<abstract xmlns="http://www.w3.org/1999/xhtml"> Background: Pulmonary aspergillosis may be the first presentation of chronic granulomatous disease (CGD) and may occur during infancy. Imaging studies with plain chest radiographs and computed tomography may present a diagnostic challenge, and high index of suspicion is required for the diagnosis.Objective: Report a six-week-old boy with chronic granulomatous disease and invasive pulmonary aspergillosis, in who color Doppler sonography of the chest showed systemic arterial supply to the pulmonary lesions.Methods: Sonography of the chest using a high-frequency linear transducer was performed in a six-week-old infant with chronic granulomatous disease who presented with noisy breathing, cough, and low-grade fever, and his chest radiograph revealed multiple sites of pulmonary opacities.Results: The peripheral pulmonary nodules had low-resistant arterial supply derived from a systemic artery of the chest wall. The pulmonary lesion was later proven to be fungal infection. Similar imaging was detected in another two infants with the same disease.Conclusion: Systemic arterial supply could develop to feed peripheral pulmonary aspergillosis in an infant as young as six-week old who had underling CGD.</abstract>

Background: Pulmonary aspergillosis may be the first presentation of chronic granulomatous disease (CGD) and may occur during infancy. Imaging studies with plain chest radiographs and computed tomography may present a diagnostic challenge, and high index of suspicion is required for the diagnosis.Objective: Report a six-week-old boy with chronic granulomatous disease and invasive pulmonary aspergillosis, in who color Doppler sonography of the chest showed systemic arterial supply to the pulmonary lesions.Methods: Sonography of the chest using a high-frequency linear transducer was performed in a six-week-old infant with chronic granulomatous disease who presented with noisy breathing, cough, and low-grade fever, and his chest radiograph revealed multiple sites of pulmonary opacities.Results: The peripheral pulmonary nodules had low-resistant arterial supply derived from a systemic artery of the chest wall. The pulmonary lesion was later proven to be fungal infection. Similar imaging was detected in another two infants with the same disease.Conclusion: Systemic arterial supply could develop to feed peripheral pulmonary aspergillosis in an infant as young as six-week old who had underling CGD.

Color Doppler sonography of pulmonary aspergillosis in infants with chronic granulomatous disease

MD, Department of Radiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330,

Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok 10330,

Department of Pathology Faculty of Medicine, Chulalongkorn University, Bangkok 10330,

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Background: Pulmonary aspergillosis may be the first presentation of chronic granulomatous disease (CGD) and may occur during infancy. Imaging studies with...

Color Doppler sonography of pulmonary aspergillosis in infants with chronic granulomatous disease

Article Category: Clinical report

Published Online: Feb 04, 2017

Page range: 129 - 133

DOI: https://doi.org/10.5372/1905-7415.0601.138

Keywords
Aspergillosis, child, chronic granulomatous disease, lung, ultrasound

© 2017

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Color Doppler sonography of pulmonary aspergillosis in infants with chronic granulomatous disease

Article Category: Clinical report

Published Online: Feb 04, 2017

Page range: 129 - 133

DOI: https://doi.org/10.5372/1905-7415.0601.138

KeywordsAspergillosis, child, chronic granulomatous disease, lung, ultrasound

© 2017

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
Aspergillosis, child, chronic granulomatous disease, lung, ultrasound