Usefulness of measurement of nitric oxide in exhaled air in diagnostics and treatment of allergic rhinitis and asthma in children and adolescents

1Kroncke KD, Fehsel K, Kolb-Bachofen W. Inducible nitric oxide synthase and its product nitric oxide, a small molecule with complex biological activities. Biol Chem. 1995;376:327343.Kroncke KD Fehsel K Kolb-Bachofen W Inducible nitric oxide synthase and its product nitric oxide, a small molecule with complex biological activities Biol Chem 199537632734310.1002/chin.199542304Search in Google Scholar

2Baumert M. Tlenek azotu − lekarz czy zabójca? Wiad Lek. 2005;58:421-424.Baumert M Tlenek azotu − lekarz czy zabójca? Wiad Lek 200558421 424Search in Google Scholar

3Klink M, Cedzyński M. Tlenek azotu jako regulator niektórych funkcji układu odpornościowego. Postępy Biologii Komórki 1999;26:775-780.Klink M Cedzyński M. Tlenek azotu jako regulator niektórych funkcji układu odpornościowego. Postępy Biologii Komórki 199926775 780Search in Google Scholar

4Scadding G, Scadding GK. Update on the use of nitric oxide as a non-invasive measure of airways inflammation. Rhinology 2009;47:115-120.Scadding G Scadding GK Update on the use of nitric oxide as a non-invasive measure of airways inflammation Rhinology 200947115 120Search in Google Scholar

5Geller DA, Billiar TR. Molecular biology of nitric oxide synthases. Cancer Metastasis Rev. 1998;17: 7-23.Geller DA Billiar TR Molecular biology of nitric oxide synthases Cancer Metastasis Rev 199817 7 2310.1023/A:1005940202801Search in Google Scholar

6Alving K, Weitzberg E, Lundberg M. Increased amount of nitric oxide in exhaled air of asthmatics. Eur Respir J. 1993;6:1368-1370.Alving K Weitzberg E Lundberg M Increased amount of nitric oxide in exhaled air of asthmatics Eur Respir J 199361368 1370Search in Google Scholar

7Nathan C, Xie QW. Nitric oxide synthases: roles, tolls, and controls. Cell 1994;78:915-918.Nathan C Xie QW Nitric oxide synthases: roles, tolls, and controls Cell 199478915 91810.1016/0092-8674(94)90266-6Search in Google Scholar

8Dweik RA, Comhair SA, Gaston B, Thunnissen FB, Farver C, Thomassen MJ, Kavuru M, Hammel J, Abu-Soud HM, Erzurum SC. NO chemical events in the human airway during the immediate and late antigen-induced asthmatic response. Proc Natl Acad Sci. USA 2001;98:2622-2627.Dweik RA Comhair SA Gaston B Thunnissen FB Farver C Thomassen MJ Kavuru M Hammel J Abu-Soud HM Erzurum SC NO chemical events in the human airway during the immediate and late antigen-induced asthmatic response Proc Natl Acad Sci. USA 2001982622 262710.1073/pnas.0516294983018811226289Search in Google Scholar

9De Sanctis GT, MacLean JA, Hamada K, Mehta S, Scott JA, Jiao A, Yandava CN, Kobzik L, Wolyniec WW, Fabian AJ, Venugopal CS, Grasemann H,. Huang PL, and Drazen MD. Contribution of nitric oxide synthases 1, 2, and 3 to airway hyperresponsiveness and inflammation in a murine model of asthma. J Exp Med. 1999;189:1621-1630.De Sanctis GT MacLean JA Hamada K Mehta S Scott JA Jiao A Yandava CN Kobzik L Wolyniec WW Fabian AJ Venugopal CS Grasemann HHuang PL Drazen MD Contribution of nitric oxide synthases 1, 2, and 3 to airway hyperresponsiveness and inflammation in a murine model of asthma J Exp Med 19991891621 163010.1084/jem.189.10.1621219363010330441Search in Google Scholar

