<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_1905-7415.0902.393_s_003_w2aab3b7c16b1b6b1aab1c17b1Aa"><h3>Background</h3><p>Pituitary stalk interruption syndrome (PSIS) is characterized by a thin or interrupted pituitary stalk, impairing delivery of hypothalamic hormones to the pituitary, and anterior pituitary dysplasia.</p></sec><sec id="j_1905-7415.0902.393_s_004_w2aab3b7c16b1b6b1aab1c17b2Aa"><h3>Objectives</h3><p>To summarize the manifestations and treatment of PSIS.</p></sec><sec id="j_1905-7415.0902.393_s_005_w2aab3b7c16b1b6b1aab1c17b3Aa"><h3>Methods</h3><p>We performed a meta-analysis of PSIS research published between January 1, 2004 and December 31, 2013. Chinese databases were searched using the terms “pituitary stalk interruption syndrome”, “PSIS”, and “vertebral handle interrupts syndrome”; and results limited to clinical studies. Age of onset and diagnosis, sex, symptoms at presentation, main clinical signs, magnetic resonance imaging (MRI), laboratory results, and other data were extracted from qualifying studies.</p></sec><sec id="j_1905-7415.0902.393_s_006_w2aab3b7c16b1b6b1aab1c17b4Aa"><h3>Results</h3><p>We included 311 cases from 33 papers in the meta-analysis. The male:female ratio was 257:54, and 183 of the 311 patients had a history of abnormal birth or cerebral hypoxia. MRI showed 239 cases of missing and 62 cases of tapered pituitary stalk. Multiple pituitary hormone deficiency was identified in 190 cases, and single growth hormone deficiency in 75. There were significant associations between missing pituitary stalk and multiple pituitary hormone deficiency, and pituitary stalk tapering and single hormone deficiency (<italic>P</italic> &lt; 0.01). The clinical signs included growth retardation and the absence or delay in development of secondary sexual characteristics. Therapy was usually inadequate, with only 12 patients (3.86%) undergoing growth hormone replacement.</p></sec><sec id="j_1905-7415.0902.393_s_007_w2aab3b7c16b1b6b1aab1c17b5Aa"><h3>Conclusions</h3><p>Abnormal delivery and cerebral hypoxia may be important causes of PSIS, and MRI is valuable for its diagnosis. Measuring the levels of pituitary hormones is necessary for timely diagnosis and treatment.</p></sec></abstract>

BackgroundPituitary stalk interruption syndrome (PSIS) is characterized by a thin or interrupted pituitary stalk, impairing delivery of hypothalamic hormones to the pituitary, and anterior pituitary dysplasia.ObjectivesTo summarize the manifestations and treatment of PSIS.MethodsWe performed a meta-analysis of PSIS research published between January 1, 2004 and December 31, 2013. Chinese databases were searched using the terms “pituitary stalk interruption syndrome”, “PSIS”, and “vertebral handle interrupts syndrome”; and results limited to clinical studies. Age of onset and diagnosis, sex, symptoms at presentation, main clinical signs, magnetic resonance imaging (MRI), laboratory results, and other data were extracted from qualifying studies.ResultsWe included 311 cases from 33 papers in the meta-analysis. The male:female ratio was 257:54, and 183 of the 311 patients had a history of abnormal birth or cerebral hypoxia. MRI showed 239 cases of missing and 62 cases of tapered pituitary stalk. Multiple pituitary hormone deficiency was identified in 190 cases, and single growth hormone deficiency in 75. There were significant associations between missing pituitary stalk and multiple pituitary hormone deficiency, and pituitary stalk tapering and single hormone deficiency (P < 0.01). The clinical signs included growth retardation and the absence or delay in development of secondary sexual characteristics. Therapy was usually inadequate, with only 12 patients (3.86%) undergoing growth hormone replacement.ConclusionsAbnormal delivery and cerebral hypoxia may be important causes of PSIS, and MRI is valuable for its diagnosis. Measuring the levels of pituitary hormones is necessary for timely diagnosis and treatment.

Pituitary stalk interruption syndrome: a case report and review of the literature

Department of Endocrinology and Rheumatism

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

BackgroundPituitary stalk interruption syndrome (PSIS) is characterized by a thin or interrupted pituitary stalk, impairing delivery of hypothalamic hormones...

Pituitary stalk interruption syndrome: a case report and review of the literature

Article Category: Clinical report

Published Online: Jan 31, 2017

Page range: 237 - 243

DOI: https://doi.org/10.5372/1905-7415.0902.393

Keywords
Abnormal parturition, case report, cerebral anoxia, newborn, pituitary stalk interruption syndrome

© 2017 Yan Zhang, Changbin Quan, Weimin Li, Liying Chen, Xiaoyan Song, Jianbin Xu, Guangqing Zhu

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Pituitary stalk interruption syndrome: a case report and review of the literature

Article Category: Clinical report

Published Online: Jan 31, 2017

Page range: 237 - 243

DOI: https://doi.org/10.5372/1905-7415.0902.393

KeywordsAbnormal parturition, case report, cerebral anoxia, newborn, pituitary stalk interruption syndrome

© 2017 Yan Zhang, Changbin Quan, Weimin Li, Liying Chen, Xiaoyan Song, Jianbin Xu, Guangqing Zhu

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Abnormal parturition, case report, cerebral anoxia, newborn, pituitary stalk interruption syndrome