperature loss during plastic and breast surgery under general anesthesia.</p></sec></abstract>

BackgroundEphedrine has vasoconstrictive and mild β-adrenergic agonist effects that may be able to decrease intraoperative core temperature hypothermia. However, its efficacy is still unclear.ObjectivesTo determine the efficacy of ephedrine given during induction to maintain core temperature during plastic and breast surgery under general anesthesia.Materials and MethodsA prospective, randomized, double-blinded study was approved by our Institutional Review Board and registered with the Thai Clinical Trials Registry as TCTR20141212002. We randomly assigned 30 patients to receive mixture of propofol and ephedrine (ephedrine group, n = 15) or a mixture of propofol and normal saline (control group, n = 15) for induction of general anesthesia. The tympanic temperature (core temperature before intubation), esophageal temperature (core temperature after intubation), index temperature (peripheral temperature), systolic and diastolic blood pressure were compared between groups and baselines.ResultsDuring surgery, patients in ephedrine group showed better esophageal temperature maintenance than those in the control group. Whereas systolic blood pressure in ephedrine group was significantly higher than in the control group in early phase after induction.ConclusionsA bolus dose of ephedrine given during induction can decrease core temperature loss during plastic and breast surgery under general anesthesia.

Ephedrine and propofol for induction of general anesthesia can decrease intraoperative hypothermia in patients undergoing plastic and breast surgery: a randomized, controlled trial

Department of Anesthesiology, Faculty of Medicine Ramathibodi Hospital

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

BackgroundEphedrine has vasoconstrictive and mild β-adrenergic agonist effects that may be able to decrease intraoperative core temperature hypothermia....

Ephedrine and propofol for induction of general anesthesia can decrease intraoperative hypothermia in patients undergoing plastic and breast surgery: a randomized, controlled trial

Article Category: Brief communication (Original)

Published Online: Jan 31, 2017

Page range: 379 - 385

DOI: https://doi.org/10.5372/1905-7415.0903.407

Keywords
Ephedrine, general anesthesia, hypothermia, temperature

© 2015 Thanist Pravitharangul, Wirakorn Koopinpaitoon, Rungruedee Kraisen, Rojnarin Komonhirun

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Ephedrine and propofol for induction of general anesthesia can decrease intraoperative hypothermia in patients undergoing plastic and breast surgery: a randomized, controlled trial

Article Category: Brief communication (Original)

Published Online: Jan 31, 2017

Page range: 379 - 385

DOI: https://doi.org/10.5372/1905-7415.0903.407

KeywordsEphedrine, general anesthesia, hypothermia, temperature

© 2015 Thanist Pravitharangul, Wirakorn Koopinpaitoon, Rungruedee Kraisen, Rojnarin Komonhirun

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Ephedrine, general anesthesia, hypothermia, temperature