Study | Dose of n-3 PUFAs | Study duration (month) | Total population (treatment/control) | Number of patients with CV mortality (treatment/control) |
---|---|---|---|---|
GISSI-P | 1 gram/day | 42 | 11,324 (5,666/5,658) | 680 (310/370) |
OMEGA | 1 gram/day | 12 | 3,804 (1,919/1,885) | 57 (28/29) |
Strategy | Cost (THB) | QALY | ICER/QALY | LYG | ICER/LYG |
---|---|---|---|---|---|
No n-3 PUFAs | 2,001,572 | 13.05 | 15.48 | ||
n-3 PUFAs | 2,600,349 | 15.06 | 297,193 | 17.82 | 256,199 |
Distribution | RR | SE | References | |
---|---|---|---|---|
Effect of n-3 PUFAs on cardiovascular mortality | Gamma | 0.73 | 0.0740 | Meta-analysis |
Effect of n-3 PUFAs on nonfatal MI | Gamma | 0.91 | 0.1225 | ( |
Effect of n-3 PUFAs on nonfatal stroke | Gamma | 1.22 | 0.3138 | ( |
Effect of n-3 PUFAs on nonfatal heart failure | Gamma | 0.90 | 0.0459 | ( |
Cost of MI in the first year | Gamma | 185,143 | 11,953 | ( |
Cost of MI in the subsequent year | Gamma | 13,588 | 679 Assumption (5% of the mean), Assumption (calculated from the formula SE = SD/(8840)1/2; n = 8840, assumed SD = 1) | ( |
Cost of stroke in the first year | Gamma | 30,642 | 2,165 | ( |
Cost of stroke in the subsequent year | Gamma | 15,694 | 1,773 | ( |
Cost of heart failure in the first year | Gamma | 19,507 | 975 Assumption (5% of the mean), Assumption (calculated from the formula SE = SD/(8840)1/2; n = 8840, assumed SD = 1) | NHSO |
Cost of heart failure in the subsequent year | Gamma | 8,023 | 401 Assumption (5% of the mean), Assumption (calculated from the formula SE = SD/(8840)1/2; n = 8840, assumed SD = 1) | NHSO |
Cost of n-3 PUFAs per year | Gamma | 15,231 | 762 Assumption (5% of the mean), Assumption (calculated from the formula SE = SD/(8840)1/2; n = 8840, assumed SD = 1) | DMSIC website |
Utility of MI | Beta | 0.870 | 0.0255 | ( |
Utility of post-MI | Beta | 0.910 | 0.0255 | ( |
Utility of stroke | Beta | 0.550 | 0.0172 | ( |
Utility of post-stroke | Beta | 0.663 | 0.0106 | ( |
Utility of heart failure | Beta | 0.600 | 0.0102 | ( |
Utility of post-heart failure | Beta | 0.680 | 0.0260 | ( |
Utility of death | Beta | 0.000 | 0.0000 |