<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Children with Down syndrome (DS) are at markedly increased risk for acute lymphoblastic leukaemia (ALL). DS is caused by trisomy of chromosome 21 affecting approximately 1 in 732 newborns in the USA. ALL is the most common cancer in children and constitutes approximately 25% of cancer diagnoses among children under the age of 15. Different protocols for treatment and management of paediatric ALL are available; however, DS children with ALL (DS-ALL) have increased risk of therapy-related toxicity compared to those without DS. Herein, we summarize the available literature on inherited predisposition for ALL, and possibilities for molecular therapy and treatment for DS-ALL patients.</p></abstract>

Children with Down syndrome (DS) are at markedly increased risk for acute lymphoblastic leukaemia (ALL). DS is caused by trisomy of chromosome 21 affecting approximately 1 in 732 newborns in the USA. ALL is the most common cancer in children and constitutes approximately 25% of cancer diagnoses among children under the age of 15. Different protocols for treatment and management of paediatric ALL are available; however, DS children with ALL (DS-ALL) have increased risk of therapy-related toxicity compared to those without DS. Herein, we summarize the available literature on inherited predisposition for ALL, and possibilities for molecular therapy and treatment for DS-ALL patients.

Suspicions regarding the genetic inheritance of acute lymphoblastic leukemia in patients with down syndrome

Faculty of Medical Sciences, Department of Pharmacy

Institut für Humangenetik, Universitätsklinikum Jena, Friedrich Schiller Universität

Journal of Mother and Child

This work is licensed under the Creative Commons Attribution 4.0 International License.

Children with Down syndrome (DS) are at markedly increased risk for acute lymphoblastic leukaemia (ALL). DS is caused by trisomy of chromosome 21 affecting...

Suspicions regarding the genetic inheritance of acute lymphoblastic leukemia in patients with down syndrome

Article Category: Review articles

Published Online: Jul 20, 2022

Page range: 104 - 110

Received: Jan 12, 2022

Accepted: Apr 05, 2022

DOI: https://doi.org/10.34763/jmotherandchild.20222601.d-22-00002

Keywords
Down syndrome (DS), acute lymphoblastic leukaemia (ALL), gene mutations, therapy

© 2022 Emir Behluli et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Suspicions regarding the genetic inheritance of acute lymphoblastic leukemia in patients with down syndrome

Article Category: Review articles

Published Online: Jul 20, 2022

Page range: 104 - 110

Received: Jan 12, 2022

Accepted: Apr 05, 2022

DOI: https://doi.org/10.34763/jmotherandchild.20222601.d-22-00002

KeywordsDown syndrome (DS), acute lymphoblastic leukaemia (ALL), gene mutations, therapy

© 2022 Emir Behluli et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
Down syndrome (DS), acute lymphoblastic leukaemia (ALL), gene mutations, therapy