10Nussler AK, Billiar TR. Inflammation, immunoregulation and inducible nitric oxide synthase. J Leukoc Biol. 1993;54:171-178Nussler AK Billiar TR Inflammation, immunoregulation and inducible nitric oxide synthase J Leukoc Biol 199354171 17810.1002/jlb.54.2.171Search in Google Scholar

11American Thoriac Society Documents (ATS/ERS), Recommendations for Standardized Procedures for the Online and Offline Measurement of Exhaled Lower Respiratory Nitric Oxide and Nasal Nitric Oxide, 2005. Am J Respir Crit Care Med. 2005 Apr 15; 171:912-930American Thoriac Society Documents (ATS/ERS), Recommendations for Standardized Procedures for the Online and Offline Measurement of Exhaled Lower Respiratory Nitric Oxide and Nasal Nitric Oxide, 2005 Am J Respir Crit Care Med 2005 Apr 15 171912 93010.1164/rccm.200406-710ST15817806Search in Google Scholar

12American Thoriac Society Documents (ATS), An Official ATS Clinical Practice Guideline: Interpretation of Exhaled Nitric Oxide Levels (FeNO) for Clinical Applications, 2011. Am J Respir Crit Care Med. 2011 Sep 1; 184:602-615.American Thoriac Society Documents (ATS), An Official ATS Clinical Practice Guideline: Interpretation of Exhaled Nitric Oxide Levels (FeNO) for Clinical Applications, 2011 Am J Respir Crit Care Med 2011 Sep 1 184602 61510.1164/rccm.9120-11ST440872421885636Search in Google Scholar

132017 GINA Report, Global Strategy for Astma Management and Prevention. http://ginasthma.org/GINA Report, Global Strategy for Astma Management and Prevention http://ginasthma.org/Search in Google Scholar

14Singer F, Luchsinger I, Inci D, Knauer N, Latzin P, Wildhaber JH, Moeller A.. Exhaled nitric oxide in symptomatic children at preschool age predicts later asthma. Allergy 2013 Apr;68(4):531-538.Singer F Luchsinger I Inci D Knauer N Latzin P Wildhaber JH Moeller A. Exhaled nitric oxide in symptomatic children at preschool age predicts later asthma Allergy 2013 Apr684531 53810.1111/all.1212723414302Search in Google Scholar

15Bjermer L, Kjell A, Diamant Z, Magnussen H, Pavord I, Piacentini G, Price D, Roche N, Sastre J, Thomas M, Usmani O. Current evidence and future research needs of FeNO measurement in respiratory diseases. Respiratory Medicine 2014;108:830-841.Bjermer L Kjell A Diamant Z Magnussen H Pavord I Piacentini G Price D Roche N Sastre J Thomas M Usmani O Current evidence and future research needs of FeNO measurement in respiratory diseases Respiratory Medicine 2014108830 84110.1016/j.rmed.2014.02.00524636813Search in Google Scholar

16Mahr TA, Malka J, Spahn JD. Inflammometry in pediatric asthma: a review of fractional exhaled nitric oxide in clinical practice. Allergy Asthma Proc. 2013;34:210-219.Mahr TA Malka J Spahn JD Inflammometry in pediatric asthma: a review of fractional exhaled nitric oxide in clinical practice Allergy Asthma Proc 201334210 21910.2500/aap.2013.34.366023462278Search in Google Scholar

17Alving K, Malinovschi A.Basic aspects of exhaled nitric oxide. Eur. Respir. Mongraph. 2010;49:1-31.Alving K Malinovschi ABasic aspects of exhaled nitric oxide Eur. Respir. Mongraph 2010491 3110.1183/1025448x.00028509Search in Google Scholar

