<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Multidrug resistance is the main problem in anticancer therapy. Cancer cells use many defense strategies in order to survive chemotherapy. Among known multidrug resistance mechanisms the most important are: drug detoxification inside the cell using II phase detoxifying enzymes and active transport of the drug to the extracellular environment. Cancer cells may be also less sensitive to proapoptotic signals and have different intracellular drug distribution, which makes them more resistant to anticancer drugs. Role of glutathione in multidrug resistance is the object of interest of many scientists, however, defining it’s function in these processes still remains a challenge. In this paper, properties of glutathione and it’s role in multidrug resistance in cancer cells were described.</p></abstract>

Multidrug resistance is the main problem in anticancer therapy. Cancer cells use many defense strategies in order to survive chemotherapy. Among known multidrug resistance mechanisms the most important are: drug detoxification inside the cell using II phase detoxifying enzymes and active transport of the drug to the extracellular environment. Cancer cells may be also less sensitive to proapoptotic signals and have different intracellular drug distribution, which makes them more resistant to anticancer drugs. Role of glutathione in multidrug resistance is the object of interest of many scientists, however, defining it’s function in these processes still remains a challenge. In this paper, properties of glutathione and it’s role in multidrug resistance in cancer cells were described.

Role of Glutathione in the Multidrug Resistance in Cancer

Biochemistry and Biopharmaceuticals Department, National Medicines Institute, 30/34 Chelmska Street, 00-725 Warsaw

Medical Journal of Cell Biology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Role of Glutathione in the Multidrug Resistance in Cancer"}

Multidrug resistance is the main problem in anticancer therapy. Cancer cells use many defense strategies in order to survive chemotherapy. Among known...

Role of Glutathione in the Multidrug Resistance in Cancer

Published Online: Oct 15, 2014

Page range: 105 - 124

DOI: https://doi.org/10.2478/v10052-010-0006-6

Keywords
glutathione, glutathione-dependent enzymes, transport, MRP, MDR, multidrug resistance, cancer, drug resistance

© by Ewa Karwicka

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Role of Glutathione in the Multidrug Resistance in Cancer

Published Online: Oct 15, 2014

Page range: 105 - 124

DOI: https://doi.org/10.2478/v10052-010-0006-6

Keywordsglutathione, glutathione-dependent enzymes, transport, MRP, MDR, multidrug resistance, cancer, drug resistance

© by Ewa Karwicka

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
glutathione, glutathione-dependent enzymes, transport, MRP, MDR, multidrug resistance, cancer, drug resistance