<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Sixty-five colistin-resistant Enterobacterales isolates recovered from different clinical specimens were analyzed. The strains were collected in 12 hospitals all over Poland within a period of nine months. Strains were analyzed for eight genes from the <italic>mcr</italic> family. The presence of <italic>mcr</italic>-1 gene was detected in three <italic>Escherichia coli</italic> strains. The 45/65 isolates were identified as ESBL producers. CTX-M-1-like enzymes were the most common ESBLs (n = 40). One <italic>E. coli</italic> and seven <italic>Klebsiella pneumoniae</italic> strains produced carbapenemases, with the NDM being produced by five isolates. Among all the strains tested, four and five were resistant to new drugs meropenem/vaborbactam and ceftazidime/avibactam, respectively.</p></abstract>

Sixty-five colistin-resistant Enterobacterales isolates recovered from different clinical specimens were analyzed. The strains were collected in 12 hospitals all over Poland within a period of nine months. Strains were analyzed for eight genes from the mcr family. The presence of mcr-1 gene was detected in three Escherichia coli strains. The 45/65 isolates were identified as ESBL producers. CTX-M-1-like enzymes were the most common ESBLs (n = 40). One E. coli and seven Klebsiella pneumoniae strains produced carbapenemases, with the NDM being produced by five isolates. Among all the strains tested, four and five were resistant to new drugs meropenem/vaborbactam and ceftazidime/avibactam, respectively.

Occurrence of Beta-Lactamases in Colistin-Resistant Enterobacterales Strains in Poland – a Pilot Study

Polish Journal of Microbiology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Sixty-five colistin-resistant Enterobacterales isolates recovered from different clinical specimens were analyzed. The strains were collected in 12 hospitals...

Occurrence of Beta-Lactamases in Colistin-Resistant Enterobacterales Strains in Poland – a Pilot Study

Article Category: short-communication

Published Online: Dec 06, 2021

Page range: 283 - 288

Received: Feb 19, 2021

Accepted: May 10, 2021

DOI: https://doi.org/10.33073/pjm-2021-021

Keywords
Enterobacterales, colistin-resistance, ESBLs, carbapenemases

© 2021 Elżbieta M. Stefaniuk et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Occurrence of Beta-Lactamases in Colistin-Resistant Enterobacterales Strains in Poland – a Pilot Study

Article Category: short-communication

Published Online: Dec 06, 2021

Page range: 283 - 288

Received: Feb 19, 2021

Accepted: May 10, 2021

DOI: https://doi.org/10.33073/pjm-2021-021

KeywordsEnterobacterales, colistin-resistance, ESBLs, carbapenemases

© 2021 Elżbieta M. Stefaniuk et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
Enterobacterales, colistin-resistance, ESBLs, carbapenemases