18Hanania NA, Wenzel S, Rosén K, Hsieh HJ, Mosesova S, Choy DF, Lal P, Arron JR, Harris JM, Busse W. Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study. Am J Respir Crit Care Med. 2013 Apr 15;187(8):804-811.Hanania NA Wenzel S Rosén K Hsieh HJ Mosesova S Choy DF Lal P Arron JR Harris JM Busse W Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study Am J Respir Crit Care Med 2013 Apr 151878804 81110.1164/rccm.201208-1414OC23471469Search in Google Scholar

19Neelamegan R, Saka V, Tamilarasu K, Rajaram M, Selvarajan S, Chandrasekaran A. Clinical Utility of Fractional exhaled Nitric Oxide (FeNO) as a Biomarker to Predict Severity of Disease and Response to Inhaled Corticosteroid (ICS) in Asthma Patients. J Clin Diagn Res. 2016;10:FC01-FC06.Neelamegan R Saka V Tamilarasu K Rajaram M Selvarajan S Chandrasekaran A Clinical Utility of Fractional exhaled Nitric Oxide (FeNO) as a Biomarker to Predict Severity of Disease and Response to Inhaled Corticosteroid (ICS) in Asthma Patients J Clin Diagn Res 201610FC01 FC0610.7860/JCDR/2016/20656.8950529644428208871Search in Google Scholar

20Zeiger RS, Schatz M, Zhang F, Crawford WW, Kaplan MS, Roth RM, Chen W. Elevated exhaled nitric oxide is a clinical indicator of future uncontrolled asthma in asthmatic patients on inhaled corticosteroids. J Allergy Clin Immunol. 2011 Aug;128(2):412-414.Zeiger RS Schatz M Zhang F Crawford WW Kaplan MS Roth RM Chen W Elevated exhaled nitric oxide is a clinical indicator of future uncontrolled asthma in asthmatic patients on inhaled corticosteroids J Allergy Clin Immunol 2011 Aug1282412 41410.1016/j.jaci.2011.06.00821807253Search in Google Scholar

21Liu D, Huang Z, Huang Y. Clinical Analysis of Fractional Exhaled and Nasal Nitric Oxide in Allergic Rhinitis Children. J Allergy Ther. 2015;6:204.Liu D Huang Z Huang Y Clinical Analysis of Fractional Exhaled and Nasal Nitric Oxide in Allergic Rhinitis Children J Allergy Ther 20156204Search in Google Scholar

22Lee KJ, Cho SH, Lee S, Tae K, Yoon HJ, Kim SH and Jeong JH. Nasal and exhaled nitric oxide in allergic rhinitis. J Clin Exp Otorhinolaryngol .2012;5:228-233.Lee KJ Cho SH Lee S Tae K Yoon HJ Kim SH Jeong JH. Nasal and exhaled nitric oxide in allergic rhinitis J Clin Exp Otorhinolaryngol 20125228 23310.3342/ceo.2012.5.4.228350677523205229Search in Google Scholar

23Ziętkowski Z, Bodzenta-Łukaszyk A, Tomasiak MM. Tlenek azotu w powietrzu wydychanym u chorych na alergiczny sezonowy nieżyt nosa. Alergia Astma Immunologia 2004,9:93-98.Ziętkowski Z Bodzenta-Łukaszyk A Tomasiak MM Tlenek azotu w powietrzu wydychanym u chorych na alergiczny sezonowy nieżyt nosa Alergia Astma Immunologia 2004993 98Search in Google Scholar

24Yoon J, Choi YJ, Lee E, Yang SI, Kim YH, Jung YH, Seo JH, Kwon JW, Kim HB, Lee SY, Kim BS, Shim JY, Kim EJ, Lee JS, Hong SJ1. Allergic Rhinitis in Preschool Children and the Clinical Utility of FeNO. Allergy Asthma Immunol Res. 2017 Jul;9(4):314-321.Yoon J Choi YJ Lee E Yang SI Kim YH Jung YH Seo JH Kwon JW Kim HB Lee SY Kim BS Shim JY Kim EJ Lee JS Hong SJ1 Allergic Rhinitis in Preschool Children and the Clinical Utility of FeNO Allergy Asthma Immunol Res 2017 Jul94314 32110.4168/aair.2017.9.4.314544694628497918Search in Google Scholar

