<abstract xmlns="http://www.w3.org/1999/xhtml"> Background: Pyoderma gangrenosum is a rare condition usually associated with underlying diseases such as ulcerative colitis, inflammatory bowel disease, or rheumatoid arthritis. However, some cases may also be traced to trauma or surgical procedures.Objective: We reported a patient with pyoderma gangrenosum from work-related injury with abnormal cytokine elevation.Results: Skin biopsy of the ulcer showed diffuse cellular infiltration and increased expression of granulocyte colony-stimulating factor (G-CSF). Laboratory studies revealed elevated white blood cell levels and increases in the inflammatory markers interleukin-6 (IL-6) and G-CSF. Oral doses of prednisolone were effective in treating the ulcer.Conclusion: Measuring G-CSF and IL-6 levels may help facilitate earlier diagnosis of pyoderma gangrenosum, thereby resulting in more effective treatment.</abstract>

Background: Pyoderma gangrenosum is a rare condition usually associated with underlying diseases such as ulcerative colitis, inflammatory bowel disease, or rheumatoid arthritis. However, some cases may also be traced to trauma or surgical procedures.Objective: We reported a patient with pyoderma gangrenosum from work-related injury with abnormal cytokine elevation.Results: Skin biopsy of the ulcer showed diffuse cellular infiltration and increased expression of granulocyte colony-stimulating factor (G-CSF). Laboratory studies revealed elevated white blood cell levels and increases in the inflammatory markers interleukin-6 (IL-6) and G-CSF. Oral doses of prednisolone were effective in treating the ulcer.Conclusion: Measuring G-CSF and IL-6 levels may help facilitate earlier diagnosis of pyoderma gangrenosum, thereby resulting in more effective treatment.

Clinical report. Pyoderma gangrenosum and cytokine elevation associated with work-related injury

Department of Environmental Immuno-Dermatology Yokohama City University Graduate School of Medicine, Yokohama 2360004,

Department of Dermatology, Yokohama City University Medical Center, Yokohama 2320024,

Department of Pathology, Yokohama City University Medical Center, Yokohama 2320024,

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Background: Pyoderma gangrenosum is a rare condition usually associated with underlying diseases such as ulcerative colitis, inflammatory bowel disease, or...

Clinical report. Pyoderma gangrenosum and cytokine elevation associated with work-related injury

Published Online: Feb 04, 2017

Page range: 587 - 590

DOI: https://doi.org/10.5372/1905-7415.0704.216

Keywords
Cytokines, immunosuppression, interleukins, pyoderma gangrenosum

© 2017

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Clinical report. Pyoderma gangrenosum and cytokine elevation associated with work-related injury

Published Online: Feb 04, 2017

Page range: 587 - 590

DOI: https://doi.org/10.5372/1905-7415.0704.216

KeywordsCytokines, immunosuppression, interleukins, pyoderma gangrenosum

© 2017

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
Cytokines, immunosuppression, interleukins, pyoderma gangrenosum