<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec id="j_jmotherandchild.20202403.2013.d-20-00008_s_005">
<h3>Background</h3>
<p>Chest physiotherapy plays a crucial role in managing cystic fibrosis, especially during pulmonary exacerbations. This study evaluated the effects of adding a new airway clearance device to chest physiotherapy in subjects with cystic fibrosis hospitalised due to pulmonary exacerbations.</p>
</sec>
<sec id="j_jmotherandchild.20202403.2013.d-20-00008_s_006">
<h3>Methods</h3>
<p>This prospective open-label study was carried out at the Pediatric Cystic Fibrosis Centre in Poland between October 2017 and August 2018. Cystic fibrosis patients aged 10 to 18 years who were admitted to the hospital and required intravenous antibiotic therapy due to pulmonary exacerbations were consecutively allocated (1:1) to either chest physiotherapy alone or chest physiotherapy with a new airway clearance device (Simeox; PhysioAssist). Patients performed spirometry and multiple-breath nitrogen washout for lung clearance index assessment upon admission and prior to discharge.</p>
</sec>
<sec id="j_jmotherandchild.20202403.2013.d-20-00008_s_007">
<h3>Results</h3>
<p>Forty-eight cystic fibrosis patients were included (24 in each group). Spirometry parameters in both groups improved significantly after intravenous antibiotic therapy. A significant improvement in the maximum expiratory flow at 25% of forced vital capacity was observed only in the group with a new airway clearance device (p &lt; 0.01 vs. baseline). Trends towards a lower lung clearance index ratio were similar in both groups. No adverse events were observed in either group.</p>
</sec>
<sec id="j_jmotherandchild.20202403.2013.d-20-00008_s_008">
<h3>Conclusions</h3>
<p>Spirometry parameters increased significantly in cystic fibrosis patients treated for pulmonary exacerbations with intravenous antibiotic therapy and intensive chest physiotherapy. The new airway clearance device was safe and well tolerated when added to chest physiotherapy and may be another option for the treatment of pulmonary exacerbation in cystic fibrosis.</p>
</sec>
</abstract>

Background
Chest physiotherapy plays a crucial role in managing cystic fibrosis, especially during pulmonary exacerbations. This study evaluated the effects of adding a new airway clearance device to chest physiotherapy in subjects with cystic fibrosis hospitalised due to pulmonary exacerbations.


Methods
This prospective open-label study was carried out at the Pediatric Cystic Fibrosis Centre in Poland between October 2017 and August 2018. Cystic fibrosis patients aged 10 to 18 years who were admitted to the hospital and required intravenous antibiotic therapy due to pulmonary exacerbations were consecutively allocated (1:1) to either chest physiotherapy alone or chest physiotherapy with a new airway clearance device (Simeox; PhysioAssist). Patients performed spirometry and multiple-breath nitrogen washout for lung clearance index assessment upon admission and prior to discharge.


Results
Forty-eight cystic fibrosis patients were included (24 in each group). Spirometry parameters in both groups improved significantly after intravenous antibiotic therapy. A significant improvement in the maximum expiratory flow at 25% of forced vital capacity was observed only in the group with a new airway clearance device (p < 0.01 vs. baseline). Trends towards a lower lung clearance index ratio were similar in both groups. No adverse events were observed in either group.


Conclusions
Spirometry parameters increased significantly in cystic fibrosis patients treated for pulmonary exacerbations with intravenous antibiotic therapy and intensive chest physiotherapy. The new airway clearance device was safe and well tolerated when added to chest physiotherapy and may be another option for the treatment of pulmonary exacerbation in cystic fibrosis.

The effects of the addition of a new airway clearance device to chest physiotherapy in children with cystic fibrosis pulmonary exacerbations

Journal of Mother and Child

This work is licensed under the Creative Commons Attribution 4.0 International License.

Background
Chest physiotherapy plays a crucial role in managing cystic fibrosis, especially during pulmonary exacerbations. This study evaluated the effects of...

The effects of the addition of a new airway clearance device to chest physiotherapy in children with cystic fibrosis pulmonary exacerbations

Article Category: Original paper

Published Online: Jan 26, 2021

Page range: 16 - 24

DOI: https://doi.org/10.34763/jmotherandchild.20202403.2013.d-20-00008

Keywords
cystic fibrosis, pulmonary exacerbation, chest physiotherapy, airway clearance device, pulmonary function test, lung clearance index

© 2020 Katarzyna Walicka-Serzysko et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

The effects of the addition of a new airway clearance device to chest physiotherapy in children with cystic fibrosis pulmonary exacerbations

Article Category: Original paper

Published Online: Jan 26, 2021

Page range: 16 - 24

DOI: https://doi.org/10.34763/jmotherandchild.20202403.2013.d-20-00008

Keywordscystic fibrosis, pulmonary exacerbation, chest physiotherapy, airway clearance device, pulmonary function test, lung clearance index

© 2020 Katarzyna Walicka-Serzysko et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
cystic fibrosis, pulmonary exacerbation, chest physiotherapy, airway clearance device, pulmonary function test, lung clearance index