25Ciprandi G, Gallo F, Ricciardolo FL, Cirillo I. Fractional Exhaled Nitric Oxide: A Potential Biomarker in Allergic Rhinitis? Int Arch Allergy Immunol. 2017;172(2):99-105.Ciprandi G Gallo F Ricciardolo FL Cirillo I Fractional Exhaled Nitric Oxide: A Potential Biomarker in Allergic Rhinitis? Int Arch Allergy Immunol 2017172299 10510.1159/00045654828253520Search in Google Scholar

26Texereau J, Marullo S, Hubert D, Coste J, Dusser DJ, Dall’Ava-Santucci J, Dinh-Xuan AT. Nitric oxide synthase 1 as a potential modifier gene of decline in lung function in patients with cystic fibrosis. Thorax. 2004 Feb;59(2):156-158.Texereau J Marullo S Hubert D Coste J Dusser DJ Dall’Ava-Santucci J Dinh-Xuan AT Nitric oxide synthase 1 as a potential modifier gene of decline in lung function in patients with cystic fibrosis Thorax 2004 Feb592156 15810.1136/thorax.2003.006718174692114760158Search in Google Scholar

27Moeller A, Horak F Jr, Lane C, Knight D, Kicic A, Brennan S, Franklin P, Terpolilli J, Wildhaber JH, and Stick SM. Inducible NO synthase expression is low in airway epithelium from young children with cystic fibrosis. Thorax. 2006 Jun;61(6):514-520.Moeller A Horak FJr Lane C Knight D Kicic A Brennan S Franklin P Terpolilli J Wildhaber JH Stick SM. Inducible NO synthase expression is low in airway epithelium from young children with cystic fibrosis Thorax 2006 Jun616514 52010.1136/thx.2005.054643211121716517573Search in Google Scholar

28Chapman AL, Morrissey BM, Vasu VT, Juarez MM, Houghton JS, Li CS, Cross CE, Eiserich JP. Myeloperoxidase-dependent oxidative metabolism of nitric oxide in the cystic fibrosis airway. J Cyst Fibros. 2010 Mar;9(2):84-92.Chapman AL Morrissey BM Vasu VT Juarez MM Houghton JS Li CS Cross CE Eiserich JP Myeloperoxidase-dependent oxidative metabolism of nitric oxide in the cystic fibrosis airway J Cyst Fibros 2010 Mar9284 9210.1016/j.jcf.2009.10.001Search in Google Scholar

29Walker WT, Jackson CL, Lackie PM, Hogg C, Lucas JS. Nitric oxide in primary ciliary dyskinesia. European Respiratory Journal 2012 ;40:1024-1032.Walker WT Jackson CL Lackie PM Hogg C Lucas JS Nitric oxide in primary ciliary dyskinesia European Respiratory Journal 2012 401024 103210.1183/09031936.00176111Search in Google Scholar

30de Gouw HW, Grünberg K, Schot R, Kroes AC, Dick EC, Sterk PJ. Relationship between exhaled nitric oxide and airway hyperresponsiveness following experimental rhinovirus infection in asthmatic subjects. Eur Respir J. 1998 Jan;11(1):126-312.de Gouw HW Grünberg K Schot R Kroes AC Dick EC Sterk PJ Relationship between exhaled nitric oxide and airway hyperresponsiveness following experimental rhinovirus infection in asthmatic subjects Eur Respir J 1998 Jan111126 31210.1183/09031936.98.11010126Search in Google Scholar

