<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>The transition from a normal to a neoplastic cell is a complex process and involves many sequential genetic events. Over the last several years, substantial progress has been made in the understanding of molecular biology of melanoma including its development, progression, and resistance to therapy. An important step in cancer development appears to be senescence — a crucial barrier that prevents the proliferation of cells that are at different stages of malignancy. This review is mainly focused on patterns of molecular changes in the different steps of neoplastic transformation in melanoma and provides an up-to-date view on our understanding of the molecular genetics of melanoma development as well as therapeutic approaches based on this knowledge.</p></abstract>

The transition from a normal to a neoplastic cell is a complex process and involves many sequential genetic events. Over the last several years, substantial progress has been made in the understanding of molecular biology of melanoma including its development, progression, and resistance to therapy. An important step in cancer development appears to be senescence — a crucial barrier that prevents the proliferation of cells that are at different stages of malignancy. This review is mainly focused on patterns of molecular changes in the different steps of neoplastic transformation in melanoma and provides an up-to-date view on our understanding of the molecular genetics of melanoma development as well as therapeutic approaches based on this knowledge.

Genetic alteration in melanoma development

Latvian Biomedical Research and Study Centre, Rātsupítes iela 1, Rīga, LV-1067, LATVIA

Rīga Stradiņš University, Dzirciema iela 16, Rīga, LV-1017, LATVIA

Department of Oral Pathology, Rīga Stradiņš University, Dzirciema iela 16, Rīga, LV-1007, LATVIA

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

{"article-title":"Genetic alteration in melanoma development"}

The transition from a normal to a neoplastic cell is a complex process and involves many sequential genetic events. Over the last several years, substantial...

Genetic alteration in melanoma development

Published Online: Nov 06, 2009

Page range: 73 - 80

DOI: https://doi.org/10.2478/v10046-009-0029-2

Keywords
cancer, melanoma, genes, mutations, genetics

This content is open access.

Genetic alteration in melanoma development

Published Online: Nov 06, 2009

Page range: 73 - 80

DOI: https://doi.org/10.2478/v10046-009-0029-2

Keywordscancer, melanoma, genes, mutations, genetics

This content is open access.

Keywords
cancer, melanoma, genes, mutations, genetics