Original article. The role of p38MAPK in asymmetric dimethylarginineinduced cytoskeleton and cellular permeability changes in cultured endothelial cells

1. Vallance P, Leone A, Calver A, Collier J, Moncada S. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet .1992; 339: 572-5.10.1016/0140-6736(92)90865-ZSearch in Google Scholar

2. Cooke JP. Does ADMA cause endothelial dysfunction? Arterioscler Thromb Vasc Biol. 2000; 20:2032-7.Search in Google Scholar

3. Bogatcheva NV, Garcia JG, Verin AD. Molecular mechanisms of thrombin-induced endothelial cell permeability. Biochemistry (Mosc). 2002; 67:75-84.10.1023/A:1013904231324Search in Google Scholar

4. Jiang DJ, Jia SJ, Dai Z, Li YJ. Asymmetric dimethylarginine induces apoptosis via p38 MAPK/ caspase-3-dependent signaling pathway in endothelial cells. J Mol Cell Cardiol. 2006; 40:529-39.10.1016/j.yjmcc.2006.01.021Search in Google Scholar

5. Kayyali US, Pennella CM, Trujillo C, Villa O, Gaestel M, Hassoun PM. Cytoskeletal changes in hypoxic pulmonary endothelial cells are dependent on MAPK-activated protein kinase MK2. J Biol Chem. 2002; 277:42596-602.10.1074/jbc.M205863200Search in Google Scholar

6. Borbiev T, Birukova A, Liu F, Nurmukhambetova S, Gerthoffer WT, Garcia JG, et al. p38 MAP kinasedependent regulation of endothelial cell permeability. Am J Physiol Lung Cell Mol Physiol. 2004; 287: L911-18.10.1152/ajplung.00372.2003Search in Google Scholar

7. Maruo N, Morita I, Shirao M, Murota S. IL-6 increases endothelial permeability in vitro. Endocrinology. 1992; 131:710-4.Search in Google Scholar

8. Boger RH. Asymmetric dimethylarginine (ADMA) and cardiovascular disease: insights from prospective clinical trials. Vasc Med. 2005; 10 (Suppl 1):S19-25.10.1177/1358836X0501000101Open DOISearch in Google Scholar

9. Boger RH. The emerging role of asymmetric dimethylarginine as a novel cardiovascular risk factor. Cardiovasc Res. 2003; 59:824-33.10.1016/S0008-6363(03)00500-5Search in Google Scholar

10. Ju Y, Wang T, Li Y, Xin W, Wang S, Li J. Coxsackievirus B3 affects endothelial tight junctions: possible relationship to ZO-1 and F-actin, as well as p38 MAPK activity. Cell Biol Int. 2007; 31:1207-13.10.1016/j.cellbi.2007.04.00317544707Search in Google Scholar

11. Toshiyuki O, Glenn EB, Michael BY. Kinase pathways activated by stress: the p38MAPK pathway. Crit Care Med. 2000; 28:66-77.Search in Google Scholar