31Sanders SP, Proud D, Permutt S, Siekierski ES, Yachechko R, Liu MC. Role of nasal nitric oxide in the resolution of experimental rhinovirus infection. J Allergy Clin Immunol. 2004 Apr;113(4):697-702.Sanders SP Proud D Permutt S Siekierski ES Yachechko R Liu MC Role of nasal nitric oxide in the resolution of experimental rhinovirus infection J Allergy Clin Immunol 2004 Apr1134697 70210.1016/j.jaci.2004.01.755Search in Google Scholar

32Gadish T, Soferman R, Merimovitch T, Fireman E, Sivan Y. Exhaled nitric oxide in acute respiratory syncytial virus bronchiolitis. Arch Pediatr Adolesc Med. 2010 Aug;164(8):727-731.Gadish T Soferman R Merimovitch T Fireman E Sivan Y Exhaled nitric oxide in acute respiratory syncytial virus bronchiolitis Arch Pediatr Adolesc Med 2010 Aug1648727 73110.1001/archpediatrics.2010.128Search in Google Scholar

33Murphy AW, Platts-Mills TA, Lobo M, Hayden F. Respiratory nitric oxide levels in experimental human influenza. Chest. 1998 Aug;114(2):452-456.Murphy AW Platts-Mills TA Lobo M Hayden F Respiratory nitric oxide levels in experimental human influenza Chest 1998 Aug1142452 45610.1378/chest.114.2.452Search in Google Scholar

34Baraldi E, Bonetto G, Zacchello F, Filippone M. Low exhaled nitric oxide in school-age children with bronchopulmonary dysplasia and airflow limitation. Am J Respir Crit Care Med. 2005 Jan 1;171(1):68-72.Baraldi E Bonetto G Zacchello F Filippone M Low exhaled nitric oxide in school-age children with bronchopulmonary dysplasia and airflow limitation Am J Respir Crit Care Med 2005 Jan 1171168 7210.1164/rccm.200403-298OCSearch in Google Scholar

35Qing M, Wei X, Zhen L, Hui G, Xiao-Ying L, Hui-Jie H, Yan W, Yi-Xin R, Yong-Ge L, Li X. Influence of sensitization patterns on fractional exhaled nitric oxide in asthmatic children. Iran J Allergy Asthma Immunol. 2017;16:53-59.Qing M Wei X Zhen L Hui G Xiao-Ying L Hui-Jie H Yan W Yi-Xin R Yong-Ge L Li X Influence of sensitization patterns on fractional exhaled nitric oxide in asthmatic children Iran J Allergy Asthma Immunol 20171653 59Search in Google Scholar

36Gut G, Ben-Tov A, Lahad A, Soferman R, Cohen S, Tauman R, Sivan Y. Pulmonary functions in children with inflammatory bowel disease. Eur J Gastroenterol Hepatol. 2016 Jun;28(6):708-713.Gut G Ben-Tov A Lahad A Soferman R Cohen S Tauman R Sivan Y Pulmonary functions in children with inflammatory bowel disease Eur J Gastroenterol Hepatol 2016 Jun286708 71310.1097/MEG.0000000000000606Search in Google Scholar

37Ikonomi E, Rothstein RD, Ehrlich AC, Friedenberg FK. Measurement of Fractional Exhaled Nitric Oxide as a Marker of Disease Activity in Inflammatory Bowel Disease. J Gastroenterol Pancreatol Liver Disord. 2016;3(1).Ikonomi E Rothstein RD Ehrlich AC Friedenberg FK Measurement of Fractional Exhaled Nitric Oxide as a Marker of Disease Activity in Inflammatory Bowel Disease J Gastroenterol Pancreatol Liver Disord 20163110.15226/2374-815X/3/1/00146Search in Google Scholar

38Persson MG, Zetterström O, Agrenius V, Ihre E, Gustafsson LE. Single-breath nitric oxide measurements in asthmatic patients and smokers. Lancet 1994 Jan 15;343(8890):146-147.Persson MG Zetterström O Agrenius V Ihre E Gustafsson LE Single-breath nitric oxide measurements in asthmatic patients and smokers Lancet 1994 Jan 153438890146 14710.1016/S0140-6736(94)90935-0Search in Google Scholar

