<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>One of the most popular methods in the diagnosis of breast cancer is fine-needle biopsy without aspiration. Cell nuclei are the most important elements of cancer diagnostics based on cytological images. Therefore, the first step of successful classification of cytological images is effective automatic segmentation of cell nuclei. The aims of our study include (a) development of segmentation methods of cell nuclei based on deep learning techniques, (b) extraction of some morpho-metric, colorimetric and textural features of individual segmented nuclei, (c) based on the extracted features, construction of effective classifiers for detecting malignant or benign cases. The segmentation methods used in this paper are based on (a) fully convolutional neural networks and (b) the marker-controlled watershed algorithm. For the classification task, seven various classification methods are used. Cell nuclei segmentation achieves 90% accuracy for benign and 86% for malignant nuclei according to the F-score. The maximum accuracy of the classification reached 80.2% to 92.4%, depending on the type (malignant or benign) of cell nuclei. The classification of tumors based on cytological images is an extremely challenging task. However, the obtained results are promising, and it is possible to state that automatic diagnostic methods are competitive to manual ones.</p>
</abstract>

One of the most popular methods in the diagnosis of breast cancer is fine-needle biopsy without aspiration. Cell nuclei are the most important elements of cancer diagnostics based on cytological images. Therefore, the first step of successful classification of cytological images is effective automatic segmentation of cell nuclei. The aims of our study include (a) development of segmentation methods of cell nuclei based on deep learning techniques, (b) extraction of some morpho-metric, colorimetric and textural features of individual segmented nuclei, (c) based on the extracted features, construction of effective classifiers for detecting malignant or benign cases. The segmentation methods used in this paper are based on (a) fully convolutional neural networks and (b) the marker-controlled watershed algorithm. For the classification task, seven various classification methods are used. Cell nuclei segmentation achieves 90% accuracy for benign and 86% for malignant nuclei according to the F-score. The maximum accuracy of the classification reached 80.2% to 92.4%, depending on the type (malignant or benign) of cell nuclei. The classification of tumors based on cytological images is an extremely challenging task. However, the obtained results are promising, and it is possible to state that automatic diagnostic methods are competitive to manual ones.

Breast cancer nuclei segmentation and classification based on a deep learning approach

International Journal of Applied Mathematics and Computer Science

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

One of the most popular methods in the diagnosis of breast cancer is fine-needle biopsy without aspiration. Cell nuclei are the most important elements of...

Breast cancer nuclei segmentation and classification based on a deep learning approach

Published Online: Apr 03, 2021

Page range: 85 - 106

Received: Mar 02, 2020

Accepted: Dec 07, 2020

DOI: https://doi.org/10.34768/amcs-2021-0007

Keywords
breast cancer, nuclei segmentation, classification, image processing

© 2021 Marek Kowal et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Breast cancer nuclei segmentation and classification based on a deep learning approach

Published Online: Apr 03, 2021

Page range: 85 - 106

Received: Mar 02, 2020

Accepted: Dec 07, 2020

DOI: https://doi.org/10.34768/amcs-2021-0007

Keywordsbreast cancer, nuclei segmentation, classification, image processing

© 2021 Marek Kowal et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
breast cancer, nuclei segmentation, classification, image processing