The impact of vitamin D supplementation on vitamin D level, urinary calcium excretion and bone density in patients with hypercalciuria and vitamin D deficiency − Preliminary report
, , , and | Jun 30, 2018
About this article
Published Online: Jun 30, 2018
Page range: 144 - 152
Received: Jan 30, 2018
Accepted: May 15, 2018
DOI: https://doi.org/10.34763/devperiodmed.20182202.144152
© 2018 Joanna Milart, Katarzyna Jobs, Małgorzata Tłustochowicz, Milena Pogonowska, Bolesław Kalicki, published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.
Fig. 1
Fig. 2
Fig. 3
Fig. 4
The correlation between vitamin D and calciuria before treatment and after 3, 6, 9 and 12 months of observation. Tabela II. Zależność między stężeniem witaminy D a kalciurią wyjściowo i po 3, 6, 9 i 12 miesiącach obserwacji.
| Calciuria before treatment |
Calciuria after 3 months |
Calciuria after 6 months |
Calciuria after 9 months |
Calciuri aafter 12 months |
|
| 25(OH)D |
r=0.28 |
||||
| 25(OH)D after 3 months |
r=-0.06 |
||||
| 25(OH)D |
r=-0.23 |
||||
| 25(OH)D after 9 months |
r=0.27 |
||||
| 25(OH)D after 12 months |
r=-0.32 |
||||
Mean values and range of calciuria, Ca/Creatinine ratio, 25OHD serum concentration and densitometry results according to the length of treatment. Tabela I. Wartości średnie i zakres kalciurii, współczynnika Ca/Kr, stężenia 25OHD oraz wyniki densytometrii w zależności od czasu leczenia.
| Before treatment |
After 3 months |
After 6 months |
After 9 months |
After 12 months |
Statistical significance before teratment and after 12 months (p<0.05) |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Range |
Av. |
Range |
Av. |
Range |
Av. |
Range |
Av. |
Range |
|||
| Calciuria |
4.15 | 0.17-7.44 | 3.96 | 0.79-10.2 | 3.92 | 0.93-7.6 | 4.65 | 1.83 -7.78 | 3.57 | 1.24-5.54 | 0.61 |
| Ca/Creatinine ratio |
0.22 | 0.08- 0.44 | 0.17 | 0.04-0.26 | 0.16 | 0.71-0.29 | 0.18 | 0.06-0.29 | 0.18 | 0.06-0.24 | 0.05 |
| 25(OH)D (ng/ml) | 17.8 | 6.8-31.8 | 24.7 | 11.0- 40.2 | 26.6 | 16.1-54.2 | 31.14 | 14.6-48.2 | 27.59 | 15.6-38.5 | 0.00005 |
| Densitometry (Z-score) |
(-0.730) | (-1.98)–(1.46) | (-0.850) | (-1.870)–(2.01) | 0.68 | ||||||
The relationship between vitamin D concentration and Ca/Creatinine ratio in daily urine collection before treatment and after 3, 6, 9 and 12 months of observation. Tabela III. Zależność między stężeniem witaminy D a współczynnikiem Ca/Kr z DZM wyjściowo i po 3, 6, 9 i 12 miesiącach obserwacji.
| Correlations |
|||||
|---|---|---|---|---|---|
| Ca/Creatinine |
Ca/Creatinine after |
Ca/Creatine after 6 months |
Ca/Creatinie after 9 months |
Ca/Creatinineafafter |
|
| 25(OH)D before treatment |
r=0.19 |
||||
| 25(OH)D after 3 months |
r=-0.19 |
||||
| 25(OH)D after 6 months |
r=0.22 |
||||
| 25(OH)D after 9 months |
r=-0.31 |
||||
| 25(OH)D after 12 months |
r=0.15 |
||||
The relationship between 25 (OH) D serum concentration and Z score in densitometry before treatment and after 12 months of follow-up.Tabela IV. Zależność między stężeniem 25(OH)D a współczynnikiem Z score w densytometrii wyjściowo i po 12 miesiącach obserwacji.
| Correlations Indicated correlation coefficients are significant with p<0.05 |
||
|---|---|---|
| Densitometry 1 |
Densitometry 2 |
|
| 25(OH)D |
r=0.15 |
|
| 25(OH)D |
r=0.23 |
|