39Bjermer L, Alving K, Diamant Z, Magnussen H, Pavord I, Piacentini G, Price D, Roche N, Sastre J, Thomas M, Usmani O. Current evidence and future research needs for FeNO measurement in respiratory diseases. Respir Med. 2014 Jun;108(6):830-841.Bjermer L Alving K Diamant Z Magnussen H Pavord I Piacentini G Price D Roche N Sastre J Thomas M Usmani O Current evidence and future research needs for FeNO measurement in respiratory diseases Respir Med 2014 Jun1086830 84110.1016/j.rmed.2014.02.005Search in Google Scholar

40Majid H, Kao C. Utility of exhaled nitric oxide in the diagnosis and management of asthma. Curr Opin Pulm Med. 2010;16:42-47.Majid H Kao C Utility of exhaled nitric oxide in the diagnosis and management of asthma Curr Opin Pulm Med 20101642 4710.1097/MCP.0b013e328332ca46Search in Google Scholar

41Kłak A, Krzych-Fałta E, Samoliński B. Rola tlenku azotu w stanie zapalnym dróg oddechowych. Alergia Astma Immunologia 2013;18:91-96.Kłak A Krzych-Fałta E Samoliński B Rola tlenku azotu w stanie zapalnym dróg oddechowych Alergia Astma Immunologia 20131891 96Search in Google Scholar

42Polskie Towarzystwo Ftyzjopneumonologiczne, Zalecenia Polskiego Towarzystwa Ftyzjopneumonologicznego dotyczące wykonywania badań spirometrycznych, 2004. Pneumonol Alergol Pol 2004;72, Supp. II.Polskie Towarzystwo Ftyzjopneumonologiczne, Zalecenia Polskiego Towarzystwa Ftyzjopneumonologicznego dotyczące wykonywania badań spirometrycznych, 2004 Pneumonol Alergol Pol 200472 Supp IISearch in Google Scholar

43Lee YC, Cheon KT, Lee HB, Kim W, Rhee YK, Kim DS. Gene polymorphisms of endothelial nitric oxide synthase and angiotensin-converting enzyme in patients with asthma. Allergy 2000;55:959-963.Lee YC Cheon KT Lee HB Kim W Rhee YK Kim DS Gene polymorphisms of endothelial nitric oxide synthase and angiotensin-converting enzyme in patients with asthma Allergy 200055959 96310.1034/j.1398-9995.2000.00724.xSearch in Google Scholar

44Bouzigon E, Monier F, Boussaha M, et al. Associations between Nitric Oxide Synthase Genes and Exhaled NO-Related Phenotypes according to Asthma Status. PLoS One. 2012;7:e36672.Bouzigon E Monier F Boussaha M et al Associations between Nitric Oxide Synthase Genes and Exhaled NO-Related Phenotypes according to Asthma Status PLoS One 20127e3667210.1371/journal.pone.0036672Search in Google Scholar

45Iordanidou M, Paraskakis E, Tavridou A, et al. Endothelial nitric oxide synthase gene polymorphisms are associated with sensitization to seasonal aeroallergens in asthmatic children. World J Pediatr. 2017;13:34-40.Iordanidou M Paraskakis E Tavridou A et al Endothelial nitric oxide synthase gene polymorphisms are associated with sensitization to seasonal aeroallergens in asthmatic children World J Pediatr 20171334 4010.1007/s12519-016-0043-9Search in Google Scholar

46Stokes KY, Cooper D, Tailor A, Granger DN. Hypercholesterolemia promotes inflammation and microvascular dysfunction: role of nitric oxide and superoxide. Free Radic Biol Med. 2002;33:1026-1036.Stokes KY Cooper D Tailor A Granger DN Hypercholesterolemia promotes inflammation and microvascular dysfunction: role of nitric oxide and superoxide Free Radic Biol Med 2002331026 103610.1016/S0891-5849(02)01015-8Search in Google Scholar

