Impact of early glycemic variability on mortality and neurologic outcome of very low birth weight infants: Data from a continuous glucose monitoring system*
, , and | Apr 08, 2019
About this article
Article Category: Original Article/Praca Oryginalna
Published Online: Apr 08, 2019
Page range: 7 - 14
Received: Jan 15, 2019
Accepted: Feb 20, 2019
DOI: https://doi.org/10.34763/devperiodmed.20192301.0714
© 2019 Mateusz Jagła, Izabela Szymońska, Katarzyna Starzec, Przemko Kwinta, published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.
Univariate analysis of glucose disturbances associated with PVL, n=67. Tabela VI. Jednoczynnikowa analiza zależności zaburzeń glikemii i PVL, n=67.
| PVL n=6 | Non – PVL n=61 | p value | |
|---|---|---|---|
| Glucose, median (95% Cl for median) |
6.55 (5.37-7.06) | 5.95 (5.67-6.11) | 0.323t |
| Hypoglycemia <70 mg/dL, median (95% Cl for median) |
39.0 (1-107) | 32.0 (21-45) | 0.947mw |
| Hyperglycemia >150 mg/dL, median (95% Cl for median) |
158.5 (14-306) | 47 (17-109) | 0.286mw |
| SD of glucose (95% Cl) |
1.42 (1.01-1.98) | 1.23 (1.12-1.33) | 0.314t |
| CV of glucose (95% Cl) |
22.54 (17.70-28.69) | 20.37 (19.05-21.79) | 0.369t |
| MAGE (95% Cl) |
2.34 (1.81-3.03) | 1.84 (1.72-1.97) | 0.051t |
Univariate analysis of glucose disturbances associated with grade 3 or 4 IVH (severe IVH), n=74. Tabela IV. Jednoczynnikowa analiza zależności zaburzeń glikemii i krwawienia dokomorowego stopnia 3 lub 4, n=74.
| Severe IVH |
Non–severe IVH |
p value | |
|---|---|---|---|
| Glucose, median (95% Cl for median) |
5.92 (5.45-7.24) | 5.99 (5.68-6.24) | 0.885mw |
| Hypoglycemia <70 mg/dL, median (95% Cl for median) |
37 (23.28-123.60) | 32 (21.25-49.24) | 0.273mw |
| Hyperglycemia>150 mg/dL, median (95% Cl for median) |
47 (17-341) | 49 (17-118) | 0.697mw |
| SD of glucose (95% Cl) |
1.55 (1.12-2.16) | 1.23 (1.13-1.34) | 0.052t |
| CV of glucose (95% Cl) |
25.03 (19.68-31.83) | 20.32 (19.02-21.72) | 0.025t |
| MAGE (95% Cl) |
2.27 (1.79-2.88) | 1.85 (1.73-1.98) | 0.032* |
Interstitial fluid glucose concentration and glycemic variability indices in the cohort of very low birth weight infants (n=74). Tabela II. Śródtkankowe stężenie glukozy i wskaźniki zmienności glikemii w kohorcie noworodków z bardzo małą masą ciała (n=74).
| Parameter |
Value |
|---|---|
| Glucose, mean ( |
5.96 (0.71) |
| mean, SD (7+SD) |
1.24 (0.37) |
| CV, geometric mean (+/×GSD) |
21.24 (5.58) |
| MAGE, geometric mean ( |
1.89 (1.34) |
Univariate analysis of glucose disturbances associated with ROP requiring treatment, n=67. Tabela V. Jednoczynnikowa analiza zależności zaburzeń glikemii i ROP wymagającej leczenia, n=67.
| ROP n=22 | Non – ROP n=45 | P value | |
|---|---|---|---|
| Glucose, median (95% Cl for median) |
6.15 (5.96-6.68) | 5.81 (5.49-6.10) | 0.071mw |
| Hypoglycemia <70 mg/dL, median (95% Cl for median) |
32 (11.95-75.28) | 32 (20.46=54.23) | 0.898mw |
| Hyperglycemia >150 mg/dL, median (95% Cl for median) |
131 (58.81-266.9) | 24 (10.92-71.11) | 0.018mw |
| SD of glucose (95% Cl) |
1.42 (1.22-1.66) | 1.16 (1.06-1.27) | 0.019t |
| CV of glucose (95% Cl) |
22.73 (20.06-25.76) | 19.57 (18.23-21.02) | 0.026t |
| MAGE (95% Cl) |
2.08 (1.87-2.33) | 1.79 (1.65-1.94) | 0.029t |
Univariate analysis of glucose disturbances associated with death, n=74. Tabela III. Jednoczynnikowa analiza zależności zaburzeń glikemii i zgonu, n=74.
| Death |
Survivors |
p value |
|
|---|---|---|---|
| Glucose, median (95% Cl for median) |
6.01 (5.37-8.48) | 5.95 (5.67-6.19) | 0.548mw |
| Hypoglycemia <70 mg/dL, median (95% Cl for median) |
75 (22-172) | 32 (22-44) | 0.202mw |
| Hyperglycemia >150 mg/dL, median (95% Cl for median) |
119 (0.0-508) | 47 (20-112) | 0.664mw |
| SD of glucose (95% Cl) |
1.68 (0.97-2.93) | 1.23 (1.14-1.34) | 0.226w |
| CV of glucose (95% Cl) |
26.15 (17.31-39.51) | 20.43 (19.28-21.82) | 0.205w |
| MAGE (95% Cl) |
2.28 (1.49-3.47) | 1.87 (1.75-1.99) | 0.295” |
Multivariate linear regression model. Tabela VII. Wieloczynnikowa regresja logistyczna.
| B | Wald X2 | P | OR (95% Cl) | |
|---|---|---|---|---|
| ROP requiring treatment |
-0.01 |
6.53 |
0.011 |
0.98 (0.97-0.99) |
| Hosmer-Lemeshow test 0.179 | ||||
| Severe IVH |
-0.54 |
6.11 |
0.04 |
(0.38-0.87) |
| Hosmer-Lemeshow test 0.127 | ||||
Demographic and clinical characteristics of the patients. Tabela I. Charakterystyka kliniczna i demograficzna pacjentów.
| Number of patients |
74 |
|---|---|
| Birth weight, g, mean (SD) |
1066 (267) |
| Gender, male n (%) |
44 (59.5) |
| GA, wk median (IQR) |
28 (26-30) |
| CRIB II score, median (IQR) |
7(5-10) |
| Small for GA, n (%) |
6(8.1) |
| Antenatal steroids, n (%) |
47 (62.6) |
| Death before 7 DOL, n (%) |
3 (4.0) |
| Death before term-equivalent age, n (%) |
7(9.5) |