<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Propranolol is one of the first prepared and in therapeutic praxis used beta- adrenolytics. In this paper novel derivatives of propranolol with cyclohexylamino and pyrrolidin-1-yl groups in hydrophilic part were prepared. HPLC-enantioseparation propranolol (as reference compound) and of the prepared derivatives has been achieved using a Chiralpak AD CSP based on the amylose tris (3,5-dimethylphenylcarbamate).(<italic>R</italic>)-enantiomer of the propranolol was prepared by stereoselective synthesis using Jacobsen catalyst.</p></abstract>

Propranolol is one of the first prepared and in therapeutic praxis used beta- adrenolytics. In this paper novel derivatives of propranolol with cyclohexylamino and pyrrolidin-1-yl groups in hydrophilic part were prepared. HPLC-enantioseparation propranolol (as reference compound) and of the prepared derivatives has been achieved using a Chiralpak AD CSP based on the amylose tris (3,5-dimethylphenylcarbamate).(R)-enantiomer of the propranolol was prepared by stereoselective synthesis using Jacobsen catalyst.

Synthesis and enantioseparation of derivatives of propranolol

Faculty of Pharmacy, Department of Chemical Theory of Drugs, Comenius University in Bratislava

European Pharmaceutical Journal

{"article-title":"Synthesis and enantioseparation of derivatives of propranolol"}

Propranolol is one of the first prepared and in therapeutic praxis used beta- adrenolytics. In this paper novel derivatives of propranolol with cyclohexylamino...

Synthesis and enantioseparation of derivatives of propranolol

Published Online: Aug 13, 2012

Page range: 5 - 13

DOI: https://doi.org/10.2478/v10219-012-0012-x

Keywords
propranolol, β-blockers, enantioseparation, HPLC, Chiralpak AD CSP

This content is open access.

Synthesis and enantioseparation of derivatives of propranolol

Published Online: Aug 13, 2012

Page range: 5 - 13

DOI: https://doi.org/10.2478/v10219-012-0012-x

Keywordspropranolol, β-blockers, enantioseparation, HPLC, Chiralpak AD CSP

This content is open access.

Keywords
propranolol, β-blockers, enantioseparation, HPLC, Chiralpak AD CSP