<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Heart rate variability (HRV) has long been associated with cardiovascular risk, especially after a myocardial infarction, but also in general. HRV reflects and is used as a surrogate for the balance between sympathetic and parasympathetic systems in modulating the cardiovascular activity. A low HRV, traditionally associated to sympathovagal imbalance, is associated with a worse cardiovascular prognosis. Deep brain stimulation (DBS) is a surgical technique used for severe cases of Parkinson's disease and other neurologic pathologies. DBS is performed in various areas of the brain and through different protocols. The claustrum, an area located between the external capsule and the insular cortex, was recently shown to be connected to Parkinson's motor symptoms. As DBS in other regions of the brain has proven non-motor effects, like influencing the HRV, we sought to document the effect of claustrum stimulation on the sympatho-vagal balance (SVB). Our preliminary data indicates that claustrum stimulation inclines the SVB toward the latter, but more studies are required to observe the long-term effects of this type of stimulation.</p>
</abstract>

Heart rate variability (HRV) has long been associated with cardiovascular risk, especially after a myocardial infarction, but also in general. HRV reflects and is used as a surrogate for the balance between sympathetic and parasympathetic systems in modulating the cardiovascular activity. A low HRV, traditionally associated to sympathovagal imbalance, is associated with a worse cardiovascular prognosis. Deep brain stimulation (DBS) is a surgical technique used for severe cases of Parkinson's disease and other neurologic pathologies. DBS is performed in various areas of the brain and through different protocols. The claustrum, an area located between the external capsule and the insular cortex, was recently shown to be connected to Parkinson's motor symptoms. As DBS in other regions of the brain has proven non-motor effects, like influencing the HRV, we sought to document the effect of claustrum stimulation on the sympatho-vagal balance (SVB). Our preliminary data indicates that claustrum stimulation inclines the SVB toward the latter, but more studies are required to observe the long-term effects of this type of stimulation.

Correlation between Heart Rate Variability and Claustrum Stimulation – Hypothesis, Experimental Studies and Future Perspectives

Division of Physiology and Neurosciences, Department of Functional Sciences

„Carol Davila” University of Medicine and Pharmacy

Department of Anesthesia and Intensive Care, Clinical Emergency Hospital of Plastic Surgery and Burns

„Elias” Emergency University Hospital, „Carol Davila” University of Medicine and Pharmacy

Romanian Journal of Cardiology

This work is licensed under the Creative Commons Attribution 4.0 International License.

Heart rate variability (HRV) has long been associated with cardiovascular risk, especially after a myocardial infarction, but also in general. HRV reflects and...

Correlation between Heart Rate Variability and Claustrum Stimulation – Hypothesis, Experimental Studies and Future Perspectives

Article Category: Original Article

Published Online: May 05, 2022

Page range: 529 - 536

DOI: https://doi.org/10.47803/rjc.2021.31.3.529

Keywords
sympatho-vagal balance, cardiovascular risk, deep brain stimulation, Parkinson's disease, orthostatic hypotension

© 2021 Bogdan Pavel et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Correlation between Heart Rate Variability and Claustrum Stimulation – Hypothesis, Experimental Studies and Future Perspectives

Article Category: Original Article

Published Online: May 05, 2022

Page range: 529 - 536

DOI: https://doi.org/10.47803/rjc.2021.31.3.529

Keywordssympatho-vagal balance, cardiovascular risk, deep brain stimulation, Parkinson's disease, orthostatic hypotension

© 2021 Bogdan Pavel et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
sympatho-vagal balance, cardiovascular risk, deep brain stimulation, Parkinson's disease, orthostatic hypotension