<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>BACKGROUND</h3>
<p>Various modalities of wound care in burn cases are offered, but there is no standard algorithm used. Paraffin gauze dressing, as one of the commonly used dressings, is considered to have many shortcomings. Resveratrol, a stilbenoid derived from plants, is reported to have a role in wound healing process; it has the potential to be one of the modalities for treating burns. This study aims to strengthen studies on the role of resveratrol in wound healing process, especially in burns compared with paraffin gauze.</p>
</sec>
<sec><h3>AIM</h3>
<p>This study conducted to prove that resveratrol gel more superior than paraffin gauze in deep partial thickness burns healing process.</p>
</sec>
<sec><h3>METHODS</h3>
<p>This research is a laboratory experimental study with a post-test only design, simple randomized, and single blind. A sample of 32 Wistar rats with deep partial thickness burns was divided into four control groups and four treatment groups. Control groups were treated using paraffin gauze. Treatment groups were treated using resveratrol gel. Group 1 of each group was assessed for epithelialization. Angiogenesis, fibroblasts, and collagen deposition was assessed on day 5 in group 2, day 14 in group 3, and day 21 in group 4.</p>
</sec>
<sec><h3>RESULTS</h3>
<p>Angiogenesis significantly higher in the treatment group than the control group on day 5 and 14 (p = 0.047 and 0.032) but not significantly different on day 21 (p = 0.107). The number of fibroblasts in the treatment group was significantly higher on day 5, 14, and 21 (p = 0.004; 0.038; and 0.005). Collagen deposition not significantly different on day 5 (p = 0.342) but significantly higher on day 14 and 21 (p = 0.048 and 0.002). The epithelialization process occurred earlier in the treatment group than in the control group (p = 0.001).</p>
</sec>
<sec><h3>CONCLUSION</h3>
<p>Topical administration of resveratrol gel accelerates the epithelialization process, which increases the number of angiogenesis, fibroblasts, and collagen deposition in deep partial thickness burns compared to paraffin gauze.</p>
</sec>
</abstract>

BACKGROUND
Various modalities of wound care in burn cases are offered, but there is no standard algorithm used. Paraffin gauze dressing, as one of the commonly used dressings, is considered to have many shortcomings. Resveratrol, a stilbenoid derived from plants, is reported to have a role in wound healing process; it has the potential to be one of the modalities for treating burns. This study aims to strengthen studies on the role of resveratrol in wound healing process, especially in burns compared with paraffin gauze.

AIM
This study conducted to prove that resveratrol gel more superior than paraffin gauze in deep partial thickness burns healing process.

METHODS
This research is a laboratory experimental study with a post-test only design, simple randomized, and single blind. A sample of 32 Wistar rats with deep partial thickness burns was divided into four control groups and four treatment groups. Control groups were treated using paraffin gauze. Treatment groups were treated using resveratrol gel. Group 1 of each group was assessed for epithelialization. Angiogenesis, fibroblasts, and collagen deposition was assessed on day 5 in group 2, day 14 in group 3, and day 21 in group 4.

RESULTS
Angiogenesis significantly higher in the treatment group than the control group on day 5 and 14 (p = 0.047 and 0.032) but not significantly different on day 21 (p = 0.107). The number of fibroblasts in the treatment group was significantly higher on day 5, 14, and 21 (p = 0.004; 0.038; and 0.005). Collagen deposition not significantly different on day 5 (p = 0.342) but significantly higher on day 14 and 21 (p = 0.048 and 0.002). The epithelialization process occurred earlier in the treatment group than in the control group (p = 0.001).

CONCLUSION
Topical administration of resveratrol gel accelerates the epithelialization process, which increases the number of angiogenesis, fibroblasts, and collagen deposition in deep partial thickness burns compared to paraffin gauze.

Comparison of Deep Partial Thickness Burns Wound Healing with Resveratrol Gel and Paraffin Gauze in Wistar Rats

Open Access Macedonian Journal of Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

BACKGROUND
Various modalities of wound care in burn cases are offered, but there is no standard algorithm used. Paraffin gauze dressing, as one of the commonly...

Comparison of Deep Partial Thickness Burns Wound Healing with Resveratrol Gel and Paraffin Gauze in Wistar Rats

Published Online: Feb 19, 2024

Page range: 29 - 33

Received: May 13, 2022

Accepted: Oct 15, 2022

DOI: https://doi.org/10.3889/oamjms.2024.10107

Keywords
Wound care, Deep partial thickness burns, Resveratrol

© 2024 Paulina Magdalena et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

Comparison of Deep Partial Thickness Burns Wound Healing with Resveratrol Gel and Paraffin Gauze in Wistar Rats

Published Online: Feb 19, 2024

Page range: 29 - 33

Received: May 13, 2022

Accepted: Oct 15, 2022

DOI: https://doi.org/10.3889/oamjms.2024.10107

KeywordsWound care, Deep partial thickness burns, Resveratrol

© 2024 Paulina Magdalena et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

Keywords
Wound care, Deep partial thickness burns, Resveratrol