47Baumruker T, Csonga R, Pursch E, Pfeffer A, Urtz N, Sutton S, Bofill-Cardona E, Cooke M, Prieschl E. Activation of mast cells by incorporation of cholesterol into rafis. Int Immunol. 2003;15:1207-1218.Baumruker T Csonga R Pursch E Pfeffer A Urtz N Sutton S Bofill-Cardona E Cooke M Prieschl E Activation of mast cells by incorporation of cholesterol into rafis Int Immunol 2003151207 121810.1093/intimm/dxg12013679390Search in Google Scholar

48Robertson AK, Zhou X, Strandvik B, Hansson GK. Severe hypercholesterolaemia leads to strong TH2 responses to an exogenous antigen. Scand J Immunol. 2004;59:285-293.Robertson AK Zhou X Strandvik B Hansson GK Severe hypercholesterolaemia leads to strong TH2 responses to an exogenous antigen Scand J Immunol 200459285 29310.1111/j.0300-9475.2004.01403.x15030580Search in Google Scholar

49Kim SY, Sim S, Park B, Kim JH, Choi HG3. High-Fat and Low-Carbohydrate Diets Are Associated with Allergic Rhinitis But Not Asthma or Atopic Dermatitis in Children. PLoS One. 2016 Feb 26;11(2):e0150202.Kim SY Sim S Park B Kim JH Choi HG3 High-Fat and Low-Carbohydrate Diets Are Associated with Allergic Rhinitis But Not Asthma or Atopic Dermatitis in Children PLoS One 2016 Feb 26112e015020210.1371/journal.pone.0150202476927526919190Search in Google Scholar

50Lei Y, Yang H, Zhen L. Obesity is a risk factor for allergic rhinitis in children of Wuhan (China). Asia Pac Allergy. 2016 Apr;6(2):101-104.Lei Y Yang H Zhen L Obesity is a risk factor for allergic rhinitis in children of Wuhan (China) Asia Pac Allergy 2016 Apr62101 10410.5415/apallergy.2016.6.2.101485033227141483Search in Google Scholar

51Vinding RK, Stokholm J, Chawes BLK, Bisgaard H. Blood lipid levels associate with childhood asthma, airway obstruction, bronchial hyperresponsiveness, and aeroallergen sensitization. J Allergy Clin Immunol. 2016;137:68-74.Vinding RK Stokholm J Chawes BLK Bisgaard H Blood lipid levels associate with childhood asthma, airway obstruction, bronchial hyperresponsiveness, and aeroallergen sensitization J Allergy Clin Immunol 201613768 7410.1016/j.jaci.2015.05.03326148797Search in Google Scholar

52Berg CM, Thelle DS, Rosengren A, Lissner L, Torén K, Olin AC. Decreased fraction of exhaled nitric oxide in obese subjects with asthma symptoms: data from the population study INTERGENE/ADONIX. Chest. 2011 May;139(5):1109-1116.Berg CM Thelle DS Rosengren A Lissner L Torén K Olin AC Decreased fraction of exhaled nitric oxide in obese subjects with asthma symptoms: data from the population study INTERGENE/ADONIX Chest 2011 May13951109 111610.1378/chest.10-129921183611Search in Google Scholar

53Yao TC, Tsai HJ, Chang SW, et al. Obesity disproportionately impacts lung volumes, airflow and exhaled nitric oxide in children. PLoS One. 2017;12: e0174691.Yao TC Tsai HJ Chang SW et al Obesity disproportionately impacts lung volumes, airflow and exhaled nitric oxide in children PLoS One 201712 e017469110.1371/journal.pone.0174691538033728376119Search in Google Scholar

