<abstract xmlns="http://www.w3.org/1999/xhtml"><p> One of the aims of the meta-analysis of clinical trials is to deter- mine the efficacy of a new type of treatment. This efficacy is commonly measured by the difference between the efficacy of a standard treatment and the new treatment. For binary data the difference can be measured by a probability difference. We investigate, by simulations and using box plots, the basic statistical properties of the point estimator of the probability difference of overall treatment effects in the meta-analysis based on multicentre trials for various chosen situations. This estimator was suggested in Dokoupilova (2011).</p></abstract>

One of the aims of the meta-analysis of clinical trials is to deter- mine the efficacy of a new type of treatment. This efficacy is commonly measured by the difference between the efficacy of a standard treatment and the new treatment. For binary data the difference can be measured by a probability difference. We investigate, by simulations and using box plots, the basic statistical properties of the point estimator of the probability difference of overall treatment effects in the meta-analysis based on multicentre trials for various chosen situations. This estimator was suggested in Dokoupilova (2011).

A point estimator of the probability difference of overall treatment effect–simulation study

Department of Mathematics and Statistics, Faculty of Science, Masaryk University, Kotlářská 2, CZ–611-37 Brno, CZECH REPUBLIC

Tatra Mountains Mathematical Publications

One of the aims of the meta-analysis of clinical trials is to deter- mine the efficacy of a new type of treatment. This efficacy is commonly measured by the...

A point estimator of the probability difference of overall treatment effect–simulation study

Published Online: Nov 13, 2012

Page range: 25 - 38

DOI: https://doi.org/10.2478/v10127-011-0034-0

Keywords
multicenter trial, point estimator, probability of success, probability difference, linear model with random effects.

This content is open access.

A point estimator of the probability difference of overall treatment effect–simulation study

Published Online: Nov 13, 2012

Page range: 25 - 38

DOI: https://doi.org/10.2478/v10127-011-0034-0

Keywordsmulticenter trial, point estimator, probability of success, probability difference, linear model with random effects.

This content is open access.

Keywords
multicenter trial, point estimator, probability of success, probability difference, linear model with random effects.