<abstract xmlns="http://www.w3.org/1999/xhtml"> Background: Present treatment with vasodilators usually initiated at the late stage of chronic kidney disease (CKD) fails to restore renal perfusion and function. This may be due to impaired mechanism of nitric oxide production, while the mechanism of vascular repair appears to be adequately functional in the early stage of CKD.Objective: Investigate restoration of renal perfusion and function in CKD patients by implementing vasodilators treatment at the early stage of CKD.Methods: Vasodilators treatment was implemented in 65 CKD patients (33 males and 32 females) at the early stage of CKD. The patients aged 28-71 years old, and were associated with mildly impaired renal function (mean creatinine clearance: 83±21 mL/min/1.73m2, fractional excretion of magnesium (FE Mg): 4±2% vs. normal 1.6±0.6%, total urinary protein: 85±12 mg/day, renal plasma flow (RPF): 459±59 mL/min/1.73m2, glomerlular filtration rate (GFR): 84±25 mL/min/1.73m2, peritubular capillary flow (PTCF): 332 mL/min/1.73m2). Treatment included vasodilators as follows, angiotensin converting enzyme inhibitor (ACEI) 5-20 mg/day, angiotensin II receptor blockers (ARB) 40-80 mg/day, and calcium channel blocker 5-10 mg/day for 12-24 months.Results: Following the treatment, actual creatinine clearance rose to 101±23 mL/min/1.73m2, and FE Mg and total urinary protein declined to 3±2 % and 46±7 mg/day, respectively. RPF, GFR and PTCF significantly rose to 513±90 mL/min/1.73m2, 99±33 mL/min/1.73m2 and 413±73 mL/min/1.73m2, respectively.Conclusion: Treatment with vasodilators at the early stage of CKD could restore renal perfusion and function.</abstract>

Background: Present treatment with vasodilators usually initiated at the late stage of chronic kidney disease (CKD) fails to restore renal perfusion and function. This may be due to impaired mechanism of nitric oxide production, while the mechanism of vascular repair appears to be adequately functional in the early stage of CKD.Objective: Investigate restoration of renal perfusion and function in CKD patients by implementing vasodilators treatment at the early stage of CKD.Methods: Vasodilators treatment was implemented in 65 CKD patients (33 males and 32 females) at the early stage of CKD. The patients aged 28-71 years old, and were associated with mildly impaired renal function (mean creatinine clearance: 83±21 mL/min/1.73m2, fractional excretion of magnesium (FE Mg): 4±2% vs. normal 1.6±0.6%, total urinary protein: 85±12 mg/day, renal plasma flow (RPF): 459±59 mL/min/1.73m2, glomerlular filtration rate (GFR): 84±25 mL/min/1.73m2, peritubular capillary flow (PTCF): 332 mL/min/1.73m2). Treatment included vasodilators as follows, angiotensin converting enzyme inhibitor (ACEI) 5-20 mg/day, angiotensin II receptor blockers (ARB) 40-80 mg/day, and calcium channel blocker 5-10 mg/day for 12-24 months.Results: Following the treatment, actual creatinine clearance rose to 101±23 mL/min/1.73m2, and FE Mg and total urinary protein declined to 3±2 % and 46±7 mg/day, respectively. RPF, GFR and PTCF significantly rose to 513±90 mL/min/1.73m2, 99±33 mL/min/1.73m2 and 413±73 mL/min/1.73m2, respectively.Conclusion: Treatment with vasodilators at the early stage of CKD could restore renal perfusion and function.

Restoration of renal perfusion and function in chronic kidney disease

MD, PhD, Department of Physiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330,

Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok 10330,

Department of Radiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330,

Department of Pediatrics Faculty of Medicine, Chulalongkorn University, Bangkok 10330,

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Restoration of renal perfusion and function in chronic kidney disease"}

Background: Present treatment with vasodilators usually initiated at the late stage of chronic kidney disease (CKD) fails to restore renal perfusion and...

Restoration of renal perfusion and function in chronic kidney disease

Article Category: Brief communication (Original)

Published Online: Feb 04, 2017

Page range: 95 - 98

DOI: https://doi.org/10.5372/1905-7415.0601.132

Keywords
Chronic kidney disease, creatinine clearance, FE Mg, vascular repair, vasodilators, renal hemodynamics

© 2017

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Restoration of renal perfusion and function in chronic kidney disease

Article Category: Brief communication (Original)

Published Online: Feb 04, 2017

Page range: 95 - 98

DOI: https://doi.org/10.5372/1905-7415.0601.132

KeywordsChronic kidney disease, creatinine clearance, FE Mg, vascular repair, vasodilators, renal hemodynamics

© 2017

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
Chronic kidney disease, creatinine clearance, FE Mg, vascular repair, vasodilators, renal hemodynamics