54Han YY, Forno E, Celedón JC. Adiposity, fractional exhaled nitric oxide, and asthma in U.S. children. Am J Respir Crit Care Med. 2014;190:32-39.Han YY Forno E Celedón JC Adiposity, fractional exhaled nitric oxide, and asthma in U.S. children Am J Respir Crit Care Med 201419032 3910.1164/rccm.201403-0565OC422603124922361Search in Google Scholar

55Haight JS, Djupesland PG, Qjan W, Chatkin JM, Furlott H, Irish J, Witterick I, McClean P, Fenton RS, Hoffstein V, Zamel N. Does nasal nitric oxide come from the sinuses? J Otolaryngol. 1999;28:197-204.Haight JS Djupesland PG Qjan W Chatkin JM Furlott H Irish J Witterick I McClean P Fenton RS Hoffstein V Zamel N Does nasal nitric oxide come from the sinuses? J Otolaryngol 199928197 204Search in Google Scholar

56Lundberg JO, Rinder J, Weitzberg E, Lundberg JM, Alving K. Nasally exhaled nitric oxide in humans originates mainly in the paranasal sinuses. Acta Physiol Scand. 1994;152: 431-432.Lundberg JO Rinder J Weitzberg E Lundberg JM Alving K Nasally exhaled nitric oxide in humans originates mainly in the paranasal sinuses Acta Physiol Scand 1994152 431 43210.1111/j.1748-1716.1994.tb09826.x7701944Search in Google Scholar

57Struben VMD, Wieringa MH, Mantingh CJ, Bommeljé C, Don M, Feenstra L, de Jongste JC. Nasal NO: normal values in children age 6 through to 17 years. Eur Respir J. 2005;26: 453-457.Struben VMD Wieringa MH Mantingh CJ Bommeljé C Don M Feenstra L de Jongste JC Nasal NO: normal values in children age 6 through to 17 years Eur Respir J 200526 453 45710.1183/09031936.05.0001520516135727Search in Google Scholar

58Karadag B, James AJ, Gultekin E, Wilson NM, Bush A. Nasal and lower airway level of nitric oxide in children with primary ciliary dyskinesia. Eur Respir J. 1999;13:1402-1405.Karadag B James AJ Gultekin E Wilson NM Bush A Nasal and lower airway level of nitric oxide in children with primary ciliary dyskinesia Eur Respir J 1999131402 140510.1183/09031936.99.1361406910445619Search in Google Scholar

59Narang I, Ersu R, Wilson NM, Bush A. Nitric oxide in chronic airway inflammation in children: diagnostic use and pathophysiological significance. Thorax 2002;57: 586-589.Narang I Ersu R Wilson NM Bush A Nitric oxide in chronic airway inflammation in children: diagnostic use and pathophysiological significance Thorax 200257 586 58910.1136/thorax.57.7.586174636912096200Search in Google Scholar

60Krzych-Fałta E, Sybilski A, Samoliński B, Wojas O.. Jeden układ – dwa pomiary stężenia tlenku azotu w donosowej próbie prowokacyjnej z alergenem. Alergia Astma Immunologia 2015;20:111-116.Krzych-Fałta E Sybilski A Samoliński B Wojas O. Jeden układ – dwa pomiary stężenia tlenku azotu w donosowej próbie prowokacyjnej z alergenem Alergia Astma Immunologia 201520111 116Search in Google Scholar

61Wang Pp, Wang Gx, Ge Wt, Tang LX, Zhang J, Ni X. Nasal nitric oxide in allergic rhinitis in children and its relationship to severity and treatment. Allergy Asthma Clin Immunol. 2017;13:20.Wang Pp Wang Gx Ge Wt Tang LX Zhang J Ni X Nasal nitric oxide in allergic rhinitis in children and its relationship to severity and treatment Allergy Asthma Clin Immunol 2017132010.1186/s13223-017-0191-z538113628396691Search in Google Scholar