<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Placental pathology is associated with major pregnancy disorders and the concept of the Great Placental Syndromes encompasses disorders of placentation, such as preeclampsia with and without fetal growth restriction, preterm labor, preterm premature rupture of membranes, late spontaneous abortion, and placental abruption. Preeclampsia is divided between the early and late onset variety and placental dysfunction is a central feature in the pathogenesis of both. In the early onset type, syncytiotrophoblastic stress seems to be related to an inherent defect of the trophoblast. Vascular protection of early placental development is replaced by vascular dysfunction. In late onset preeclampsia, maternal factors, such as genotypic predisposition to endothelial disease, and an impairment of antioxidant defence with a limited capacity of the maternal clearing system to cope with the increasing charge of apoptotic cell debris, are at the center of pathogenesis. Syncytiotrophoblastic stress in late pregnancy has been related to molecular senescence and late onset preeclampsia may be viewed as an exaggeration of normal placental ageing.</p></abstract>

Placental pathology is associated with major pregnancy disorders and the concept of the Great Placental Syndromes encompasses disorders of placentation, such as preeclampsia with and without fetal growth restriction, preterm labor, preterm premature rupture of membranes, late spontaneous abortion, and placental abruption. Preeclampsia is divided between the early and late onset variety and placental dysfunction is a central feature in the pathogenesis of both. In the early onset type, syncytiotrophoblastic stress seems to be related to an inherent defect of the trophoblast. Vascular protection of early placental development is replaced by vascular dysfunction. In late onset preeclampsia, maternal factors, such as genotypic predisposition to endothelial disease, and an impairment of antioxidant defence with a limited capacity of the maternal clearing system to cope with the increasing charge of apoptotic cell debris, are at the center of pathogenesis. Syncytiotrophoblastic stress in late pregnancy has been related to molecular senescence and late onset preeclampsia may be viewed as an exaggeration of normal placental ageing.

Placental dysfunction as a key element in the pathogenesis of preeclampsia

Journal of Mother and Child

This work is licensed under the Creative Commons Attribution 4.0 International License.

{"article-title":"Placental dysfunction as a key element in the pathogenesis of preeclampsia"}

Placental pathology is associated with major pregnancy disorders and the concept of the Great Placental Syndromes encompasses disorders of placentation, such...

Placental dysfunction as a key element in the pathogenesis of preeclampsia

Article Category: Special contribution

Published Online: Jan 02, 2018

Page range: 309 - 316

Received: Aug 30, 2017

Accepted: Sep 06, 2017

DOI: https://doi.org/10.34763/devperiodmed.20172104.309316

Keywords
preeclampsia, early placental development - vascular protection, early placental development - vascular dysfunction, syncytiotrophoblastic stress, antioxidant defence, predisposition to endothelial disease

© 2017 Henning Schneider, published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Placental dysfunction as a key element in the pathogenesis of preeclampsia

Article Category: Special contribution

Published Online: Jan 02, 2018

Page range: 309 - 316

Received: Aug 30, 2017

Accepted: Sep 06, 2017

DOI: https://doi.org/10.34763/devperiodmed.20172104.309316

Keywordspreeclampsia, early placental development - vascular protection, early placental development - vascular dysfunction, syncytiotrophoblastic stress, antioxidant defence, predisposition to endothelial disease

© 2017 Henning Schneider, published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
preeclampsia, early placental development - vascular protection, early placental development - vascular dysfunction, syncytiotrophoblastic stress, antioxidant defence, predisposition to endothelial disease