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Chronic Exposure to High Doses of Bisphenol A Exhibits Significant Atrial Proarrhythmic Effects in Healthy Adult Rats

Vasile Bogdan Halatiu
Vasile Bogdan Halatiu
, 
Alkora Ioana Balan
Alkora Ioana Balan
, 
Dan Alexandru Cozac
Dan Alexandru Cozac
, 
Remus Bobarnac
Remus Bobarnac
, 
Marcel Perian
Marcel Perian
, 
Razvan Constantin Serban
Razvan Constantin Serban
 and 
Alina Scridon
Alina Scridon
   | May 05, 2022
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Article Category: Original Article
Published Online: May 05, 2022
Page range: 587 - 595
DOI: https://doi.org/10.47803/rjc.2021.31.3.587
Keywords
© 2021 Vasile Bogdan Halatiu et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.

Figure 1

Body weight in Control rats and in rats exposed to usual (BPA) and high (hBPA) bisphenol A doses for 9 weeks. Data are expressed as median and interquartile range; p-values were calculated using the Mann-Whitney test.
Body weight in Control rats and in rats exposed to usual (BPA) and high (hBPA) bisphenol A doses for 9 weeks. Data are expressed as median and interquartile range; p-values were calculated using the Mann-Whitney test.

Figure 2

Spontaneous atrial arrhythmogenicity at baseline and after transesophageal atrial burst pacing in Control and in rats exposed to usual (BPA) and high (hBPA) bisphenol A doses for 9 weeks. The figure illustrates the number of atrial premature beats (A and D), the number (B and E) and the duration (C and F) of spontaneous atrial fibrillation (AF) episodes per 24-h at baseline (upper panels – Baseline) and during the period following the in vivo transesophageal atrial pacing protocol (lower panels – Post-atrial pacing). The values are expressed as median and interquartile range; p-values refer to between-group comparisons based on the Mann-Whitney test.
Spontaneous atrial arrhythmogenicity at baseline and after transesophageal atrial burst pacing in Control and in rats exposed to usual (BPA) and high (hBPA) bisphenol A doses for 9 weeks. The figure illustrates the number of atrial premature beats (A and D), the number (B and E) and the duration (C and F) of spontaneous atrial fibrillation (AF) episodes per 24-h at baseline (upper panels – Baseline) and during the period following the in vivo transesophageal atrial pacing protocol (lower panels – Post-atrial pacing). The values are expressed as median and interquartile range; p-values refer to between-group comparisons based on the Mann-Whitney test.

Heart rate variability parameters in Control rats and in rats exposed to usual (BPA) and high (hBPA) bisphenol A doses for 9 weeks

Parameter Control (n = 7) BPA (n = 7) hBPA (n = 8) p-value Control vs. BPA p-value Control vs. hBPA
Time domain
SDNN (ms) 21.12 (15.71–22.03) 20.66 (18.93–26.77) 23.54 (21.16–28.11) 0.46 0.10
RMSSD (ms) 3.43 (3.14–4.16) 4.28 (4.13–4.71) 4.37 (4.93–5.54) 0.16 0.03
pNN5 (%) 11 (11–20) 19 (19–22) 22 (17–31) 0.14 0.04
Frequency domain
LF (ms2) 1.70 (1.68–1.91) 2.76 (2.06–3.12) 3.01 (1.21–4.73) 0.04 0.63
HF (ms2) 5.37 (4.69–5.94) 9.06 (7.89–9.97) 9.22 (7.60–11.68) 0.001 0.001
LF/HF 0.36 (0.28–0.38) 0.35 (0.25–0.37) 0.24 (0.17–0.29) 0.71 0.02

Atrial action potential parameters at baseline in Control rats and in rats exposed to usual (BPA) and high (hBPA) bisphenol A doses for 9 weeks

Parameter Control (n = 7) BPA (n = 7) hBPA (n = 8) p-value
Depolarization rate (mV/s) 26.2 (19.1–41.6) 26.0 (18.7–40.0) 21.8 (15.3–26.3) 0.39
APD50 (ms) 14.0 (12.9–19.9) 14.4 (13.9–16.7) 17.4 (15.6–23.3) 0.10
APD90 (ms) 37.4 (35.2–43.6) 37.9 (32.5–43.2) 43.4 (42.6–52.5) 0.16

Systolic blood pressure and mean 24-h heart rate in Control rats and in rats exposed to usual (BPA) and high (hBPA) bisphenol A doses for 9 weeks

Parameter Control (n = 7) BPA (n = 7) hBPA (n = 8) p-value
SBP (mmHg) 105.0 (87.5–117.5) 110.0 (100.0–127.5) 110.0 (110.0–120.0) 0.46
HR (bpm) 362.6 (348.4–406.5) 364.1 (354.9–375.6) 352.4 (347.1–364.6) 0.55
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