<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Experiments to assess the effectiveness of the immunostimulator methisoprinol (Polfa Grodzisk Pharmaceuticals, Poland) focused on its impact on the innate immune response. The impact of different doses of methisoprinol on organ leukocytes isolated from the kidneys and spleens of African catfish that were subjected to or not subjected to the suppressive impact of iridovirus. The results indicate that the addition of methisoprinol causes increased respiratory burst activity (RBA), potential killing activity (PKA), and proliferative activity of lymphocytes T and B in response to mitogens. Methisoprinol stimulates the mechanisms of cellular immunity that are linked to the activation of T lymphocytes, which can impact the antiviral activity of this preparation after its application <italic>in vivo.</italic></p></abstract>

Experiments to assess the effectiveness of the immunostimulator methisoprinol (Polfa Grodzisk Pharmaceuticals, Poland) focused on its impact on the innate immune response. The impact of different doses of methisoprinol on organ leukocytes isolated from the kidneys and spleens of African catfish that were subjected to or not subjected to the suppressive impact of iridovirus. The results indicate that the addition of methisoprinol causes increased respiratory burst activity (RBA), potential killing activity (PKA), and proliferative activity of lymphocytes T and B in response to mitogens. Methisoprinol stimulates the mechanisms of cellular immunity that are linked to the activation of T lymphocytes, which can impact the antiviral activity of this preparation after its application in vivo.

Impact of iridovirus and methisoprinol on immunocompetent cells isolated from African catfish, <italic>Clarias gariepinus</italic> (Burchell), under <italic>in vitro</italic> conditions

Department of Fish Pathology and Immunology, Żabieniec Inland Fisheries Institute in Olsztyn, Główna 48, 05-500 Żabieniec, Poland

Fisheries & Aquatic Life

Impact of iridovirus and methisoprinol on immunocompetent cells isolated from African catfish,  (Burchell), under  conditions

Experiments to assess the effectiveness of the immunostimulator methisoprinol (Polfa Grodzisk Pharmaceuticals, Poland) focused on its impact on the innate...

Impact of iridovirus and methisoprinol on immunocompetent cells isolated from African catfish, Clarias gariepinus (Burchell), under in vitro conditions

Published Online: Apr 25, 2011

Page range: 31 - 36

DOI: https://doi.org/10.2478/v10086-011-0004-9

Keywords
methisoprinol, immunostimulation, African catfish

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