<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><italic>Study aim:</italic> To evaluate plasma homocysteine (Hcy), insulin and glucose levels in blood and the insulin resistance index (FIRI) in young, healthy non-obese men and women.<italic>Material and methods:</italic> A total of 152 young, healthy, non-obese (BMI&lt;30) men (n = 81) and women (n = 71) participated in the study. The following substances were assayed in blood using commercial kits: total plasma homocysteine by fluorescence polarisation immunoassay, plasma glucose - by the oxidase method, and insulin by radioimmunoassay using monoclonal antibodies. From the latter two, the index of insulin resistance (FIRI) was computed.<italic>Results:</italic> Mean plasma homocysteine concentration in men was significantly (p&lt;0.001) higher than in women (10.3 ± 3.0 and 8.4 ± 2.4 μmol/l, respectively) and that of FIRI was significantly (p&lt;0.001) lower than in women (1.310 ± 0.483 and 1.437 ± 0.420, respectively). Neither in men nor in women were plasma homocysteine concentrations correlated with FIRI.<italic>Conclusions:</italic> Although no association between circulating homocysteine and FIRI was found in young, non-obese men and women, the existence of such association in Type 2 diabetes cannot be ruled out.</abstract>

Study aim: To evaluate plasma homocysteine (Hcy), insulin and glucose levels in blood and the insulin resistance index (FIRI) in young, healthy non-obese men and women.Material and methods: A total of 152 young, healthy, non-obese (BMI<30) men (n = 81) and women (n = 71) participated in the study. The following substances were assayed in blood using commercial kits: total plasma homocysteine by fluorescence polarisation immunoassay, plasma glucose - by the oxidase method, and insulin by radioimmunoassay using monoclonal antibodies. From the latter two, the index of insulin resistance (FIRI) was computed.Results: Mean plasma homocysteine concentration in men was significantly (p<0.001) higher than in women (10.3 ± 3.0 and 8.4 ± 2.4 μmol/l, respectively) and that of FIRI was significantly (p<0.001) lower than in women (1.310 ± 0.483 and 1.437 ± 0.420, respectively). Neither in men nor in women were plasma homocysteine concentrations correlated with FIRI.Conclusions: Although no association between circulating homocysteine and FIRI was found in young, non-obese men and women, the existence of such association in Type 2 diabetes cannot be ruled out.

The index of insulin resistance (FIRI) is not associated with plasma homocysteine levels in young, non-obese healthy men and women

Department of Physiology, University of Physical Education, Warsaw, Poland

Department of Biochemistry, University of Physical Education, Warsaw, Poland

Department of Sports Medicine, University of Physical Education, Warsaw, Poland

Department of Newborn Screening, Institute of Mother and Child, Warsaw, Poland

Department of Physiology, Institute of Sport, Warsaw, Poland

Biomedical Human Kinetics

Study aim: To evaluate plasma homocysteine (Hcy), insulin and glucose levels in blood and the insulin resistance index (FIRI) in young, healthy non-obese men...

The index of insulin resistance (FIRI) is not associated with plasma homocysteine levels in young, non-obese healthy men and women

Published Online: Mar 03, 2011

Page range: 14 - 17

DOI: https://doi.org/10.2478/v10101-011-0004-7

Keywords
Homocysteine, Insulin resistance index, Non-obese subjects

This content is open access.

The index of insulin resistance (FIRI) is not associated with plasma homocysteine levels in young, non-obese healthy men and women

Published Online: Mar 03, 2011

Page range: 14 - 17

DOI: https://doi.org/10.2478/v10101-011-0004-7

KeywordsHomocysteine, Insulin resistance index, Non-obese subjects

This content is open access.

Keywords
Homocysteine, Insulin resistance index, Non-obese subjects