A Curious Case of Acute STEMI in a Young Patient; Things are Not Always What They Seem

1 Bhardwaj R, Kandoria A, Sharma R. Myocardial infarction in young adults-risk factors and pattern of coronary artery involvement. Niger Med J. 2014;55(1):44-7. https://doi.org/10.4103/0300-1652.128161 PMid:24970969 Search in Google Scholar

2 Zafirovska B, Otljanska M, Kedev S, Petkoska D. Risk factor distribution and long-term outcomes in young patients undergoing percutaneous coronary intervention in Macedonia. Acta Clin Croat. 2019;58(4):583-9. https://doi.org/10.20471/acc.2019.58.04.03 PMid:32595241 Search in Google Scholar

3 Egred M, Viswanathan G, Davis GK. Myocardial infarction in young adults. Postgrad Med J. 2005;81(962):741-5. https://doi.org/10.1136/pgmj.2004.027532 PMid:16344295 Search in Google Scholar

4 Bhisma MS, Pratanu I, Intan RE, Alkaff FF. Inherited thrombophilia transpires with severe coronary arterial thrombosis in wide range of age backgrounds: A report of 3 cases. Ann Med Surg (Lond). 2022;78:103730. https://doi.org/10.1016/j.amsu.2022.103730 PMid:35600193 Search in Google Scholar

5 Albagoush SA, Koya S, Chakraborty RK, Schmidt AE. Factor V Leiden mutation. National library of medicine. In: StatPearls. Treasure Island, FL: StatPearls. Available from: https://www.ncbi.nlm.nih.gov/books/NBK534802 [Last accessed on 2022 Apr 04]. Search in Google Scholar

6 Zaghloul A, Iorgoveanu C, Desai A, Balakumaran K, Chen K. Methylenetetrahydrofolate reductase polymorphism and premature coronary artery disease. Cureus. 2019;11(6):e5014. https://doi.org/10.7759/cureus.5014 PMid:31497444 Search in Google Scholar

7 Modin D, Claggett B, Sindet-Pedersen C, Lassen MC, Skaarup KG, Jensen JU, et al. Acute COVID-19 and the incidence of ischemic stroke and acute myocardial infarction. Circulation. 2020;142(21):2080-2. https://doi.org/10.1161/CIRCULATIONAHA.120.050809 PMid:33054349 Search in Google Scholar

8 Bangalore S, Sharma A, Slotwiner A, Yatskar L, Harari R, Shah B, et al. ST-Segment elevation in patients with Covid-19 - a case series. N Engl J Med. 2020;382(25):2478-80. https://doi.org/10.1056/NEJMc2009020 PMid:32302081 Search in Google Scholar

9 Bilaloglu S, Aphinyanaphongs Y, Jones S, Iturrate E, Hochman J, Berger JS. Thrombosis in hospitalized patients with COVID-19 in a New York City health system. JAMA. 2020;324(8):799-801. https://doi.org/10.1001/jama.2020.13372 PMid:32702090 Search in Google Scholar

10 Xie Y, Xu E, Bowe B, Al-Aly Z. Long-term cardiovascular outcomes of COVID-19. Nat Med. 2022;28:583-90. https://doi.org/10.1038/s41591-022-01689-3 Search in Google Scholar

11 Murray NP, Fuentealba C, Reyes E, Salazar A. Renal infarction associated with asymptomatic Covid-19 infection. Hematol Transfuse Cell Ther. 2021;43(3):353-6. https://doi.org/10.1016/j.htct.2021.03.008 PMid:34027306 Search in Google Scholar

12 Bereczky Z, Balogh L, Bagoly Z. Inherited thrombophilia and the risk of myocardial infarction: Current evidence and uncertainties. Kardiol Pol. 2019;77(4):419-29. https://doi.org/10.33963/KP.14804 PMid:31025650 Search in Google Scholar

13 Ye Z, Liu EH, Higgins JP, Keavney BD, Lowe GD, Collins R, et al. Seven haemostatic gene polymorphisms in coronary disease: Meta-analysis of 66,155 cases and 91,307 controls. Lancet. 2006;367(9511):651-8. https://doi.org/10.1016/S0140-6736(06)68263-9 PMid:16503463 Search in Google Scholar

14 Dowaidar M, Settin A. Risk of myocardial infarction related to factor V Leiden mutation: A meta-analysis. Genet Test Mol Biomarkers. 2010;14(4):493-8. https://doi.org/10.1089/gtmb.2010.0017 PMid:20642359 Search in Google Scholar

15 Chiasakul T, De Jesus E, Tong J, Chen Y, Crowther M, Garcia D, et al. Inherited thrombophilia and the risk of arterial ischemic stroke: A systematic review and meta-analysis. J Am Heart Assoc. 2019;8(9):e012877. https://doi.org/10.1161/JAHA.119.012877 PMid:31549567 Search in Google Scholar

16 Wald DS, Law M, Morris JK. Homocysteine and cardiovascular disease: Evidence on causality from a meta-analysis. BMJ. 2002;325(7374):1202. https://doi.org/10.1136/bmj.325.7374.1202 PMid:12446535 Search in Google Scholar

17 Kim RJ, Becker RC. Association between factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations and events of the arterial circulatory system: A meta-analysis of published studies. Am Heart J. 2003;146(6):948-57. https://doi.org/10.1016/S0002-8703(03)00519-2 PMid:14660985 Search in Google Scholar

18 Badulescu OV, Sirbu PD, Filip N, Bordeianu G, Cojocaru E, Budacu CC, et al. Hereditary thrombophilia in the era of COVID-19. Healthcare (Basel). 2022;10(6):993. https://doi.org/10.3390/healthcare10060993 PMid:35742044 Search in Google Scholar

19 Elbadry MI, Tawfeek A, Abdellatif MG, Salama EH, Abudeif A, Mahmoud H, et al. Unusual pattern of thrombotic events in young adult non-critically ill patients with COVID-19 may result from an undiagnosed inherited and acquired form of thrombophilia. Br J Haematol. 2022;196(4):902-22. https://doi.org/10.1111/bjh.17986 PMid:34888860 Search in Google Scholar