<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Among the species belonging to the <italic>Aspergillus</italic> section <italic>Versicolores</italic>, <italic>Aspergillus creber</italic> has been poorly studied and still unexplored for its biological activities. The present study was undertaken to analyze <italic>A. creber</italic> extract and to evaluate its <italic>in vitro</italic> antimicrobial and anti-oxidant activities. UHPLC-MS/MS analysis of <italic>A. creber</italic> extract allowed the characterization of five known fungal metabolites including: asperlactone, emodin, sterigmatocystin, deoxybrevianamide E, and norsolorinic acid. The highest antimicrobial activity was displayed against <italic>Candida albicans</italic>, with a mean strongest inhibition zone of 20.6 ± 0.8 mm, followed by Gram-positive drug-resistant bacteria. The MIC values of <italic>A. creber</italic> extract varied from 0.325 mg/ml to 5 mg/ml. <italic>A. creber</italic> extract was shown a potent antioxidant activity and a high level of phenolic compounds by recording 89.28% scavenging effect for DPPH free radical, 92.93% in ABTS assay, and 85.76 mg gallic acid equivalents/g extract in Folin-Ciocalteu assay. To our knowledge, this is the first study concerning biological and chemical activities of <italic>A. creber</italic> species<italic>.</italic> Based on the obtained results, <italic>A. creber</italic> could be a promising source of natural antimicrobial and antioxidant compounds.</p></abstract>

Among the species belonging to the Aspergillus section Versicolores, Aspergillus creber has been poorly studied and still unexplored for its biological activities. The present study was undertaken to analyze A. creber extract and to evaluate its in vitro antimicrobial and anti-oxidant activities. UHPLC-MS/MS analysis of A. creber extract allowed the characterization of five known fungal metabolites including: asperlactone, emodin, sterigmatocystin, deoxybrevianamide E, and norsolorinic acid. The highest antimicrobial activity was displayed against Candida albicans, with a mean strongest inhibition zone of 20.6 ± 0.8 mm, followed by Gram-positive drug-resistant bacteria. The MIC values of A. creber extract varied from 0.325 mg/ml to 5 mg/ml. A. creber extract was shown a potent antioxidant activity and a high level of phenolic compounds by recording 89.28% scavenging effect for DPPH free radical, 92.93% in ABTS assay, and 85.76 mg gallic acid equivalents/g extract in Folin-Ciocalteu assay. To our knowledge, this is the first study concerning biological and chemical activities of A. creber species. Based on the obtained results, A. creber could be a promising source of natural antimicrobial and antioxidant compounds.

Chemical Composition of <italic>Aspergillus creber</italic> Extract and Evaluation of its Antimicrobial and Antioxidant Activities

Polish Journal of Microbiology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Chemical Composition of  Extract and Evaluation of its Antimicrobial and Antioxidant Activities

Among the species belonging to the Aspergillus section Versicolores, Aspergillus creber has been poorly studied and still unexplored for its biological...

Chemical Composition of Aspergillus creber Extract and Evaluation of its Antimicrobial and Antioxidant Activities

Article Category: original-paper

Published Online: Sep 03, 2019

Page range: 309 - 316

Received: Mar 18, 2019

Accepted: May 07, 2019

DOI: https://doi.org/10.33073/pjm-2019-033

Keywords
Antimicrobial activity, antioxidant activity, UHPLC-MS/MS,

© 2019 Anton Pyskun et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Chemical Composition of Aspergillus creber Extract and Evaluation of its Antimicrobial and Antioxidant Activities

Article Category: original-paper

Published Online: Sep 03, 2019

Page range: 309 - 316

Received: Mar 18, 2019

Accepted: May 07, 2019

DOI: https://doi.org/10.33073/pjm-2019-033

KeywordsAntimicrobial activity, antioxidant activity, UHPLC-MS/MS,

© 2019 Anton Pyskun et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
Antimicrobial activity, antioxidant activity, UHPLC-MS/MS,