1. bookVolume 1 (2009): Issue 3 (September 2009)
Journal Details
License
Format
Journal
eISSN
2406-0631
ISSN
1821-0902
First Published
12 Feb 2012
Publication timeframe
4 times per year
Languages
English
access type Open Access

Treatment of venous leg ulcers with an ointment containing yarrow (Achillea millefolium) extract / Primena preparata sa ekstraktom hajdučke trave (Achillea millefolium) u lečenju venskih ulkusa potkolenice

Journal Details
License
Format
Journal
eISSN
2406-0631
ISSN
1821-0902
First Published
12 Feb 2012
Publication timeframe
4 times per year
Languages
English
Abstract

Traditional medicine credits yarrow (Achillea millefolium) with the ability to accelerate wound healing. The purpose of this research was to determine the effects of yarrow on the epithelization of the lower leg venous ulcers. The study included 39 patients with venous leg ulcers. They were divided into two groups: the first (experimental) group of patients were treated with an ointment containing 7.5% of yarrow extract. In the second (control) group, saline solution dressings were applied to ulcers, within the period of three weeks. In the experimental group, at the beginning of the therapy, the total surface of all the ulcers was 44736 mm2. After three weeks, the total surface of all the ulcers was 27000 mm2 (a decrease of 39.64%). In the control group, at the beginning of the therapy, the total surface of all the ulcers was 46116 mm2. At the end of the study (21 days) the total surface of all the ulcers was 39153 mm2 (a decrease of 15.1%). Herbal preparations are suitable for application in the therapy of venous ulcers, but their efficiency in wound healing is still to be investigated.

1. Beebe-Dimmer JL, Pfeifer JR, Engle JS, Schottenfeld D. The epidemiology of chronic venous insufficiency and varicose veins. Ann Epidemiol 2005;15(3):175-84.10.1016/j.annepidem.2004.05.015Search in Google Scholar

2. Fowkes FG, Evans CJ, Lee AJ. Prevalence and risk factors of chronic venous insufficiency. Angiology 2001;52(Suppl 1):S5-15.10.1177/0003319701052001S02Search in Google Scholar

3. Browse NL, Burnard KG, Thomas ML. Diseases of the veins: pathology, diagnosis and treatment. Baltimore: Edward Arnold; 1988:445-6.Search in Google Scholar

4. Baker SR, Stacey MC, Jopp-McKay AG, Hoskin SE, Thompson PJ. Epidemiology of chronic venous ulcers. Br J Surg 1991;78(7):864-710.1002/bjs.1800780729Search in Google Scholar

5. Lopez AP, Phillips TJ. Venous ulcers. Wounds 1998;10:149-57.Search in Google Scholar

6. Bruneton J. Pharmacognosy: phytochemistry of medicinal plants. Paris: Lavoisie Publishing; 1995:337-9.Search in Google Scholar

7. Barbour EK, Sharif MA, Sagherian VK, Habre AN, Talhouk RS, Talhouk SN. Screening of selected indigenous plants of Lebanon for antimicrobial activity. J Ethnopharmacol 2004;93:1-7.10.1016/j.jep.2004.02.027Search in Google Scholar

8. Candan F, Unlu M, Tepe B, Daferera D, Polissiou M, Sokmen A, et al. Antioxidant and antimicrobial activity of the essential oil and methanol extracts of Achillea millefolium subsp. millefolium Afan. (Asteraceae). J Ethnopharmacol 2003;87:215-20.10.1016/S0378-8741(03)00149-1Search in Google Scholar

9. Stojanović G, Radulović N, Hashimoto T, Palić R. In vitro antimicrobial activity of extracts of four Achillea species: the composition of Achillea clavennae L. (Asteraceae) extract. J Ethnopharmacol 2005;101:185-90.10.1016/j.jep.2005.04.02615978758Search in Google Scholar

10. Gale T. Yarrow: encyclopedia of alternative medicine, 2006. eNotes.com. 2006. 26 Jan, 2007. Available from: http://health.enotes.com/alternative-medicine-encyclopedia/yarrowSearch in Google Scholar

11. Bisset NG, Wichtl M, eds. Herbal drugs and phytopharmaceuticals. Boca Raton: CRC Press; 2001:342-4.Search in Google Scholar

12. Blumenthal R. The complete German commission E monographs. Austin: American Botanical Council; 1999:233-4.Search in Google Scholar

13. Wichtl M. Herbal drugs and phytopharmaceuticals. Boca Raton: CRC Press; 1994:342-7.Search in Google Scholar

14. Paulsen E. Contact sensitization from Compositaecontaining herbal remedies and cosmetics. Contact Dermatitis 2002;47:189-98.10.1034/j.1600-0536.2002.470401.x12492516Search in Google Scholar

15. Lachapelle JM, Maibach HI. Methodology of patch testing. In: Lachapelle JM, Maibach HI, eds. Patch testing Prick testing: a practical guide (official publication of ICDRG). Berlin: Springer; 2003:27-49.10.1007/978-3-662-09215-6_3Search in Google Scholar

16. Đuran V, Matić M, Jovanović M, Mimica N, Gajinov Z, Poljački M, et al. Results of the clinical examination of an ointment with the marigold (Calendula officinalis) extract in the treatment of venous leg ulcers. Int J Tissue React 2005;27(3):101-6.Search in Google Scholar

17. Đuran V, Matić M, Zrnić B, Poljački M, Jovanović M, Dimoski A. Rezultati kliničkog ispitivanja Plantoderm masti u bolesnika sa venskim ulceracijama donjih ekstremiteta. Arh Farm 1997;5:526-7.Search in Google Scholar

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