<abstract xmlns="http://www.w3.org/1999/xhtml"> Background: The right understanding of antibiotic susceptibility patterns is important for cost effectiveness and outcome of care of septicemic patients. Objectives: To determine antibacterial resistance patterns against commonly used therapeutic antibiotics in septicemic children of Lahore by isolating and analyzing the most frequently occurring bacterial pathogen from blood samples. Methods: Twelve hundred blood samples from children with septicemia were processed at the Lahore Identification of Bacteria Laboratory following the Clinical Laboratory Standard Institute reference 2006. Antibiotic sensitivity was analyzed using the Kirby-Bauer disc diffusion method. Results: The most effective antibiotics against the frequently isolated Klebsiella spp. were piperacillin- tazobactam (87.74%). High antimicrobial resistance was observed with cefuroxime (95.58%) and cefixime (93.38%). Conclusion: Klebsiella are the most frequently occurring bacterial pathogens from blood samples of children with septicemia. Moreover, the antibiotics to which there was most resistance belong to the cephalosporins, which are among the foremost used antibiotics in Pakistan.</abstract>

Background: The right understanding of antibiotic susceptibility patterns is important for cost effectiveness and outcome of care of septicemic patients. Objectives: To determine antibacterial resistance patterns against commonly used therapeutic antibiotics in septicemic children of Lahore by isolating and analyzing the most frequently occurring bacterial pathogen from blood samples. Methods: Twelve hundred blood samples from children with septicemia were processed at the Lahore Identification of Bacteria Laboratory following the Clinical Laboratory Standard Institute reference 2006. Antibiotic sensitivity was analyzed using the Kirby-Bauer disc diffusion method. Results: The most effective antibiotics against the frequently isolated Klebsiella spp. were piperacillin- tazobactam (87.74%). High antimicrobial resistance was observed with cefuroxime (95.58%) and cefixime (93.38%). Conclusion: Klebsiella are the most frequently occurring bacterial pathogens from blood samples of children with septicemia. Moreover, the antibiotics to which there was most resistance belong to the cephalosporins, which are among the foremost used antibiotics in Pakistan.

Organisms and antibiotic sensitivity patterns in septicemic children of Lahore, Pakistan

Division of Biochemistry, Department of Chemistry, Government College University, Lahore 54000,

Department of Microbiology, Children Hospital and Institute of Child Health, Lahore 54000,

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Background: The right understanding of antibiotic susceptibility patterns is important for cost effectiveness and outcome of care of septicemic patients....

Organisms and antibiotic sensitivity patterns in septicemic children of Lahore, Pakistan

Article Category: Brief communication (Original)

Published Online: Feb 04, 2017

Page range: 615 - 618

DOI: https://doi.org/10.5372/1905-7415.0604.099

Keywords
Antibiotic, Klebsiella species, septicemic children, Pakistan

© 2017

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Organisms and antibiotic sensitivity patterns in septicemic children of Lahore, Pakistan

Article Category: Brief communication (Original)

Published Online: Feb 04, 2017

Page range: 615 - 618

DOI: https://doi.org/10.5372/1905-7415.0604.099

KeywordsAntibiotic, Klebsiella species, septicemic children, Pakistan

© 2017

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
Antibiotic, Klebsiella species, septicemic children, Pakistan