<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Left ventricle dysfunction is the link between the heart morphological changes and the overt heart failure. Hypertension is one of the main cardio-vascular conditions which can lead to development of left ventricle failure. The study was conducted at outpatient Clinic – Medlife, Memorial Hospital. It intended to compare NT-pro BNP and the ratio E/E’ as markers of diastolic dysfunction in hypertensive patients and normal ejection fraction (EF) and no signs or symptoms of heart failure. Both indexes proved to reflect independently diastolic dysfunction in symptomatic patients with different cardiac diseases but not in asymptomatic hypertensive patients. It was a single-center observational study recruiting 40 participants (20 F 52–70 age, and 20 M 56–67 age). Natriuretic peptides are widely accepted as biomarkers in heart failure with reduced ejection fraction. NT-pro BNP proved to be a very good means of diagnosing exercise-related left ventricular dysfunction (LVD) showing that it could unveil a subclinical LVD, especially in patient with myocardial remodeling. The main goal of this study was to compare the values of NT-pro BNP and E/E’. We have found no correlation between NT-pro BNP and E/E’, both pre-exercise and post-exercise, demonstrating that the later was not a reliable means of diagnosing LVD at effort in aymptomatic hypertensive patients.</p>
</abstract>

Left ventricle dysfunction is the link between the heart morphological changes and the overt heart failure. Hypertension is one of the main cardio-vascular conditions which can lead to development of left ventricle failure. The study was conducted at outpatient Clinic – Medlife, Memorial Hospital. It intended to compare NT-pro BNP and the ratio E/E’ as markers of diastolic dysfunction in hypertensive patients and normal ejection fraction (EF) and no signs or symptoms of heart failure. Both indexes proved to reflect independently diastolic dysfunction in symptomatic patients with different cardiac diseases but not in asymptomatic hypertensive patients. It was a single-center observational study recruiting 40 participants (20 F 52–70 age, and 20 M 56–67 age). Natriuretic peptides are widely accepted as biomarkers in heart failure with reduced ejection fraction. NT-pro BNP proved to be a very good means of diagnosing exercise-related left ventricular dysfunction (LVD) showing that it could unveil a subclinical LVD, especially in patient with myocardial remodeling. The main goal of this study was to compare the values of NT-pro BNP and E/E’. We have found no correlation between NT-pro BNP and E/E’, both pre-exercise and post-exercise, demonstrating that the later was not a reliable means of diagnosing LVD at effort in aymptomatic hypertensive patients.

NT-pro BNP versus E/E’ Ratio after ECG Treadmill Test in Asymptomatic Hypertensive Patients with Exercise-Induced Diastolic Dysfunction

„Carol Davila” University of Medicine and Pharmacy

Romanian Journal of Cardiology

This work is licensed under the Creative Commons Attribution 4.0 International License.

Left ventricle dysfunction is the link between the heart morphological changes and the overt heart failure. Hypertension is one of the main cardio-vascular...

Group 1 vs Group 2	BNP-1	BNP-2	BNP-3
BNP-1	P<00001
BNP-2		p<.00001
BNP-3			p<.00001

		BNP-1 vs E/E’rest	BNPmax vs E/E’postex	LVH vs BNPmax	LVH vs E/E’postex
Group 1	F	R=0.02p=0.93	R=0.18p=0.53	R=0.69p=0.008	R=0.44p=0.13
	M	R=0.35p=0.31	R=0.36p=0.30	R=0.76P=0.009	R=33p=0.34
Group 2	F	R=0.03p=0.938	R=−0.54p=0.20	R=0.08p=0.85	R=−0.10p=0.82
	M	R=−0.003p=0.998	R=0.68p=0.27	R=−0.38p=0.27	R=0.002p=0.994

	Peak BP	BNP-1	BNP-2	BNP-3	Mass index (gr/mp)	E/E’ preefort	E/E’ postfort
Group I 23 pts	177 – 225Mean=201Std=14	95 – 325Mean=168.43Std=57.14	113–387Mean=244.13Std=82.34	107–484Men=272.08Std=118.39	70 – 88Mean=79.21Std=5,63	5,4 – 16Mean=9.81Std=2.60	5,7–17Mean=11.00Std=3.32
Group II 17 pts	178 – 224Mean=201Std=14.6	26–190Mean=76.48Std=48.83	25–200Mean=85.64Std=49.23	39–140Mean=85.84Std=35.30	51–68Mean=59.05Std=4.42	5–13.3Mean=8.81Std=2.53	2–14Mean=8.81Std=2.79

Female/Male	BNP-1 vs BNP-2	BNP-1 vs BNP-3
Group 1	0.00004 / 0.0298	0.00018 / 0.0273
Group 2	0.472 / 0.218	0.406 / 0.148

NT-pro BNP versus E/E’ Ratio after ECG Treadmill Test in Asymptomatic Hypertensive Patients with Exercise-Induced Diastolic Dysfunction

Article Category: Original Article

Published Online: May 03, 2022

Page range: 343 - 349

DOI: https://doi.org/10.47803/rjc.2021.31.2.343

Keywords
hypertension, left ventricle ‘diastolic dysfunction, NT-pro BNP, E/E’

© 2021 Nicolae Paun et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Figure 1

Figure 2

Cross-comparing the BNPs (LVH vs no LVH)

Statistics results for correlation

Participants’ data

Statistics for BNP comparison within each Group (p values)

NT-pro BNP versus E/E’ Ratio after ECG Treadmill Test in Asymptomatic Hypertensive Patients with Exercise-Induced Diastolic Dysfunction

Article Category: Original Article

Published Online: May 03, 2022

Page range: 343 - 349

DOI: https://doi.org/10.47803/rjc.2021.31.2.343

Keywordshypertension, left ventricle ‘diastolic dysfunction, NT-pro BNP, E/E’

© 2021 Nicolae Paun et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Figure 1

Figure 2

Cross-comparing the BNPs (LVH vs no LVH)

Statistics results for correlation

Participants’ data

Statistics for BNP comparison within each Group (p values)

Keywords
hypertension, left ventricle ‘diastolic dysfunction, NT-pro BNP, E/E’