<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>BACKGROUND</h3>
<p>Congenital adrenal hyperplasia (CAH) can lead to bilateral adrenal tumors. Excess adrenocorticotropic hormone is thought to play a role in the development of adrenal nodules. Here, we present a patient with a simple virilizing form of 21-hydroxylase deficiency, a married man, bilateral adrenal tumors, and 46-XX chromosomes.</p>
</sec>
<sec><h3>CASE REPORT</h3>
<p>A 39-year-old man suffered from abdominal pain and tension. Abdominal tomography showed macronodular hyperplasia in both adrenal glands, with the largest nodule reaching 4.2 cm on the left side. The patient’s old records showed that CAH had been diagnosed at the age of 11 years, but the patient was not taking any medication. The patient was treated with glucocorticoid. Despite irregular use of the treatment, the size of the nodules remained stable for 3 years, and then a significant reduction in nodule size was observed.</p>
</sec>
<sec><h3>CONCLUSION</h3>
<p>In patients with bilateral adrenal masses and incidentaloma, CAH should be considered to avoid unnecessary surgery or biopsy. A 17-hydroxyprogesterone test in a suspicious patient is a useful tool for diagnosis.</p>
</sec>
</abstract>

BACKGROUND
Congenital adrenal hyperplasia (CAH) can lead to bilateral adrenal tumors. Excess adrenocorticotropic hormone is thought to play a role in the development of adrenal nodules. Here, we present a patient with a simple virilizing form of 21-hydroxylase deficiency, a married man, bilateral adrenal tumors, and 46-XX chromosomes.

CASE REPORT
A 39-year-old man suffered from abdominal pain and tension. Abdominal tomography showed macronodular hyperplasia in both adrenal glands, with the largest nodule reaching 4.2 cm on the left side. The patient’s old records showed that CAH had been diagnosed at the age of 11 years, but the patient was not taking any medication. The patient was treated with glucocorticoid. Despite irregular use of the treatment, the size of the nodules remained stable for 3 years, and then a significant reduction in nodule size was observed.

CONCLUSION
In patients with bilateral adrenal masses and incidentaloma, CAH should be considered to avoid unnecessary surgery or biopsy. A 17-hydroxyprogesterone test in a suspicious patient is a useful tool for diagnosis.

A Case of 21-hydroxylase Deficiency with Massive Bilateral Adrenal Masses

Department of Endocrinology and Metabolic Disorders

University of Health Sciences, Antalya Training and Research Hospital

Open Access Macedonian Journal of Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

{"article-title":"A Case of 21-hydroxylase Deficiency with Massive Bilateral Adrenal Masses"}

BACKGROUND
Congenital adrenal hyperplasia (CAH) can lead to bilateral adrenal tumors. Excess adrenocorticotropic hormone is thought to play a role in the...

A Case of 21-hydroxylase Deficiency with Massive Bilateral Adrenal Masses

Published Online: Dec 25, 2023

Page range: 89 - 91

Received: Feb 07, 2023

Accepted: Mar 10, 2023

DOI: https://doi.org/10.3889/oamjms.2023.11536

Keywords
Bilateral macronodular adrenal hyperplasia, Congenital adrenal hyperplasia, 21-hydroxylase deficiency, Female hermaphrodism

© 2023 Işılay Kalan Sari et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

A Case of 21-hydroxylase Deficiency with Massive Bilateral Adrenal Masses

Published Online: Dec 25, 2023

Page range: 89 - 91

Received: Feb 07, 2023

Accepted: Mar 10, 2023

DOI: https://doi.org/10.3889/oamjms.2023.11536

KeywordsBilateral macronodular adrenal hyperplasia, Congenital adrenal hyperplasia, 21-hydroxylase deficiency, Female hermaphrodism

© 2023 Işılay Kalan Sari et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

Keywords
Bilateral macronodular adrenal hyperplasia, Congenital adrenal hyperplasia, 21-hydroxylase deficiency, Female hermaphrodism