<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>(<italic>S</italic>)-<italic>N</italic>-(2-(4,5-dihydro-3<italic>H</italic>-dinaphtho[2,1-c:1',2'-e]azepin-1-yl)ethyl)-<italic>N, N</italic>-dimethyl-<italic>N</italic>-dodecyl ammonium bromide (<bold><italic>S</italic>)-1a</bold> and (<italic>S</italic>)-<italic>N</italic>-(2-(4,5-dihydro-3<italic>H</italic>-dinaphtho[2,1-c:1',2'-e]azepin-1-yl)ethyl)-<italic>N, N</italic>-dimethyl-<italic>N</italic>-tetradecylammonium bromide <bold>(<italic>S</italic>)-1b</bold> have been synthesized as optically active quaternary ammonium salts starting from 1,1'-binaphthyl-2,2'-diol. Their antimicrobial activity expressed as minimal inhibition concentration (MIC) was tested against Gram-positive human pathogenic bacteria <italic>S. Aureus</italic>, Gram-negative bacteria <italic>E. coli</italic> and human fungal pathogen <italic>C. Albicans</italic>.</p></abstract>

(S)-N-(2-(4,5-dihydro-3H-dinaphtho[2,1-c:1',2'-e]azepin-1-yl)ethyl)-N, N-dimethyl-N-dodecyl ammonium bromide (S)-1a and (S)-N-(2-(4,5-dihydro-3H-dinaphtho[2,1-c:1',2'-e]azepin-1-yl)ethyl)-N, N-dimethyl-N-tetradecylammonium bromide (S)-1b have been synthesized as optically active quaternary ammonium salts starting from 1,1'-binaphthyl-2,2'-diol. Their antimicrobial activity expressed as minimal inhibition concentration (MIC) was tested against Gram-positive human pathogenic bacteria S. Aureus, Gram-negative bacteria E. coli and human fungal pathogen C. Albicans.

Synthesis and antimicrobial properties of binaphthyl derived quaternary ammonium bromides

Faculty of Pharmacy, Department of Chemical Theory of Drugs, Comenius University in Bratislava

Faculty of Pharmacy, Department of Cell and Molecular Biology of Drugs, Comenius University in Bratislava

European Pharmaceutical Journal

(S)-N-(2-(4,5-dihydro-3H-dinaphtho[2,1-c:1',2'-e]azepin-1-yl)ethyl)-N, N-dimethyl-N-dodecyl ammonium bromide (S)-1a and...

Synthesis and antimicrobial properties of binaphthyl derived quaternary ammonium bromides

Published Online: Aug 13, 2012

Page range: 39 - 47

DOI: https://doi.org/10.2478/v10219-012-0017-5

Keywords
quaternary ammonium bromides, antimicrobial activity, binaphthyl

This content is open access.

Synthesis and antimicrobial properties of binaphthyl derived quaternary ammonium bromides

Published Online: Aug 13, 2012

Page range: 39 - 47

DOI: https://doi.org/10.2478/v10219-012-0017-5

Keywordsquaternary ammonium bromides, antimicrobial activity, binaphthyl

This content is open access.

Keywords
quaternary ammonium bromides, antimicrobial activity, binaphthyl