<abstract xmlns="http://www.w3.org/1999/xhtml">
<sec id="j_jmotherandchild.20222601.d-22-00004_s_008">
<h3>Background</h3>
<p>Birth asphyxia is a common cause of perinatal morbidity, mortality.</p></sec>

<sec id="j_jmotherandchild.20222601.d-22-00004_s_009">
<h3>Objective</h3>
<p>To compare the efficacy of umbilical cord arterial blood lactate dehydrogenase (LDH) and pH as predictors of neonatal outcome in high-risk term pregnancies using receiver operating characteristic (ROC) curves.</p></sec>
<sec id="j_jmotherandchild.20222601.d-22-00004_s_010">
<h3>Material and methods</h3>
<p>Present retrospective cohort study was conducted in the rural tertiary centre of Northern India over two years (January 2017–December 2018). Neonates delivered to 300 term (≥37 – ≤42 weeks) high-risk antenatal women were enrolled after fulfilling inclusion criteria. Immediately after delivery of a newborn by any mode, the segment of the umbilical cord (10 cm) was double clamped, cut, and arterial blood samples were taken for LDH and pH and were compared with neonatal outcome. Statistical analysis was done using SPSS 22.0 software.</p></sec>
<sec id="j_jmotherandchild.20222601.d-22-00004_s_011">
<h3>Results</h3>
<p>For all 300 neonates mean ± SD values of cord blood LDH and pH were 545.19 ± 391.93 U/L and 7.13 ± 0.15, respectively. High cord blood lactate and low pH values were significantly associated with adverse neonatal outcomes including neonatal resuscitation, NICU admission, complications and early neonatal deaths (p=0.000). The sensitivity, specificity and negative predictive value of cord blood LDH in the prediction of neonatal death was 100.00%, 53.17%, 100%, and pH was 93.75%, 53.17%, 99.34%, respectively.</p></sec>
<sec id="j_jmotherandchild.20222601.d-22-00004_s_012">
<h3>Conclusion</h3>
<p>Cord blood lactate and pH help in the early prediction of neonatal outcomes, but cord blood lactate is a better predictor.</p></sec>
</abstract>

Background
Birth asphyxia is a common cause of perinatal morbidity, mortality.


Objective
To compare the efficacy of umbilical cord arterial blood lactate dehydrogenase (LDH) and pH as predictors of neonatal outcome in high-risk term pregnancies using receiver operating characteristic (ROC) curves.

Material and methods
Present retrospective cohort study was conducted in the rural tertiary centre of Northern India over two years (January 2017–December 2018). Neonates delivered to 300 term (≥37 – ≤42 weeks) high-risk antenatal women were enrolled after fulfilling inclusion criteria. Immediately after delivery of a newborn by any mode, the segment of the umbilical cord (10 cm) was double clamped, cut, and arterial blood samples were taken for LDH and pH and were compared with neonatal outcome. Statistical analysis was done using SPSS 22.0 software.

Results
For all 300 neonates mean ± SD values of cord blood LDH and pH were 545.19 ± 391.93 U/L and 7.13 ± 0.15, respectively. High cord blood lactate and low pH values were significantly associated with adverse neonatal outcomes including neonatal resuscitation, NICU admission, complications and early neonatal deaths (p=0.000). The sensitivity, specificity and negative predictive value of cord blood LDH in the prediction of neonatal death was 100.00%, 53.17%, 100%, and pH was 93.75%, 53.17%, 99.34%, respectively.

Conclusion
Cord blood lactate and pH help in the early prediction of neonatal outcomes, but cord blood lactate is a better predictor.

Umbilical cord arterial blood lactate dehydrogenase and pH as predictors of perinatal outcome in high-risk term pregnancies: A cohort study

Journal of Mother and Child

This work is licensed under the Creative Commons Attribution 4.0 International License.

Background
Birth asphyxia is a common cause of perinatal morbidity, mortality.


Objective
To compare the efficacy of umbilical cord arterial blood lactate...

Umbilical cord arterial blood lactate dehydrogenase and pH as predictors of perinatal outcome in high-risk term pregnancies: A cohort study

Article Category: Original articles

Published Online: Jul 20, 2022

Page range: 27 - 34

Received: Jan 06, 2022

Accepted: Mar 29, 2022

DOI: https://doi.org/10.34763/jmotherandchild.20222601.d-22-00004

Keywords
Birth Asphyxia, Encephalopathy, Neonate, Pregnancy Umbilical cord

© 2022 Kumar and Yadavv, published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Umbilical cord arterial blood lactate dehydrogenase and pH as predictors of perinatal outcome in high-risk term pregnancies: A cohort study

Article Category: Original articles

Published Online: Jul 20, 2022

Page range: 27 - 34

Received: Jan 06, 2022

Accepted: Mar 29, 2022

DOI: https://doi.org/10.34763/jmotherandchild.20222601.d-22-00004

KeywordsBirth Asphyxia, Encephalopathy, Neonate, Pregnancy Umbilical cord

© 2022 Kumar and Yadavv, published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
Birth Asphyxia, Encephalopathy, Neonate, Pregnancy Umbilical cord