Long-term outcome of botulinum toxin injection for the treatment of chronic anal fissure: a randomized controlled trial

1. Ram E, Alper D, Stein GY, Bramnik Z, Dreznik Z. Internal anal sphincter function following lateral internal sphincterotomy for anal fissure: a long-term manometric study. Ann Surg. 2005; 242:208-11.10.1097/01.sla.0000171036.39886.faSearch in Google Scholar

2. Herzig DO, Lu KC. Anal fissure. Surg Clin North Am. 2010; 90:33-44.10.1016/j.suc.2009.09.002Search in Google Scholar

3. Nelson RL. Operative procedures for fissure in ano. Cochrane Database Syst Rev. 2010; (1):CD002199.10.1002/14651858.CD002199.pub3Search in Google Scholar

4. Arroyo A, Perez F, Serrano P, Candela F, Lacueva J, Calpena R. Surgical versus chemical (botulinum toxin) sphincterotomy for chronic anal fissure: long-term results of a prospective randomized clinical and manometric study. Am J Surg. 2005; 189:429-34.10.1016/j.amjsurg.2004.06.045Search in Google Scholar

5. Iswariah H, Stephens J, Rieger N, Rodda D, Hewett P. Randomized prospective controlled trial of lateral internal sphincterotomy versus injection of botulinum toxin for the treatment of idiopathic fissure in ano. ANZ J Surg .2005; 75:553-5.10.1111/j.1445-2197.2005.03427.xSearch in Google Scholar

6. Shao WJ, Li GC, Zhang ZK. Systematic review and meta-analysis of randomized controlled trials comparing botulinum toxin injection with lateral internal sphincterotomy for chronic anal fissure. Int J Colorectal Dis. 2009; 24:995-1000.10.1007/s00384-009-0683-5Search in Google Scholar

7. Maria G, Brisinda G. Nonoperative management of chronic anal fissure. Dis Colon Rectum. 2000; 43: 721-6.10.1007/BF02235597Search in Google Scholar

8. Truong DD, Stenner A, Reichel G. Current clinical applications of botulinum toxin. Curr Pharm Des. 2009; 15:3671-80.10.2174/138161209789271843Search in Google Scholar

9. Brisinda G, Cadeddu F, Mazzeo P, Maria G. Botulinum toxin A for the treatment of chronic anal fissure. Expert Rev Gastroenterol Hepatol. 2007; 1:219-28.10.1586/17474124.1.2.219Search in Google Scholar

10. Thornton MJ, Kennedy ML, King DW. Prospective manometric assessment of botulinum toxin and its correlation with healing of chronic anal fissure. Dis Colon Rectum. 2005; 48:1424-31.10.1007/s10350-005-0025-9Search in Google Scholar

11. Hyman N. Incontinence after lateral internal sphincterotomy: a prospective study and quality of life assessment. Dis Colon Rectum. 2004; 47:35-8.10.1007/s10350-003-0002-0Search in Google Scholar

12. Brisinda G, Albanese A, Cadeddu F, Bentivoglio AR, Mabisombi A, Marniga G, et al. Botulinum neurotoxin to treat chronic anal fissure: results of a randomized “Botox vs. Dysport” controlled trial. Aliment Pharmacol Ther. 2004; 19:695-701.10.1111/j.1365-2036.2004.01895.xSearch in Google Scholar

13. Minguez M, Herreros B, Espi A, Garcia-Granero E, Sanchiz V, Mora F, et al. Long-term follow-up (42 months) of chronic anal fissure after healing with botulinum toxin. Gastroenterology. 2002; 123:112-7.10.1053/gast.2002.34219Search in Google Scholar